Ephedrine and adrenaline are key drugs that are indispensable for acute phase patient management. In the history of medicine and pharmaceuticals, Nagayoshi Nagai and Jokichi Takamine are commonly credited as having developed these drugs. However, Keizo Uenaka was the key scientist who worked on ephedrine and played a direct role in the purification and crystallization of adrenaline. After repeating his experiment from 111 years ago, I realized first-hand that Uenaka's technique was highly sophisticated, as he took special care to prevent the oxidization of adrenaline throughout the purification process.
Although Uenaka was the main scientist and technician in adrenaline purification, his name is almost never referred to in scientific meetings nor documented explicitly in publications. This might be explained by the fact that Takamine was more focused on industrial applications than pure science.
Only recently has Uenaka's contribution been brought to light. Historical research by Aiko Yamashita and Sosogu Nakayama uncovered Uenaka's handwritten memorandum, “On adrenalin, Memorandum, July to December, 1900”. This historically important evidence of adrenaline purification by Uenaka and Takamine, has been registered as Japanese cultural heritage by The Chemical Society of Japan and The National Museum of Nature and Science of Japan.
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