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Volume 26, Issue 1
Displaying 1-24 of 24 articles from this issue
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Reiko HAYASHI, Toshiko JOBO, Hiroyuki KURAMOTO1987 Volume 26 Issue 1 Pages 1-6
Published: 1987
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSA pilot study of the screening for endometrial carcinoma was performed to 4, 283 women who were asymptomatic and hoped to have the screening for uterine cancer by using endometrial cytology, and to evaluate the usefullness of the non-selected method of screening.
Two cases who showed positive smear were experienced, one of which was diagnosed as endometrial cancer i.e. 0.02% of the cancer detection rate. Another one was a false positive case who was realized to have IUD i.e. 0.02% of the false positive rate.
Those factors which are reportedly related to higher detection of endometrial cancer such as age, histories of nuli-gravidity and menopause and so-called complications of the carcinoma were evaluated. Our results conclude that those factors are no longer significant among the series of asymotomatic women, and instead emphasize the necessity of a selected screening system which is restricted in the group of women who show some symptom of genital bleeding in order to detect endometrial carcinoma with reasonable frequency.View full abstractDownload PDF (5240K) -
Norio CHIWATA, Tadashi SUGISHITA, Norikoto ISHIDA, Hiroshi SATO, Tadas ...1987 Volume 26 Issue 1 Pages 7-14
Published: 1987
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSIn the present study, the cytological examination was performed on cervical human papillomavirus (HPV) infection with no dysplasia during the follow-up period. The subjects enrolled in this study were 6 cases in total including 1 case followed up for 5 years and 5 cases followed up for 1.6-3.0 years.
1) In the diagnostic cytology, the evidences which have been established so far concerning the cytology of cervical HPV infection could be applied to the cytological follow-up for a long term period. Koilocytes did not always appear upon every observation time, dyskeratocytes appeared frequently. Binucleation, amphophilic cells, giant cells and eosinophilic background were observed only sporadically case by case.
2) Some identifiable findings which were observed in individual cases throughout the follow-up course attracted our attention in this study, that is, the appearance of metaplastic cells accompanied with inmature cells in 4 cases, the appearance of koilocytes in 1 case and giant cells and binucleation in 1 case.
3) In one case of warty atypia the course of which could be followed up for 5 years, less findings suggestive of HPV infection were obtained cytologically as well as histologically but only colposcopy revealed the presence of this disease in the beginning of the follow-up period. However, only cytology indicated this disease with no or weak evidence by colposcopy or histology in the latter stage. It is thus considered that the follow-up diagnosis of cervical HPV infection must be performed cooperatively by mean of colposcopy, cytology and histology.View full abstractDownload PDF (12448K) -
Koichi KUBOTA, Ken YAMAZAKI, Tokuzo KASAI, Hideaki IWASAKI, Bin TAKEDA ...1987 Volume 26 Issue 1 Pages 15-22
Published: 1987
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSCytologic and histologic studies were performed on 166 cases of cervical HPV infection, which were cytologically detected by mass-screening of uterine cancer.
1) 77 (46.4%) of cervical HPV infection were encounted in 30th. and 63 (38%) in 40th. The relative frequency figures seemed to be inversely related to the age of the patients.
2) Keratosis was detected in 41 (24.7%) by cytology and in 15 (9%) by histology.
3) Koilocytotic lesions (KL) were histologically shown in 79 (47.6%). KL and neoplasia coexisted in 5 (3%). Pure neoplasia without KL was detected in 24 (14.5%).
4) The histologic patterns of 79 KLs were as follows, flat type 76, endophytic type 3. Of these, 7 presented such marked cytologic atypia that they were reported as atypical condyloma.
5) Endophytic type was supposed to be derived from the cervical glands which were occupied by KL as glandular involvement.View full abstractDownload PDF (9056K) -
Naohiro OIKAWA, Toshihiko TOKI, Toru TASE, Yuichi WADA, Akira YAJIMA, ...1987 Volume 26 Issue 1 Pages 23-28
Published: 1987
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSThe presence of HPV antigen on koilocytes noted on uterine cervical smears was studied according to the immunoperoxidase method, and their ultrastructure was observed by both scanning electron microscopy (SEM) and transmission electron microscopy (TEM).
The results obtained were as follows:
1) The presence of HPV antigen in nucleus was confirmed in a few koilocytes by the peroxidase-antiperoxidase (PAP) method.
