A 61-year-old man who died of adrenocortical carcinoma is reported. Stump specimens were prepared from the cut surface of a metastatic tumor in the liver obtained by autopsy. The specimens showed a necrotic background with numerous apoptotic bodies. The tumor cells formed loosely cohesive clusters. The nuclei showed atypia and anisonucleosis and the cytoplasm was granular or vacuolated. Mitotic figures were occasionally observed. These findings were compatible with a diagnosis of adrenocortical carcinoma, but the tumor cells resembled those of a renal cell carcinoma or hepatocellular carcinoma both cytologically and histologically.
We report a case of adenoid cystic carcinoma of the breast. A 48-year-old female presented with a solid mass with a cystic region measuring 1.7×1.5 cm in the left breast. The radiological differential diagnosis included phylloides tumor, fibroadenoma, and carcinoma. Intraoperative histological frozen section examination did not reveal any typical features of adenoid cystic carcinoma. Imprint smears from the breast tumor showed many spherical clusters predominantly composed of small round cells with finely granular chromatin, suggestive of myoepithelial cells, and also cells with relatively large nuclei, suggestive of epithelial cells.
A case of BCG-related lymphadenitis is presented. After BCG vaccination, an enlarging mass was noted in the left axillary region of a 1-year-old boy. Imprint smear cytology of the extirpated lesion revealed aggregates of epithelioid and tingible-type histiocytic cells without a necrotic background. Histologically, the lesion showed granulomatous nodules composed of epithelioid histiocytic cells and Langhans' giant cells without associated caseous necrosis. Immunohistochemically, the epithelioid histiocytic cells were positive for and-BCG antibody, lysozyme and CD 68. It is necessary to distinguish this BCG-related lymphadenitis from tuberculous lymphadenitis.
We describe a case of uterine leiomyosarcoma associated with acute infection. A 56-year-old woman presented with atypical genital bleeding. Endometrial cytology revealed isolated bizarre spindle-shaped or fibrous cells. The cytological diagnosis was malignant mesenchymal tumor (probably uterine leiomyosarcoma). She underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy. Macroscopically, the intramural tumor showed massive hemorrhagic areas and necrosis. Histologically, the tumor showed smooth muscle differentiation with marked cytologic atypia and increase in mitotic figures, and the diagnosis was leiomyosarcoma.