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Volume 28 (1989)
- Issue 6 Pages 739-
- Issue 5 Pages 603-
- Issue 4 Pages 477-
- Issue 3 Pages 327-
- Issue 2 Pages 167-
- Issue 1 Pages 1-
Volume 28, Issue 4
Displaying 1-14 of 14 articles from this issue
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Hitoshi HANEDA, Hiroshi ISOBE, Hiroshi MIYAMOTO, Yoshikazu KAWAKAMI1989 Volume 28 Issue 4 Pages 477-482
Published: 1989
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe determined the nuclear DNA content from archival paraffin-embedded specimens of 90 lung adenocarcinomas. Patients were divided into subgroups, and nuclear DNA content and the prognosis were compared between subgroups.
Mean DNA index (DI) of all patients was l.76± 0.56 (mean± SD), and DNA aneuploidy was observed in 72 patients (80.0%). Mean coefficient of variation for the tumor G0/G1 peak was 4.11.
Alveolar cell carcinoma had a trend of smaller DI, but it was not significant when compared to the other subtypes. Patients with a high differentiation grade tumor or alveolar cell carcinoma had a better prognosis (<0.05), while cuboidal cell type had an inclination to metastasis to the lymph nodes earlier than the other types.
Columnar cell type with mucus had a greater DI (mean=2.25), and its smoking index was higher (mean= 1300) than the other types of adenocarcinoma. The distribution of DI of different cellular subtypes was similar to that of the smoking index. This indicates that smoking habits infl uence pathogenesis and the DI in this type of adenocarcinoma.View full abstractDownload PDF (4048K) -
Takashi YAMADA, Hideo SASAKI, Chikara YAGASHIRO, Toshihiro SHIBATA, Yo ...1989 Volume 28 Issue 4 Pages 483-493
Published: 1989
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSAsbestos bodies and/or their allied particles were detected in the sputum or bronchial washings of 16 cases. Various types of asbestos bodies were found whose characteristic morphologies were demonstrated by light microscopy and scanning electron microscopy. Most of the allied particles detected had central cores consisting of carbon. Macrophages had ingested these particles into the cytoplasma and were expectorated with the mucus. It was particularly interesting to note that a single particle appeared to be competitively ingested by two or three macrophages.
The sixteen patients reported here consisted not only of mine workers, but also included industrial workers in the ordinary environment, and 7 and 5 patients amongst them, suffered from lung cancer and silicosis respectively.View full abstractDownload PDF (17593K) -
Masakatsu FUKASAWA, Akira YOSHIDA, Sadahiko SHIGEMITSU, Hideyuki TANAK ...1989 Volume 28 Issue 4 Pages 494-500
Published: 1989
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe quantied 17 cytologic findings in aspiration cytology specimens in order to determine the diagnostic value of each finding.
In 101 cases of breast disease (50 carcinomas and 51 benign diseases), the degree of the respective cytologic findings was quantified by the appropriate scales. Then, the category score and the coefficient value of each cytologic finding were calculated by using multivariate statistical analysis.
The following cytologic findings showed high coefficient values; distribution of chromatin, nuclear shape, chromatin pattern, naked bipolar nuclei, intercellular connection, and paired cells. These were considered to be important in the diagnosis of breast diseases. The distribution of “total category score” was quite different in malignant and benign cases. In addition, the usefulness of this category score was proved by an external check, which was performed on 20 additional cases.View full abstractDownload PDF (4333K) -
Toshihiko IZUTSU, Toshinari TAKAHASHI, Atsumi KATASHIMA, Chisei KAWAMU ...1989 Volume 28 Issue 4 Pages 501-504
Published: 1989
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSHematoidin crystals are rosette-shaped crystalline aggregates of radially arranged needles measuring from 2 μm to 100μm and stained either yellowish or brownish by the Papanicolaou stain. One to 28 hematoidin crystals are present in one smear.
Hematoidin cyrstals were prospectively searched for from May of 1987 to July of 1988.
Hematoidin crystals were observed in 21 of 100, 403 papanicolaou smears. Inflammatory cell changes were observed in 19 cases and a bloody background was observed in 7 cases out of the 21. Seven cervicovaginal smears were obtained from pregnant and postpartum women among the 21 cases.
Histochemical stains were prepared for 16 of the 21 cases.
The histochemical method used included periodic acidshiff (PAS), Alcian blue stain, iodine stain, Belin blue stain, and an immunohistochemical stain (ferritin).
The PAS stain was positive for hematoidin crystals, but all the other histochemical and immunohistochemical stains were negative.
It was suggested that hematoidin crystal are composed of a protein-carbohydrate complex rather than bilirubin or iron.View full abstractDownload PDF (5906K) -
Shinji KAKUMU, Koji KATSUTA, Ryuichi YATANI1989 Volume 28 Issue 4 Pages 505-509
Published: 1989
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSThe patient was a 78-year-old man. He was first found to have a right cluneal tumor. A chest roentgenogram confi rmed a large anterior mediastinal mass.