2) SEM film revealed some koilocytes with specific three-dimensional structure in the depressed center of the cell body.
3) TEM film showed an electron microscopically unformed portion without cytoplasmic organella around the nuclei of koilocytes. Further, virus particles thought to be HPV were noted in the nuclei of a few koilocytes.View full abstractDownload PDF (10403K) -
Noboru KOIKE, Tatsuo HIGUCHI, Yoshitaro SAKAI1987 Volume 26 Issue 1 Pages 29-34
Published: 1987
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe investigated the cytological characteristics of the socalled atrophic pattern of normal vaginal smears in 711 elderly women, ranging from 60 to 98 years of age, and the histopathologic background of the cytology of these atrophic vaginal smears, using autopsy materials from another 54 elderly women, ranging from 65 to 100 years of age.
The results were as follows:
The atrophic pattern of vaginal smears was found in 375 cases and the non-atrophic pattern in 336.
Therefore, the ratio of the former to the latter was almost one to one. This ratio was not influenced by aging.
The atrophic pattern of these vaginal smears was divided into four main types and their subtypes: syncytial cell type (S type), naked cell type (N type), round cell type (R type) and polygonal cell type (P type), with degenerated and distorted cell subtypes in all four categories.
The syncytial cell type was found in 46.1%, making it the most numerous. This type was assumed to be the basic pattern for atrophic smears.
When the epithelium of the vaginal wall of the 54 autopsy cases was divided into evolutional and involutional types, the former was found in 21 cases (38.9%) and the latter in 33 (61.1%). Both types were found in every decade from the 60s to the 90s.
The evolutional type was found in a specimen from a 100-year-old woman.
In the involutional type the epithelium was composed of four to eight layers of parabasal cells and these cells were morphologically, compatible with atrophic cells of the S, N, R and P types.View full abstractDownload PDF (10953K) -
Ayako SASAKI, Norio OBATA, Shoshichi TAKEUTI, Etuko NAGAI1987 Volume 26 Issue 1 Pages 35-42
Published: 1987
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe studied histopathologically seven cases of adenoma malignum of the uterine cervix were studied.
The results were as follows:
1. The cases ranged in age from 35 to 58 years, with a mean age of 48 years.
2. The clinical symptoms and signs of seven cases were vaginal bleeding, vaginal discharge, and hypertrophy of the cervix.
3. The clinical staging (FIGO) varied stage four cases, of stage Ib two cases of stage II and case of stage III.
4. Six cases were treated by radical hysterectomy and pelvic lymph node dissection. Two cases with pelvic lymph node metastasis were treated by operation plus irradiation, but showed tumor recurrence and died within three years.
5. The Papanicolaous classification of the initial smear test obtained by scraping was class III in five cases, class IV in one and class V in one.
6. The cytologic characteristics of the cervical smear were 1) clean background appearance, 2) multilayered or side-by-side arrangement of tumor cells, 3) abundant lacy or vacuolated cytoplasms, 4) round or oval nuclei with occasional prominent nucleoli, 5) granular chromatin pattern, and 6) increased N/C ratio.
7. The histological diagnosis of the initial cervical biopsy specimens was adenoma malignum in only two cases and atypical glands and/or cervicitis in five.View full abstractDownload PDF (13487K) -
Fumio HORIUCHI, Syoji OHKI, Toshiyuki OKADA, Bin TAKEDA, Hideaki IWASA ...1987 Volume 26 Issue 1 Pages 43-48
Published: 1987
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSDetection of Chlamydia trachomatis (C. trachomatis) was attempted in 161 biopsy specimens histologically diagnosed as cervicitis by immunoperoxidase staning (peroxidase antiperoxidase method, PAP) or partly by direct immunofluorescent method.
1. 52 out of 161 (32.3%) cases proved to be positive by PAP method.
2. Age occurrence rates of C. trachomatis by PAP method are as follows;-30; 26.7%, 31-40; 33.3%, 41-50; 33.3%, 51-60; 35.3%, 61-; 16.7%.
