We investigated the effects of repeated sevoflurane anesthesia on hepatic and renal function prospectively. In 27 patients (ASA I-II) for 80 repeated sevoflurane anesthesia cases, AST (GOT) and ALT (GPT) were measured as indicators of hepatic function, and blood urea nitrogen (BUN) and serum creatinine (Cre) were measured as indicators of renal function just before the operation and 1, 3, 7, 14, and 21 days after the operation. There were 11 anesthesia cases with abnormal AST or ALT values, and 5 anesthesia cases with BUN or Cre abnormalities. These abnormal changes in laboratory findings, however, were transient and slight, and there was no relationship between these abnormal changes and the use of sevoflurane. Moreover, there was no relationship between the cases which showed abnormal values and the number of times sevoflurane anesthesia was repeated. Two patients who had had slight hepatic and/or renal dysfunction preoperatively did not show any exacerbation of these organ dysfunctions after repeated sevoflurane anesthesia. The authors conclude that sevoflurane is a safe inhalation anesthetic for repeated use.
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