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Volume 37, Issue 5
Displaying 1-21 of 21 articles from this issue
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Maya SASAKI, Ryutaro NAKASHIMA, Sigeko NAKAMURA, Sumiko YAMAZAKI, Hiro ...1998 Volume 37 Issue 5 Pages 449-454
Published: September 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSObjective: The application of sputum cytology in lung cancer screening for detection of adenocarcinoma was studied.
Study Design:Sputum cytologic specimens at lung cancer screening in patients with adenocarcinoma of the lung detected by chest x-ray film were re-evaluated. One hundred fifty-four specimens from 80 patients were available for this study.
Results: Among 48 patients with adenocarcinoma screened by both sputum cytology and chest x-ray, 14 (29%) were detected by both chest x-ray and sputum cytology. Of the 34 specimens diagnosed as negative at the year of detection, six and one were judged to be positive and to be suspective positive, respectively. Cytological findings which had been overlooked at screening included a few small clusters of atypical cells with slight hyperchromasia and low N/C ratio.
Conclusion: Atypical cells which were estimated to be derived from adenocarcinoma were observed in sputum cytologic specimens of twenty-one patients (44%) with adenocarcinoma.View full abstractDownload PDF (6276K) -
Toshiro KAWAI, Takeshi FUJII, Shinji SAKURAI, Ja-Mun CHONG, Ken KURIKI ...1998 Volume 37 Issue 5 Pages 455-459
Published: September 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSObjective: To identify factors influencing the cytologic diagnostic accuracy of bile obtained through percutaneous transhepatic cholangiography and drainage (PTCD) for pancreatic cancer.
Study Design: we retrospectively reviewed a series of 1010 specimens from 163 patients bearing pancreatic cancer. We also evaluated the correlation between the cytologic diagnostic accuracy of PTCD-obtained bile and pathological factors including the extent of invasion into the intrapancreatic bile duct, total bilirubin values and histological factors, in 55 patients who had undergone surgical resection of pancreatic cancer.
Results: 1. The overall sensitivity of PTCD-obtained cytologic specimens for pancreatic cancer was 52.8%.
2. Increasing numbers of cytologic specimens correlaed with a higher rate of positivity.
3. The numbers of specimens examined in false negative cases tended to be fewer than those in positive cases.
4. The positive ratio per examination was 21.8% in pancreatic cancer-bearing patients.
5. PTCD bile cytology for pancreatic cancer not exposed to the bile duct lumen, was negative. The ratio of positive cytologic specimens correlated to the extent of ivasion into intrapancreatic bile duct.
6. Serum bilirubin values also correlated with the extent of invasion into the intrapancreatic bile duct. Five cases of pancreatic cancer, not exposed to bile duct lumen, caused obstructive jaundice.
7. The diagnostic accuracy in patients with moderately differentiated tubular adenocarcinoma was higher than that in patients with well differentiated adenocarcinoma.
8. The diagnostic accuracy of PTCD-obtained bile did not correlate with tumor size or amount of stroma.
Conclusion: In pancreatic cancers, the cytologic diagnostic accuracy of PTCD-obtained bile was influenced by the extent of invasion into the intrapancreatic bile duct.View full abstractDownload PDF (631K) -
Katsuyuki TAKAOKA, Yoshio SUZUKI, Osamu MATSUZAKI1998 Volume 37 Issue 5 Pages 460-464
Published: September 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSObjective: To investigate the role of morphometric analysis in cytological diagnosis of prostatic adenocarcinoma.
Study Design:The average nuclear diameters were measured in Papanicolaou-stained smears prepared from fine needle aspirates of ten patients belonging to each of the following four categories: benign lesions, well differentiated, moderately differentiated, and poorly differentiated adenocarcinoma. All cytological diagnoses were confirmed by histopathological studies of needle biopsies.
Result:The average nuclear diameter in each of these four groups was 10.6±1.8, 11. 3±1.6, 16.0±1.9, and 16.1±1.8 micrometers, respectively. There was no significant difference between the average nuclear diameter in benign lesions and in well-differentiated adenocarcinoma. The average nuclear diameter of moderately and poorly differentiated adenocarcinoma was significantly larger than in the other two categories.