3. Chlamydia infected cells are mainly in columnar area followed by in squamous metaplasia and in squamous epithelia.
4. Positive localization of C. trachomatis by PAP method was observed in apical portion of cytoplasm adjacent to nuclei, while positive round inclusion bodies were rere occurrence (5.8%).View full abstractDownload PDF (4086K) -
1. Ultrastructural study of culture cell with Chlamydia-infectionKeiji KERA, Fumio HORIUCHI, Bin TAKEDA, Yoshio SHIINA, So HASHIZUME, H ...1987 Volume 26 Issue 1 Pages 49-56
Published: 1987
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSElectron microscopic studies were performed on chlamydia-infected HeLa cells as fundamental research in clinical cytology.
(1) HeLa cells in the relatively early stage of infection were characterized by dominant reticulate bodies, and showed smaller inclusion bodies with lesser numbers but more densely packed masses of chlamydia.
(2) Cells of later stages exhibited increased numbers of intermediate and elementary bodies, and large inclusion bodies oppressing the nucleus.
(3) In the final stage, chlamydia decreased in number in inclusion bodies with loose scattering of elementary bodies inside and with distinct borders.
(4) The measured size of chlamydia was as follows: elementary body 0.36±0.02μm, intermediate body 0.47±0.07μm, reticulate body 0.68±0.44μm.
(5) Ultrastructural changes in HeLa cells with chlamydia infection were relatively slight, compared with other microorganic infections, in nucleus and organella, except for the oppressed nucleus and inclusion-body formation.View full abstractDownload PDF (15316K) -
2. Ultrastructural study of Chlamydia-infected cell of the human uterine cervixKeiji KERA, Fumio HORIUCHI, Bin TAKEDA, Yoshio SHIINA, Akira ISHIKAWA, ...1987 Volume 26 Issue 1 Pages 57-63
Published: 1987
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBiopsy specimens from the uterine cervix were studied electron microscopically in 24 suspected cases of chlamydia infection. Chlamydia-infected cells were examined ultrastructually in two cases.
(1) Cells with chlamydia were detected singly or in groups mainly in superficial and partly in intermediate layers of squamous metaplasia adjacent to the squamo-columnar junction.
(2) Besides squamous metaplasia of columnar origin, chlamydial inclusion bodies were found in several types of columnar cells, including mucous-producing cells of cervical glands.
(3) Chlamydial inclusion bodies were located in the cytoplasma adjacent to the nucleus, were round or slightly irregular in shape and 5-10μm in size, and differed in populations of elementary, intermediate and reticulate bodies according to the phase of infection.
(4) Cellular changes by chlamydia infection were remarkable in nucleus and organella, though inclusion bodies and nuclear oppression were often encounted.
(5) Many intracytoplasmic lumina were noted, requiring morphological differentiation from chlamydia inclusion bodies on a microscopic level.View full abstractDownload PDF (10620K) -
Ko-ichi NAGASAKA, Masafumi ISHIKAWA, Hirosato IWASE, Bin TAKEDA, Susum ...1987 Volume 26 Issue 1 Pages 64-70
Published: 1987
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSCytological studies were performed on urethral infections due to Chlamydia trachomatis (C. trachomatis) in male patients. Ninety-three urethral scrapings from patients with symptoms and signs of urethritis were investigated. Direct Papanicolaou-stained smears were compared with those of immunofluorescence (IF) and immunoperoxidase (PAP) methods.
In the Papanicolaou-stained smears, urethral cells with vacoulated, mucoid, reticular and granular inclusions were present in gonococcal urethritis (25%) and nongonococcal urethritis (38%). In contrast, the PAP reaction on Papanicolaou-destained smears for these inclusions was negative. In cases with inclusion-bearing cells, C. trachomatis was demonstrated in 72% of cases by both IF and PAP methods. In gonococcal urethritis, the detection rate of C. trachomatis was 25% with the IF method and 33% with the PAP method. In contrast, in nongonococcal urethritis, the detection rate was 52% with the IF method and 36% with the PAP method. With the IF method, typical elementary and reticulate bodies were observed in intracellular as well as extracellular spaces in the urethral specimens. In the PAP test, most of the positive granules in columnar epithelial cells were located in the Golgi area. None of the cases demonstrated C. trachomatis as an inclusion form in either the IF or PAP method. Nearly 26% of men with gonococcal urethritis were coinfected with C. trachomatis.