The tumor cells consisted of epithelial cells. These cells appeared collectively or as isolated cells. The cells were small with round or spindle-form nuclei, and the cytoplasm was relatively scant. The nuclei were finely granular and had evenly distributed chromatin and indistinct nucleoli. Mitotic figures were rarely present.
At autopsy, a firm mass was observed within the anterior mediastinum. The tumor measured 15×10×4cm in its greatest dimensions and hemorrhage and necrosis of the central area were observed. Tumor invasion was not present in the pleura, pericardium, diaphragm, or lung, although distant metastases were found in the left and right lung, liver, left clavicle, left sixth costa, and right ilium.
The tumor was composed predominantly of epithelial type cells with hemorrhage and necrosis. Cytologically, part of the tumor cells had a coarse granular pattern of the nuclei. These characteristics seemed to suggest the malignant behavior of the tumor.View full abstractDownload PDF (8626K) -
cytomorphological comparison with small round cell tumorTaku KATOH, Hisao TAKAHASHI, Fugio ENDOH, Bin TAKEDA, Fumio HORIUCHI, ...1989 Volume 28 Issue 4 Pages 510-515
Published: 1989
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSLight & electron microscopic and immunohistochemical studies were performed on smear and biopsy of skin Merkel cell carcinoma. Noticeable findings are EMA, keratin, NSE and Neurofilament immunohistochemically positive, and dense by electron microscope. Button-like findings in the cytoplasm by papanicolaou staining were immunohistochemically positive for neurofilament, and topologically consistent with intermediate filament of ultramicroscopic structure. These fi ndings are characteristic and serve for differential diagnosis from other small round cell tumors. But Merkel cell carcinoma lacking neurofilament resembles pulmonary small cell carcinoma both cytomorphologically and immunohistochemically. Diagnostic differences of them depend on electron microscopic examination.View full abstractDownload PDF (7211K) -
Masao MORIKAWA, Eiko NAKAHARA, Hiroyuki NAKATSUKA, Sachie ISHIZAKI, Ta ...1989 Volume 28 Issue 4 Pages 516-521
Published: 1989
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSImprint smears were obtained from two chordomas which developed in the sacrum of an 8-year-old male and in the coccyx of a 40-year-old female. Chordoma cells were examined morphologically and immunocytochemically.
In both chordomas, there were three kinds of tumor cells: physalipherous, stellate, and intermediate cells. With respect to their immunocytochemical characteristics, all three types contained EMA, cytokeratin and keratin, markers indicating epithelial cell origin. Moreover, they all were positive for S-100 protein, NSE and vimentin, markers indicating non-epithelial cell origin. Stellate cells and intermediate cells were CEA-positive, but physalipherous cells were not.
These results indicate that the three kinds of tumor cells composing chordomas may be of the same lineage, although they are morphologically different.
Furthermore, it was thought that immunocytochemical evaluation was useful in the cytological diagnosis of chordoma, because chordoma cells have characteristics of both epithelial cells and non-epithelial cells.View full abstractDownload PDF (8212K) -
Shigeharu HATAKEYAMA, Keiko GOTOH, Hisako TAKAKUWA, Chieko KUMAGAI, Te ...1989 Volume 28 Issue 4 Pages 522-528
Published: 1989
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSA case of histologically confirmed duct papilloma of the breast with unusual myoepithelial cell proliferation studied by aspiration biopsy is reported.
Cytologically, aspirated cells were divided into three types as follows.
The first type of cells were spindle-shaped with welldefined cytoplasm, despite the pale staining, and oval nuclei showing no marked nuclear pleomorphism, and displayed a fi nely granular chromatin pattern. Almost all cells showed inconspicuous nucleoli. They were arranged in large irregular bundles or a whirl-like pattern with strong cellular cohesiveness. The cytologic findings suggested non-epithelial cells, but the origin is unknown. Retrospectively, these cells were considered to be derived from myoepithelial cells.
Immunohistologically, these cells reacted positively for S-100 protein, actin and keratin by the avidin biotin peroxidase complex technique. The second type of cells appeared as sheet-Iike and smooth, with a relatively regular arrangement of the cells, the nuclei were round to oval and the nuclear chromatin showed a finely granular pattern with small nucleoli. The cluster contained a small number of fiber-like cells with spindle-shaped nuclei near the center. From the morphological characteristics these cells were considered to be derived from papillomatous lesions.
The third type were apocrine metaplastic cells which showed abundant foamy cytoplasm, and the nuclei were round with prominent nucleoli.View full abstractDownload PDF (13492K) -
Yutaka MASUDA, Katsuji OKUI, Takao HANAWA, Etsuo HORINAKA, Takenori AD ...1989 Volume 28 Issue 4 Pages 529-533
Published: 1989
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSA case of anal endometriosis in 32-year-old woman is reported. The patient complained of anal pain and a palpable solid nodule. Anal pain varied in relation to menstruation. A complete surgical excision was performed. The touch smears of anal endometriosis showed the grandular epithelial cells and the stroma cells.