Conclusion: It is concluded that morphometric analysis of nuclei is of no value in cytological diagnosis of welldifferentiated adenocarcinoma, but that this method is a useful adjunct in cytological diagnosis of moderately and poorly differentiated adenocarcinoma.View full abstractDownload PDF (6905K) -
Michiko SAITO, Takenori TSUBOI, Yoshie HAYASHI, Kyoko YUTO, Atsuko KAD ...1998 Volume 37 Issue 5 Pages 465-468
Published: September 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground:Papillary squamous cell carcinoma (PSCC) of the uterine cervix is a very rare type of squamous cell carcinoma.
Case:We report a case study of a 43-year-old woman with PSCC. The distinctive cytological findings were numerous malignant squamous cells and a few big cell clusters. The surface of the clusters were covered with 10-15 layers of atypical cells and the clusters had a fibrovascular core. The shape of the cluster was similar to the transitional cell carcinoma of the urinary tract.
Conclusion: In some cases of PSCC biopsy cannot detect the invasion. Cytology is therefore useful for detecting PSCC invasion.View full abstractDownload PDF (6706K) -
Masanari NODA, Eiki ITO, Satoko YAMASHITA, Noriyuki AKUTAGAWA, Katsuma ...1998 Volume 37 Issue 5 Pages 469-474
Published: September 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground:Carcinoid tumors in theuterine cervix are rare, but prognosis is poor.
Case:A 30-year-old Japanese woman complaining of genital bleeding and lower abdominal pain was diagsnosed with stage II a carcinoma of the uterine cervix. Pathology and histology indicated either small cell non-keratinizing squamous cell carcinoma or undifferentiated carcinoma. Despite neoadjuvant chemotherapy (LDC-FBOMP) and radical hysterectomy accompanied by radiation therapy, the patient died of recurrence of the tumor 9 months after the neoadjuvant chemotherapy.
Histologically the tumor was composed of small undifferentiated cells with oval hyperchromatic nuclei and scant cytoplasm. The nests of tumor cells were separated by thin fibro-vascular stromata. Argyrophilic tumor cells were identified by Grimelius stain. These cells were positive for chromogranin, NSE, GO-a and 5-HT. By ultrastructural study, neurosecretory-like granules measuring about 200-440 nm were also observed.
Conclusion: The carcinoid tumor of the uterine cervix had a grave clinical course. Though histological, histochemical and ultrastructurfal studies are necessary to diagnose carcinoid tumors, the early detection of such highly malignant tumors is very important.View full abstractDownload PDF (9208K) -
Manami IMAI, Toshiko JOBO, Masao IAMP, Tadayuki KANAI, Masumi TOYONAGA ...1998 Volume 37 Issue 5 Pages 475-480
Published: September 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground:Metastatic uterine carcinoma derived from extra-genital organs is very rare. Most metastatic uterine carcinomas are derived from gastric carcinoma and that from breast carcinoma is rare in Japan.
Cases:We encountered two cases with metastatic uterine carcinoma from breast carcinoma (one case with invasive ductal carcinoma, and the other with invasive lobular carcinoma).
Conclusion: The characteristic findings of the cytology obtained by Endocyte in these two cases are as follows;
1. A few malignant cells were found with abundant normal endometrial cells.
2. The background is clear.
3. The nuclear chromatin increased and is finely granulated and the nuclei has one or two nucleolei.
4. Every cluster is small in size.
5. Intracytoplasmic lumina are present.
6. In the case with invasive lobular carcinoma, small clusters appeared in an indian file arrangement.View full abstractDownload PDF (10186K) -
Yoshinori KOYAMA, Akira ASOU, Isamu SUGANO, Toshitaka NAGAO, Yasuo ISH ...1998 Volume 37 Issue 5 Pages 481-485
Published: September 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSCase:We report a case of a mature cystic teratoma with sebaceous carcinoma (SC) transformation. A 76-year old woman noticed abdominal distention ten years before referral. The right resected ovary was 19 cm in the greatest dimension and contained fatty debris. A nodular lesion of cyst wall measuring 5 cm in diameter was composed of atypical basaloid cells forming nests with foamy clear cells in their centers, consistent with sebaceous carcinoma. Electron microscopy disclosed fat droplets in the cytoplasm.