Detection of C. trachomatis infections is exremely difficult by routine Papanicolaou, Giemsa and periodic acid-shiff stainings. Thus, immunocytochemical techniques such as the IF and PAP methods will undoubtedly be of great diagnostic value for detecting C. trachomatis infections in male patients.View full abstractDownload PDF (4174K) -
Yoshio UEI, Kiyozo KISHI, Yuji SHIOSAWA1987 Volume 26 Issue 1 Pages 71-76
Published: 1987
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSIn order to obtain good specimens suitable for automated cervical cancer screening, cervical scrapings of 147 cases including 13 cancer and 134 non-cancer ones were suspended in a saline solution. Specimens were made by the method previously reported. Those of 102 cases (69%) were suitable for automated cytology containing sufficiently dispersed cells without cellular clumps, excessive number of polymorphonuclear leukocytes or erythrocyte debris.
Next to examine cell loss and cell recovery during preparation, cancer and/or atypical cells in a pretreated specimen and the corresponding routine cervical one were counted up to 30 cells in total. Specimens containing more than that were regarded as the “same” in number. There were 64 cases (63%), which contained more or the “same” number of cancer and/or atypical cells, whereas the rest, 38 cases (37%), did less number of those cells. This fact must be taken into consideration for automated cancer cytology.View full abstractDownload PDF (3490K) -
Yasuyoshi ISHII, Masahiko FUJII, Setsuko FUKAHORI, Ichiro SAKUMA, Kei ...1987 Volume 26 Issue 1 Pages 77-82
Published: 1987
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSThe concentration method using YM fixative solution was applied to sputum cytology of 82 patients with lung cancer and its efficacy was examined.
Procedure of this method is as follows: Morning-cough sputum collected by a series of three days is stored in a Mucous sol tube (Muto Pure Chem. Co. Ltd., Tokyo) containing YM solution. The solution is then centrifuged at 1, 500 rpm for five minutes, and the sediment is smeared on the clean glass slides thinly coated with 0.1% poly-L-lysine. After air drying, smears are re-fixed in 95% ethyl alcohol and stained by the modified Papanicolaou's method.
The overall accuracy was 76.8%(63/82 cases) in the smears made by this method. Malignant cells could be detected in 27 (87.1%) out of 31 squamous cell carcinomas, 22 (64.7%) out of 34 adenocarcinomas, 13 (86.7%) out of 15 small cell carcinomas and one (50%) out of two large cell carcinomas. Examined patients contained 34 surgical cases. Of these surgical cases, malignant cells were identified in 24 cases (70.6%). Using this method, positive results were obtained in 13 (61.9%) out of 21 cases with clinical stage I cancer, in seven (87.5%) out of eight cases with stage II cancer, in 27 (77.1%) out of 35 cases with stage HI cancer and in 13 (76.5%) out of 17 cases with stage IV cancer. Also, 44 (83.0%) out of 53 cases showing abnormal bronchoscopic findings and 16 (59.3%) out of 27 patients without bronchoscopic alterations were positive in the smears made by this method.
The results in the present study indicate that this procedure is a simple and reliable method for sputum cytology and is useful not only in hospital but also in mass survey.View full abstractDownload PDF (5755K) -
Fumiaki TEZUKA1987 Volume 26 Issue 1 Pages 83-86
Published: 1987
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSThe knowledge of precancerous condition of the liver could be of practical value for early detection of hepatocellular carcinoma. In this study, the cytometrical analysis was done on the cirrhotic portions of 16 livers with hepatoma and of 17 livers without hepatoma. The following parameters of hepatocytic nuclei were estimated on histologic sections NVO, the number of nuclei in a unit volume of liver tissue; D, the mean of nuclear diameters; S, the standard deviation of nuclear diameters (i.e. the degree of anisokaryosis); and N/C, the nucleoplasmic volume ratio. Nvo and N/C were significandy larger, and D and S smaller in cirrhotic livers with hepatoma than in those without hepatoma (p<0.05). This result suggests that the cirrhotic parenchyma of livers with hepatoma, which is regarded to be in precancerous condition, could be characterized by hyperplasia of small hepatocytes with increased ratio of N/C.View full abstractDownload PDF (3030K) -
Masamichi OIKAWA, Tadahiro SUZUKI, Kuniharu ISHIOKA, Yoko MIURA, Tai S ...1987 Volume 26 Issue 1 Pages 87-94
Published: 1987
