Background: Atypical parathyroid adenoma is a borderline neoplasm defined by histological findings, while its cytological characteristics have not been described so far. Case: A 43-year-old man was diagnosed as primary hyperparathyroidism due to parathyroid tumor by medical check-up as a momentum. Although the extirpated tumor was welldemarcated by fibrous capsule, a few small tumor nests were observed in the capsule, which fulfilled the histological diagnostic criteria of atypical adenoma. Some of the tumor cells had giant and/or hyperchromatic nuclei, with intranuclear cytoplasmic inclusions in part, which may be used in favor of an estimation of adenoma rather than carcinoma. In addition, there were few mitotic figures in the tumor tissue and Ki-67 labeling index was as low as that in the conventional parathyroid adenomas. Conclusion: It is suggested that the present case is biologically akin to the conventional adenoma and that nuclear atypy and low proliferative activity are useful findings to estimate parathyroid neoplasms to be benign in the cytological specimens.
Curschmann's spirals are frequently found in sputa of patients with lung cancer, bronchitis and pulmonary tuberculosis. It is extremely unusual to see the spirals in cervical smears. We report a case showing Curschmann's spiral in cervical smear. A 47-year-old women, gravida two, para two, had a routine cervical smear, which showed the presence of a Curschmann's spiral with no dust-containing histiocytes. Morphologically, this spiral was indistinguishable from that found in sputum. We conclude that Curschmann's spirals in cervical smears are formed from endocervical mucus.
We report a case of retinoblastoma in an adult male without any family history. A 23-year-old man came to our hospital complaining of myiodesopsia in his right eye. Funduscopic examination demonstrated a tumor on the periphery of the right fundus in the optic area. Fine needle aspiration cytology revealed many clusters of small round cells and necrotic debris. Rosette-like formation was also present. Immunocytochemical study of the smear showed that the tumor cells were positive for neuron-specific enolase (NSE) and synaptophysin. Extraction of the eyeball was performed and histological examination confirmed the presence of retinoblastoma.
We report the cytologic features of chondroblastoma of the right patella in a 15-year-old boy. Imprint cytology specimen, prepared from frozen sections, contained many mononuclear cells and multinucleated giant cells. Mononuclear cells had round to ovoid shaped bland nuclei with fine chromatin and inconspicuous nucleolus. The characteristic features of these cells were irregular indentation of nuclei, nuclear grooves, and only a few intranucicar pseudoinelusions. Mitoses were absent. Chondroid matrix could not be identified in cytologic specimen, but these nuclear findings were considered to be highly suggestive of chondroblastoma.