Conclusion: Cytologically, some tumor cells had large nuclei and pale foamy cytoplasm and were intermingled with basaloid cells, findings compatible with the cytologic appearance reported of SC.View full abstractDownload PDF (7144K) -
Yoshiko NAKAYA, Mikiko ARIGA, Kazunori IWASA, Taisuke KUROKAWA, Yoshia ...1998 Volume 37 Issue 5 Pages 486-489
Published: September 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground:Acinic cell carcinoma is not a rare tumor in the salivary gland. Although the histopathology has been well-characterized recently, cytologic features has not been described well.
Cases:Case 1 was a 25-year-old female. Operation for a recurrent tumor in the parotid gland as performed, and imprint cytology of the resected tumor was done. Case 2 was a 67-year-old female. Biopsy specimens of the recurrent palatine tumor were punched out and imprint cytology was done for the tissues. Cytology specimens showed papillary clusters of tumor cells. Especially in case 1, a tombstone appearance around capillaries was noted. Tumor cells had eccentric nuclei and vacuolated or foamy cytoplasms.
Conclusion: These cytologic findings were consistent with characteristic histological findings of this tumor, and are important findings for the diagnosis of acinic cell carcinoma.View full abstractDownload PDF (6893K) -
Tsuyoshi KATAOKA, Takahiko GOTOH, Rumi HARUTA, Miyo ODA, Katsunari OGA ...1998 Volume 37 Issue 5 Pages 490-494
Published: September 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground:Breast tumors in pregnant women must be definitively diagnosed before surgery is performed because of the risk to the fetus. Recently, we experienced a rare case of ductal adenoma in a first trimester pregnancy which was difficult to differentiate from breast cancer.
Case:The patient was a 39-year-old woman (6th week of pregnancy). She presented to our hospital with a chief complaint of bilateral breast tumors. The right breast tumor was 2.5 cm in diameter and had a well-defined margin, leading to a cytological diagnosis of fibroadenoma. The left breast tumor was an ill-defined induration. Since fine needle aspiration cytology revealed atypical cells, the patient underwent wide excision of the left tumor at the 14th week of pregnancy (after the period of fetal organ formation)
Cytological findings were a well-circumscribed border, oval nucleus, and apocrine metaplasia. However, nuclear atypia with an increased amount of chromatin and an enlarged nucleolus, and an irregular cell arrangement pattern were also seen. Atypical ductal hyperplasia or duct carcinoma in situ was suspected due to marked cellular proliferation with a cribriform appearance. The left resected tumor was thin and reddish brown, leading to a histopathological diagnosis of benign ductal adenoma.
Conclusion: We reported a rare case diagnosed as having a ductal adenoma of the breast in a first trimester pregnancy. Since the preoperative diagnosis is difficult in pregnant women with the breast lumps, it is necessary to have more careful follow-up including several cytological examinations.View full abstractDownload PDF (7154K) -
Hideharu DOMOTO, Mikio ANZAI, Shintaro TERAHATA, Kimiya SATO, Seiichi ...1998 Volume 37 Issue 5 Pages 495-499
Published: September 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground:In glycogen-rich clear cell carcinoma of the breast (GRCC) more than 90% of the neoplastic cells have glycogenated clear cytoplasm. This rare carcinoma accounts for only about 0.9-3.0% of all breast neoplasms. We report a case of typical GRCC with cytologic findings of fine needle aspiration biopsy.
Case:A 35-year-old female visited our hospital complaining of a palpable left breast mass in early January 1997. A tumor approximately 2.0 cm was palpated and breast cancer was suspected by radiological examination. Cytological diagnosis of fine needle aspiration biopsy was issued as Class 4. She underwent quadrantectomy with dissection of lymph nodes on March 9. Histologically, proliferation of clear cells with glycogen accumulation in the cytoplasm was noted in both the mammary duct and infiltrating area, and the diagnosis of GRCC was made. Cytological findings were as follows: distinct cell boundary (similar to vegetable cells), clear and vacuolated or fine granular cytoplasm, round nuclei with various sizes, and single and enlarged nucleoli appearing slightly red. These cytological findings were similar to those of previously reported GRCC.