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe performed cytodiagnosis of pancreatic juice, bile and duodenal juice in 232 cases of malignancies arising in the pancreas and biliary tract during the past ten years, to evaluate the diagnostic value of cytologic examination. In the cytology of duodenal juice obtained by pancreozymin or caerulein-secretin test, malignant cells were identified in 17 of 72 patients (24%) with cancer of the pancreas, two of 13 patients (15%) with cancer of the bile ducts, none of seven patients (0%) with cancer of the gallbladder and four of ten patients (40%) with cancer of the ampulla of Vater. In the cytology of pancreatic juice or bile obtained by endoscopic duct aspiration, malignant cells were identified in 17 of 38 patients (45%) with cancer of the pancreas, four of 11 patients (36%) with cancer of the bile ducts, one of three patients (33%) with cancer of the gallbladder and all of three patients (100%) with cancer of the ampulla of Vater. In the cytology of bile obtained by percutaneous transhepatic cholangiodrainage, malignant cells were identified in 17 of 47 patients (36%) with cancer of the pancreas, 32 of 58 patients (55%) with cancer of the bile ducts, nine of 20 patients (45%) with cancer of the gallbladder, three of 13 patients (23%) with cancer of the ampulla of Vater and two of six patients (33%) with cancer metastasized or invaded to the bile ducts. Positive rates of cytodiagnosis varied from 0 to 100% depending on the site of cancer. However, malignant cells were frequently found in patients who were subject to operative cure. Therefore, Therefore, the cytology of pancreatic juice, bile and duodenal juice was proved to be useful for early detection of pancreatic and biliary tract cancer.View full abstractDownload PDF (3092K) -
Yoshiro EBIHARA, Kumiko SASAKI, Yoko MAEDA, Masako SHIMIZU, Tsuyoshi O ...1987 Volume 26 Issue 1 Pages 95-101
Published: 1987
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSFive cases of early breast cancer, in which exfoliative cytology of abnormal nipple discharge was only a means of detecting malignancy and no tumor mass was discovered even by recent progressed techniques such as echography, are reported.
The cytological materials obtained from the mammillary discharge showed clusters of varing numbers of atypical cells, counting to 50 in most instances but rarely up to 1, 000. Each smear specimen had a bloody background containing numerous foamy histiocytes in addition to the tumor cell clusters. The tumor cells in general were small in size with hyperchromatic nuclei measuring about 9 micron each in their longer diameter.
Histologically, each resected breast tissue had multiple minor cancer lesions in the fibrotic breast tissue, forming to vague tumor mass but intraductal papillary carcinoma, clinging carcinoma and/or cancerization of lobules in the collecting ducts and the lobules beneath the mamilla. Minimal stromal invasion was present in some of the cases. These cancer lesions were compatible with the origin of the tumor cells in the nipple discharge.
Exfoliative and histological characteristics of early breast cancer were comparatively discussed.View full abstractDownload PDF (9426K) -
Akinori ISHIHARA, Akira KAMIMORI, Tamiko KIMURA, Nobuo KITABATAKE, Kun ...1987 Volume 26 Issue 1 Pages 102-109
Published: 1987
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe morphologically examined the intracytoplasmic lumina (ICL) in tumorous lesions of the breast by imprint cytology.
The ICL was demonstrated by staining with Papanicolaou, Periodic acid Shiff, Alcian blue, May Grünwald Giemsa and CEA staining using immunohistochemical methods.
The ICL appeared as round or oval shaped vacuoles, ranging in size from 2 to 18μm (median, 5.9μm). The ICL was morphologically classified into two types. One was characterized by the presence (Type I) or absence (Type II) of secretory materials in the lumen. Electronmicroscopic examination of type I showed cytoplasmic vacuole with wellformed microvilli projecting towards the lumen and various amounts of secretory materials, whereas the type II had vacuole with only scanty microvilli.
In cases of carcinoma of the breast, the ICL was observed in 51% of the cytological cases. On the other hand, the incidence of the ICL among non-malignant lesions was only 0.5%. The frequency of ICL was greater in cases of scirrhous carcinoma than those of the other type of carcinoma of the breast.
These ICL may be a helpful cytologic feature in the diagnosis of breast carcinoma.View full abstractDownload PDF (12647K) -
Mikio ARAKAWA, Takashi ENDO, Mikio SHIMIZU, Matsuko SANO, Takayuki NOJ ...1987 Volume 26 Issue 1 Pages 110-115
Published: 1987
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe classified 26 cases with pulmonary adenocarcinoma into three subtypes (well, moderately and poorly differentiated adenocarcinoma) according to the degree of histologic differentiation, and studied the cytomorphologic characteristics of cancer cells of three subtypes exfoliated in sputum specimens.
