We compare the features of tumor imprint cytology (TIC) with those of fine needle aspiration cytology (FNAC) in a case of anaplastic malignant peripheral nerve sheath tumor. A 56-year-old female patient with von Recklinghausen's disease presented with a subcutaneous tumor, measuring 3×3cm, in her back. TIC yielded from the surgically resected tumor containing mainly MFH-like large neoplastic cells which possessed bizarre nuclei; however, FNAC showing an admixture of large bizarre cells and spindle-shaped cells. We suggest that this discrepancy is caused by the difference in exfoliation between anaplastic bizarre tumor cells and spindle-shaped ones.
Cytological findings of a case of elastofibroma dorsi are described. A 58-year-old female presented with a slowgrowing mass in the left subscapular region. The excised lesion measuring 6×4×3cm was an ill-defined white elastic mass. Scraping cytological specimens showed benign-appearing spindle cells and light-green stained, bead string-like or globular structures, which were intensely stained with elastic fiber staining. Ultrastructurally, the structures were composed of electron-dense materials with cores of thin filaments. The spindle cells showed fibroblastic differentiation with intermediate filaments. Immunohistochemically, the cells were positive for vimentin, α-smooth muscle actin and desmin, indicating mvnfihrnhlastir or fibroblastic differentiation.
A 72-year-old male was found to have an abnormal shadow in the right lung. FNA smears showed several clusters of atypical columnar cells, some of which had hyperchromatic nuclei with irregular nuclear margin and large nucleoli. These cells were diagnosed as adenocarcinoma but the resected lung tumor was diagnosed histologically as organizing pneumonia. In order to avoid a false-positive diagnosis of the hyperplastic bronchiolo-alveolar cells, it was thought to be important to note not only the low cellularity of atypical cells but also the presence of benign columnar cells which bear some resemblance to severe atypical cells.