Conclusion: Aspiration cytological findings of GRCC have not been well defined due to its rarity. Whether or not GRCC is a distinct entity and should be classified as a separate entity of breast neoplasms remain controversial. Cytological diagnosis of GRCC may be possible before surgery. Further study is needed to determine the diagnostic value of GRCC and its distinct features.View full abstractDownload PDF (6673K) -
A case reportToshitsugu Nakamura, Masahiko Shimomura, Motoo Yajima, Asako Yagi, Kan ...1998 Volume 37 Issue 5 Pages 500-504
Published: September 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Atypical parathyroid adenoma is a borderline neoplasm defined by histological findings, while its cytological characteristics have not been described so far.
Case: A 43-year-old man was diagnosed as primary hyperparathyroidism due to parathyroid tumor by medical check-up as a momentum. Although the extirpated tumor was welldemarcated by fibrous capsule, a few small tumor nests were observed in the capsule, which fulfilled the histological diagnostic criteria of atypical adenoma. Some of the tumor cells had giant and/or hyperchromatic nuclei, with intranuclear cytoplasmic inclusions in part, which may be used in favor of an estimation of adenoma rather than carcinoma. In addition, there were few mitotic figures in the tumor tissue and Ki-67 labeling index was as low as that in the conventional parathyroid adenomas.
Conclusion: It is suggested that the present case is biologically akin to the conventional adenoma and that nuclear atypy and low proliferative activity are useful findings to estimate parathyroid neoplasms to be benign in the cytological specimens.View full abstractDownload PDF (5822K) -
Kimiya SATO, Shintaro TERAHATA, Mikio ANZAI, Hideharu DOMOTO, Seiichi ...1998 Volume 37 Issue 5 Pages 505-509
Published: September 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Mixed neuroendocrine-neural tumor is a rare tumor that is composed, in part, of pheochromocytoma, but also has a component of neuroblastoma, ganglioneuroblastoma, or ganglioneuroma. We report a case of mixed neuroendocrine-neural tumor of the adrenal gland.
Case: A 64-year-old female was referred to our hospital because of hypertension with elevated serum and urine levels of catecholamines. A left adrenal tumor was detected on CT scan and resected as pheochromocytoma. Grossly, the tumor was composed of tan to gray-white nodular areas, whitish myxoid areas and cystic areas with bloody content. In imprint smears, the cytological findings included two different patterns. One was a sheet-like arrangement of polygonal cells containing granular cytoplasm and oval nuclei, while the other was aggregates of ganglion-like cells with small spindle cells. Histopathological diagnosis was mixed neuroendocrine-neural tumor composed of pheochromocytoma and ganglioneuroma. Some “intermediate” cells that expressed features of both pheochromocytes and ganglion cells were also observed.
Conclusion: When pheochromocytoma is suspected, careful cytological and histological examination should be undertaken to exclude mixed neuroendocrine-neural tumor.View full abstractDownload PDF (7413K) -
Masato SAGESHIMA, Akira FUJITA, Tomiko FUJIWARA, Satoru ITO, Seiko WAT ...1998 Volume 37 Issue 5 Pages 510-514
Published: September 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: The presence of cancer cells of urachal adenocarcinoma in urine specimens is relatively rare. We report three cases of adenocarcinoma arisen from the Urachal remnant and discussed the differential diagnosis between adenocarcinoma and transitional cell carcinoma cytologically.
Cases: All of these patients complained of hematuria and a few malignant cells were detected in urine cytology. Among three cases, transitional cell carcinoma was suspected in one case. The main reason for this wrong diagnosis was probably loss of tall columnar appearance of the cytoplasm of adenocarcimoma cells by degeneration and the rare occurrence of adenocarcinoma in the urinary bladder.