The cells of the well-differentiated type revealed formation of papillary clusters. Vacuoles were observed in the cytoplasm. The nuclei were small and relatively uniform. The chromatin pattern was usually finely granular and nucleoli were small.
The cells of the moderately differentiated type usually appeared singly or in loose groups. The nuclei were medium sized. The chromatin pattern was finely granular. The nucleoli were medium sized.
The cells of the poorly differentiated type were observed singly, loosely and in a plane arrangement. The nuclei were large and varied in size. The nucleoli were also large.View full abstractDownload PDF (3878K) -
Seisen YOH, Hiroshi OOHASHI, Masatomo KITAZONO, Tamio MITAMURA, Michia ...1987 Volume 26 Issue 1 Pages 116-123
Published: 1987
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe present the case of a 46-year-old woman with primary malignant lymphoma of the uterine cervix, clinical stage IVA in the Ann Arbor classification, which was incidentally detected by cytodiagnosis in mass screening for cervical cancer and definitely diagnosed by the findings at exploratory laparotomy and autopsy.
This case was classified as non-Hodgkin's lymphoma, diffuse and mediumsized cell type, in the ISG (Lymphoma Study Group of Japan) classification. The Papanicolaou smear from the mass screening showed large numbers of scattered tumor cells. Small clusters of cells were also demonstrated occasionally. The background was almost clean, but contained a small amount of cellular debris. Individual tumor cells were moderately large in size and appeared round to oval in shape with a sparse cytoplasm. The nuclei, with a moderate degree of hyperchromasia and delicate chromatin, appeared oval in shape. Some of them seemed to be so-called cleaved nuclei, having prominent complex nuclear membrane infoldings and dentations. They also had one to two prominent irregular shaped nucleoli. Mitotic figures and mirror-image nuclei, which are said to be one of the characteristics of Hodgkin's disease, were also observed.View full abstractDownload PDF (12436K) -
Harumi KOMODA, Shigeki NUNOKAWA, Isao MATSUDA, Masafumi UENAKA, Chiaki ...1987 Volume 26 Issue 1 Pages 124-128
Published: 1987
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe report a case of Sertoli-Leydig cell tumor (SLCT) with a dermoid cyst in a 53-year-old-Japanese housewife. Hypertrichosis was noticed in the face and legs, but laboratory examination was unremarkable including hormone activities in the blood and urine. Left ovarial tumor was a relatively solid, which was histologically poorly differentiated Sertoli-Leydig cell tumor, and one ovoid cyst, which was a matured teratoma with skin appendages, thyroid tissue and cartilage in its wall.
Imprint smears obtained from a cut-surface of the tumor showed atypical cells having oval nuclei with coarse or fine chromatin and prominent nucleoli, and scanty cyanophilic cytoplasm. In addition, atypical cells having large and round nuclei, and plenty cytoplasm with many vacuoles were observed. Those seemed to be the cells of Leydig cell differentiation. The presence of those cells is important to diagnose SLCT in imprint cytology of the ovarial tumor.View full abstractDownload PDF (4538K) -
Shigeyuki SUGIE, Takuji TANAKA, Naoki YOSHIMI, Hideki MORI, Masayoshi ...1987 Volume 26 Issue 1 Pages 129-133
Published: 1987
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSA case of ovarian granulosa cell tumor diagnosed by aspiration cytology in a 72-year-old woman is described. In the aspiration cytology, tumor cells with coffee bean-like nuclei were noted and they showed a Call-Exner body and rosettelike structures. These findings indicated the granulosa cell tumor in ovary although she had a few hormonal symptoms due to the tumor. Histology of the neoplasm at autopsy showed the cylindroid or trabeculoid type but not the folliculoid type of granulosa cell tumor and confirmed the cytological diagnosis.View full abstractDownload PDF (8904K) -
Five cases reports of ovarian and endometrial cancersMasahiro OKAWADA, Ryuichi KUDO, Kentoku KUMAI, Fuyuyo ASAI1987 Volume 26 Issue 1 Pages 134-140
Published: 1987
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSCytological observations were made on the morphological changes and number of tumor cells, as well as on rational changes of mesothelial cells, lymphocytes, histiocytes and neutrophils, following chemotherapy using cisplatin and other anticancer drugs in combination in four advanced cases of ovarian cancer and a case of endometrial cancer associated with ascites. These five cases were studied, and the results were as follows:
1) An decrease in the number of malignant cells was observed in the cases in which chemotherapy was effective.