Epithelial cells appeared as cluster and monolayered sheets of uniform cells. Nuclear forms were round or oval with one or two nucleoli. The cytoplasm were stained as moderate basophillic with mucine by Papanicolaou staining and these cytoplasmic borders were not well preserved. The stroma cells appeared sometime as a cluster, but the cytoplasm was not clear. Nuclear size was about 5-μ in diameter and form was oval. Histiocytes with cytoplasmic hemosiderin and the mitotic cells were not recognized. The nuclei of both cells had a bland chromatine pattern.
Recently, sphincter preserving operation is popular for benign anal diseases. Therefore, we emphasized that oversurgical excision is contra indication for anal endometriosis.View full abstractDownload PDF (4373K) -
Nobuzo IWA, Yoshitaka TABARU, Masami IMAKITA, Hatue UEDA, Chikao YUTAN ...1989 Volume 28 Issue 4 Pages 534-536
Published: 1989
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSA case of human papilloma virus (HPV) infection to the urinary sediments in a 56 year-old female was studied by cytology and immunocytochemistry.
The characteristic cellular changes of condyloma accuminata like koilocytosis and dyskeratosis were observed in the urinary cytology. These cells may closely mimic those shed from condyloma cells from the uterine cervix. They showed smudged and dark nuclei having a perinuclear halo zone. The HPV antigen was detected by ABC staining with the reaction products in the nucleus.
We think that the atypical cells in the urinary sediments probably were urethral in origin from an asymptomatic patient with no apparent genital warts.View full abstractDownload PDF (3619K) -
Taku KATOH, Hisao TAKAHASHI, Takashi KIYOKAWA, Bin TAKEDA, Fumio HORIU ...1989 Volume 28 Issue 4 Pages 537-542
Published: 1989
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSA rare case of 50 years old endometrial mucinous carcinoma is reported, arising on left corner of bicornous uterus with single cervix. Cervical smear showed orangephilic degenerative glandular cells. Endometrial smear exhibited cell clusters with abnormal overlaping, but with less atypia. Some signet ring cells with minimum atypia were observed in these cells. Macroscopic findings of tumor was 6.0×3.5cm papillary neoplasia on the left corner of bicornous uterus. Histology indicated mucin producing papillary carcinoma. Histochemically, tumor cells were both PAS and Alcian-Blue positive and immunohistochemically CEA positive and partly Alkaline phosphatase positive. Electron microscopic figures showed absorptive epithelial cells resembling intestine cells, and goblet cells with secreting granules.View full abstractDownload PDF (9990K) -
Toshihiko TOKI, Toshihiko MORI, Yuko NAKANOMYO, Akira YAJIMA1989 Volume 28 Issue 4 Pages 543-546
Published: 1989
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe report a case of adenoacanthoma of the endometrium in a 29-year-old woman in which a group of cells resembling a “morule” was detected by endometrial cytology. Numerous groups of adenocarcinoma cells were examined cytologically and, in some of these scattered, mature squamous cells were seen.
In addition, groups of relatively immature squamous metaplastic cells arranged in sheets were observed and were considered to correspond to morule. In the excised specimen, an exophytic tumor had developed from the posterior uterine wall and the case was diagnosed histopathologically as adenoacanthoma accompanied by numerous morules.View full abstractDownload PDF (7743K) -
Masatomo KIMURA, Takao SATOU, Eizi KADOTA, Kurenai TANJI, Shingo HIRUM ...1989 Volume 28 Issue 4 Pages 547-551
Published: 1989
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe experienced a case of bronchopulmonary aspergillosis associated with splenic candidiasis and tried to diagnose the proliferative fungus in the lung as Aspergillus (the second most frequently found pathogenic fungus of visceral mycosis next to Candida), based only on the morphological features.
The patient, a 43-year-old female, was found to be suffering from recurrent acute promyelocytic leukemia and subsequently died. Autopsy revealed Aspergillus pneumonia of the middle and lower lobes of the right lung, and also hemorrhagic pleuritis. A simple cavity was detected in the left upper lobe which included necrotic material. We could verify by smear cytology that the necrotic material of the adherent portion and that inside the cavity included Aspergillus mycelia. Those were Y-formed dichotomous mycelia showing a progressive pattern of proliferation. However, histological examination of the histologic sections did not provide enough information about the fungal shape to recognize Aspergillus. Candidal structure was also observed more clearly by smear cytology than in the histological specimens.
Therefore, smear cytology seems very useful in the diagnosis of fungal infection, especially Aspergillus infection, and should be routinely adopted in any such cases of fungal infection.View full abstractDownload PDF (3653K) -
Tohru TACHIBANA, Riyoutarou YAMADA, Masaru MURATA, Yoshitaka OHMACHI, ...1989 Volume 28 Issue 4 Pages 552-554
Published: 1989
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSDownload PDF (3948K)
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