Conclusion: To make an accurate diagnosis of adenocarcinoma in urine specimens, the findings of tall columnar cytoplasms in which the nuclei is located at one side of the cytoplasm, papillary pattern and the cells with signet ring type should not be overlooked.View full abstractDownload PDF (9836K) -
Masaomi SASAKI, Kenichi WAKASA, Tomoko HABA, Yoshihiro IKURA, Shinich ...1998 Volume 37 Issue 5 Pages 515-519
Published: September 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSCase: We report a case of large granular lymphocytic leukemia with tumor cells in cerebrospinal fluid (CSF). The tumor cells had abundant pale blue cytoplasm with partial azurophilic granules and small-to medium-sized nucleus with a smooth nuclear margin. The number of cells was not increased, in CSF. It was difficult to distinguish between malignant cells and reactive lymphocytes.
Conclusion: An in situ hybridization kit (Epstein-Barr virus encoded small RNA prode, Dakopatts, Denmark) was used in Papanicolaou-destained CSF smears. EB-RNA was detected in all atypical lymphocytes. The lymphocytes infiltrating cerebrospinal fluid were considered to be tumor cell. EB-RNA was also detected in the liver biopsy specimens of this patient.View full abstractDownload PDF (6318K) -
Junko KAYAO, Jun-ichi TAMARU, Shosuke SUNAMI, Takeyuki SATO, Tadashi S ...1998 Volume 37 Issue 5 Pages 520-524
Published: September 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Burkitt's lymphoma has been classified into two subtypes: African and Non-African type, according to genetic differences, and chromosomal abnormalities. The present case is a rare Non-African type, characterized by dislocation of chromosome t (2; 8).
Case: A 6-year-old boy, had been diagnosed as Burkitt's lymphoma by lymph node aspiration cytology in 1987. Histopathological findings showed a significant starry-sky appearance. Immunohistochemical findings and flow cytometrical and karyotype analysis data were described. Neoplastic cells were decided to be B-cell type by various examination. They had a basophilic cytoplasm with microvesicular structure, characterized by positive staining for lipid. Karyotype analysis disclosed a t (2; 8) dislocation. Immunological examination showed no elevation of Epstein-Barr virus (EBV) antibody.
Conclusion: These features appeared to be compatible with those seen in Extra-African type Burkitt's lymphoma. The patient is now uneventful and under follow-up.View full abstractDownload PDF (7972K) -
Nobuyoshi FURUTANI, Kazuaki YAMADA, Shotaro MAEDA1998 Volume 37 Issue 5 Pages 525-529
Published: September 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: We report a case of primary malignant melanoma of the brain.
Case: A 56-year-old male, presented with a chief complaint of decline in attensiveness and initiative accompanied by headache. Metastatic carcinoma of the brain was detected by CT, MRI and angiography of the brain. Tumorectomy was performed and the histopathologic diagnosis was malignant melanoma. Large atypical cells with a high N/C ratio were revealed in the cytology of spinal fluid. However, it was difficult to diagnose this case as malignant melanoma by cytology alone because the cells were lacking melanin pigment. The patient's condition was improved by chemotherapy, but increased melanin pigment and obvious nucleoli in the cytology of spinal fluid proved this case as malignant melanoma.
Conclusion: Cytological findings of spinal fluid at the autopsy were almost the same as the cytological findings during chemotherapy. Peritoneal dissemination was considered to be the result of V-P shunt, but the majority of the cells in peritoneal fluid were histiocytes which had devoured melanin pigments and a few melanoma cells mainly in the peritoneum of the Douglas pouch.View full abstractDownload PDF (9147K) -
Shousuke UEDA, Tamotsu TAKAHASHI, Masayo WADA, Miho ICHIEN, Eriko MIYA ...1998 Volume 37 Issue 5 Pages 530-536
Published: September 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Cytologic description of pineal parenchymal tumors are extremely rare. We report a case of mixed pineocytoma-pineoblastoma with spinal metastasis. Proliferative activity of this rare tumor was also examined.
