We investigated the effect of lumbar epidural anesthesia on the hepatic blood flow during sevoflurane or propofol anesthesia by detecting the indocyanine green clearance rate (KICG). Thirty-two patients (n=8 in each group) scheduled for arthroscopic knee surgery were chosen and they received anesthesia consisting of 1) N
2O-O
2-1.7% sevoflurane (S-group), 2) N
2O-O
2-1.7% sevoflurane with an intravenous administration of 0.05 μg•kg
-1 •min
-1 of prostaglandin E
1 (SP-group), 3) N
2O-O
2-1.0% sevoflurane and lumbar epidural anesthesia with an infusion rate of 0.1ml•kg
-1•h
-1 of 1.5% lidocaine (SE-group), and 4) N
2O-O
2-5mg•kg
-1•h
-1 of propofol (PE-group) with the same rate of epidural lidocaine as the SE-group. KICG and cardiac output (CO) were measured before and during anesthesia. The results were as follows: 1) KICG decreased in the SE-and PE-groups; 2) CO also decreased in both groups; 3) in the SP-group, KICG and CO were significantly higher than those in the SE- and PE-groups. The present study indicates that lumbar epidural anesthesia combined with general anesthesia seriously, depresses CO and estimated hepatic blood flow whereas administration of PGE
1 during anesthesia could produce a protective effect on hepatic circulation by maintaining CO.
View full abstract