One hundred and eight cases of pulmonary abscess have been treated with intratracheal injection of penicillin, terramycin and kanamycin. The injections were given by crico-thyroid route every day or every the other day for several months. Seventy-six cases were cured and twenty-three improved.
This route of injection is easy and safe in everyday performance, and convenient in getting tracheal sputum for bacteriological examination to select the best suitable antibiotics.
In this paper the effectiveness of this method was confirmed in comparing the concentration of these three antibiotics with that in systemic administration.
The concentration of antibiotics in the sputum of the patients and in the lobe of rabbits lung injected intratracheally was about 1, 000 times higher and sustained longer than that given intramusculary or intravenously.
The antibiotics injected intratracheally into rabbits lung stayed longer, for more than 24 hours, and in higher concentration at the desired lobe than the other lobes.
The concentration of antibiotics in the serum injected intratracheally was lower in the patients with larger amount of sputum than with smaller one. In the latter and in rabbits it was about the same with that given intramuscularly or intravenously.
The highest lebel of serum antibiotics concentration was obtained later in intratracheal than intravenous or intramuscular administration.
In patients with large amount of sputum, urine excretion of antibiotics injected intratracheally was smaller than in those with small amount of sputum. In the latter and in rabbits the urine excretion of antibiotics was about the same with either of intratracheal, intramuscular or intravenous injection.
In intratracheal, intramuscular and intravenous injection of these three antibiotics, the concentration of penicillin increased and decreased faster than those of the other two in sputum, lung, serum and urine.
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