2) Nuclear enlargement, cell enlargement, cytoplasmic vacuolation, partial aggregation of chromatin and disappearance of mitotic cells were prominantly observed in the cases in which chemotherapy was effective.
3) The ratio of mesothelial cells deceased markedly in the effectively treated cases. In contrast, the ratio of lymphocytes was increased or less decressed in the effectively treated cases.View full abstractDownload PDF (7030K) -
Report of two casesTamotsu TAKAHASHI, Chihiro ICHIHARA, Hiroshi SONOBE, Yohzoh OHHASHI1987 Volume 26 Issue 1 Pages 141-145
Published: 1987
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSTwo cases of urachal carcinoma of the urinary bladder, which were diagnosed from findings of cystoscopy and urine cytology, are described. Case 1 was a 78-year-old female, case 2 a 61-year-old female. Macrohematuria was the only complaint in both patients. In both cases cytoscopy revealed a tumor in the apical region of the urinary bladder, and urine cytology showed well-or moderately differentiated adenocarcinoma cells with mucin production. While the urinary sediment included adenocarcinoma cells in case 2, in case 1 adenocarcinoma cells were disclosed in a mucinous jellylike substance floating after centrifugation but not in the urinary sediment.View full abstractDownload PDF (9463K) -
A case reportNoboru KOIKE, Yukito YAMAMOTO, Yoshitaro SAKAI1987 Volume 26 Issue 1 Pages 146-150
Published: 1987
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSCytologic findings in pleural effusions from a 38-year-old man with recurrent medullary carcinoma of the thyroid were described.
In Pap.test, malignant epithelial cells showed spindle or sometimes round cytoplasm, and round nuclei composed of loose clusters.
Occasionally, the tumor cells resembled mesothelial cells or macrophages. Malignant cells were characterized by coarse granular chromatin and cytoplasmic fine granules that stained red in Giemsa staining.
PAS-positive granules were located in peripheral cytoplasm, and no Congo-red-positive particles were present.
Immunocytochemical staining of carcinoembryonic antigen (CEA) was especially useful for differential diagnosis.View full abstractDownload PDF (8419K) -
Report of a caseHiroshi SONOBE, Shunichi MANABE, Tamotsu TAKAHASHI, Eiji OHARA, Machik ...1987 Volume 26 Issue 1 Pages 151-156
Published: 1987
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSCytologic and histopathologic findings of a primary squamous cell carcinoma arising in the thyroid gland are reported together with the histogenesis. The patient, a 38-year-old male, complained of hoarseness and dyspnea of three weeks' duration. The thyroid, 10 × 5 cm in size, was diffusely enlarged. Laryngoscopy revealed a papillomatous nodule in the right false vocal cord. Total thyroidectomy and laryngectomy were performed, based on the diagnosis of double cancers in the thyroid and larynx.
In touch smears made from fresh tissues of the thyroid tumor, large polygonal cells with atypia were observed, revealing a sheet-like pattern and tendency for keratinization. In addition, a number of rather small and undifferentiated tumor cells were found. Macroscopically, the tumor, measuring 6×5×3 cm, was located in the isthmus of the thyroid and invaded into the both lobes, surrounding soft part and tracheal wall, resulting in tracheal stenosis and mucosal ulceration. The tumor also showed extensive submucosal lymphogenous spread from the trachea to the larynx, and metastasized to the right false vocal cord as a papillomatous tumor, 0.5 cm in diameter. Apart from these lesions, a thyroglossal duct cyst including a squamous component was present near the hyoid bone. Histologically, the tumor corresponded to moderately differentiated squamous cell carcinoma, keratinizing type, and was composed of tumor cells with predominantly clear cytoplasm. Histogenetically, the thyroid tumor was considered to originate from the remnant of the thyroglossal duct, because of its median location and the presence of the thyroglossal duct cyst near the hyoid bone.View full abstractDownload PDF (10394K)
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