Case: A pineal tumor was detected in a 9-year-old girl who had congenital microcephalus. Imprint and squash cytology of the resected tumor showed small uniform cells with round to oval nuclei and focal rosette-like structures. A small number of relatively large cells with hyperchromatic nuclei were also observed. Histologically, the tumor was composed of a pineocytoma area with pineocytomatous rosette and highly cellular pineoblastoma area with Homer Wright rosette. Spinal fluid cytology revealed pineoblastoma cells with relatively large, hyperchromatic and pleomorphic nuclei with scanty cytoplasms. The MIB-1 positive rate of the pineocytoma area was 2.5% and that of pineoblastoma area was 36.7%.
Conclusion: The high proliferative potential of the pineoblastoma component may relate to tumor relapse and spinal metastasis.View full abstractDownload PDF (13066K) -
Masayo WADA, Tamotsu TAKAHASHI, Shousuke UEDA, Miho ICHIEN, Eriko MIYA ...1998 Volume 37 Issue 5 Pages 537-540
Published: September 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Lipoblastoma is a rare benign neoplasm seen mostly in infants and young children and can be mistaken for a liposarcoma or other lipomatous tumors. Cytologic study of this rare tumor is exceedingly rare and has only been reported in 4 cases.
Case: A tumor was detected on the back of a 6-monthold male. Fine needle aspiration cytology was performed and the tumor was diagnosed as lipoblastoma. The characteristic features on the cytologic smears were the presence of multivacuolated lipoblasts associated with mature adipocytes. These fat cells mingled with delicate capillaries and fibrous septa-like structures. The cytologic diagnosis was confirmed by histologic study of the excised tumor.
Conclusion: Distinction of lipoblastoma from liposarcoma, which is extremely rare in infancy, is made possible by the absence of nuclear pleomorphism and hyperchromasia in lipoblastoma. The absence of cells with granular eosinophilic cytoplasms is a important cytologic feature which distinguishes it from hibernoma, and the presence of lipoblasts discounts ordinary lipoma.View full abstractDownload PDF (4104K) -
Hiromitsu YASUMATSU, Nobutoshi TANAKA, Nobuhiro WAKABAYASHI, Yoshiro T ...1998 Volume 37 Issue 5 Pages 541-542
Published: September 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSCurschmann's spirals are frequently found in sputa of patients with lung cancer, bronchitis and pulmonary tuberculosis. It is extremely unusual to see the spirals in cervical smears. We report a case showing Curschmann's spiral in cervical smear.
A 47-year-old women, gravida two, para two, had a routine cervical smear, which showed the presence of a Curschmann's spiral with no dust-containing histiocytes. Morphologically, this spiral was indistinguishable from that found in sputum. We conclude that Curschmann's spirals in cervical smears are formed from endocervical mucus.View full abstractDownload PDF (2279K) -
Masayuki NOZAKI, Katsumi KOBAYASHI, Atsushi NAKAMURA, Ikuko YOSHIKAWA, ...1998 Volume 37 Issue 5 Pages 543-544
Published: September 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe report a case of retinoblastoma in an adult male without any family history. A 23-year-old man came to our hospital complaining of myiodesopsia in his right eye.
Funduscopic examination demonstrated a tumor on the periphery of the right fundus in the optic area.
Fine needle aspiration cytology revealed many clusters of small round cells and necrotic debris. Rosette-like formation was also present.
Immunocytochemical study of the smear showed that the tumor cells were positive for neuron-specific enolase (NSE) and synaptophysin. Extraction of the eyeball was performed and histological examination confirmed the presence of retinoblastoma.View full abstractDownload PDF (3922K) -
Shin-ichi SHIMIZU, Tetsuji YAMADA, Fumiko SAKATA, Yurika SAWAKI, Hiros ...1998 Volume 37 Issue 5 Pages 545-546
Published: September 22, 1998
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe report the cytologic features of chondroblastoma of the right patella in a 15-year-old boy. Imprint cytology specimen, prepared from frozen sections, contained many mononuclear cells and multinucleated giant cells. Mononuclear cells had round to ovoid shaped bland nuclei with fine chromatin and inconspicuous nucleolus. The characteristic features of these cells were irregular indentation of nuclei, nuclear grooves, and only a few intranucicar pseudoinelusions. Mitoses were absent. Chondroid matrix could not be identified in cytologic specimen, but these nuclear findings were considered to be highly suggestive of chondroblastoma.View full abstractDownload PDF (3638K)
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