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Takako SHIRAI, Haruko JIMBO, Koji MATSUMOTO, Takahiro KASAMATSU, Michi ...
2001 Volume 40 Issue 2 Pages
107-113
Published: March 22, 2001
Released on J-STAGE: November 08, 2011
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Objective: To clarify whether pregnant women with uterine cervical intraepithelial neoplasia (CIN) III can be followed-up until delivery or conization during pregnancy is necessary.
Patients and Methods: We analyzed 9 pregnant patients with CIN III who were treated at the Saitama Cancer Center between 1992 and 1998. At the time of their first visit, every pregnant patient was examined by cytology, colposcopy, and directed punch biopsy. These combined methods were performed during pregnancy and after delivery in patients who wanted to be managed without conization. Conization and vaporization were performed using a YAG laser.
Results: Seven patients were managed without conization during their pregnancy. After delivery, 5 patients received conization and 2 patients received a total abdominal hysterectomy (TAH). Among these 7 patients, the clinical and cytohistological findings of all the cervices were persistent and no microinvasive carcinomas were found during the operative procedures after delivery. All of the patients had normal vaginal deliveries. Conization was performed during pregnancy in two patients. One of these patients had severe dysplasia (SD) and the other was diagnosed as having an adenocarcinomatous lesion on the basis of the biopsy specimen obtained at the time of the first visit.
Conclusion: Pregnant patients with CIN III can be safely followed-up using a combination of diagnostic techniques (cytology, colposcopy and biopsy) until and after delivery. However, when the cytohistological diagnosis during pregnancy is suspicious of cervical adenocarcinoma, further clinical evidence must be obtained before a decision regarding the need for conization can be made.
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Takashi UMEZAWA, Setsuko HARUMA, Yukiko KANETSUNA, Yoshio MIYAZAWA, Hi ...
2001 Volume 40 Issue 2 Pages
114-120
Published: March 22, 2001
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Objective: Glassy cell carcinoma (GCC) is rare in uterine cervical carcinoma. Cytological findings of GCC have not been fully clavified.
Study design: Six cases of GCC were seen from 1994 to 2000 in our department. Mean age of patients was 54.5 year old (38 to 75 years). Patients mainly reported abnormal genital bleeding. The clinical stage of was Ib 2 in 1, II a in 1, IIb in 1 and IIIb in 2. Five were treated by radical hysterectomy. One patient died of cancer soon after biopsy and therapy. In initial cytological examination, GCC was diagnosed in 4 and large cell nonkeratinizing squamous cell carcinoma in 2. GCC was diagnosed in 5 hysterectomy specimens and one biopsy specimen histologically.
Results: Cytologically tumor cells showed polygonal, nuclear pleomorphism and often a giant cell pattern. Their cytoplasm was finely granular and abundant. Nuclei showed a large, oval, hyperchromatic and irregular peripheral configuration. The chromatin pattern of nuclei showed a coarsely granular and irregular distribution, and nucleoli were prominant and multiple in a bizarre nucleus. There was no evidence of tubulo-papillary structure or keratinization. Cytological characteristics were compatible with histological findings.
Conclusiton: Cytologically, GCC showed polyhedral cells, cellular pleomorphism, large ovoid nuclei with prominent nucleoli and finely granular cytoplasm, which must be important in diagnosing GCC cytologically and it is important to keep this in mind when cytologically diagnosing uterine cervical tumors.
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Makoto AKABOSHI, Jun WATANABE, Takeshi FUJISAWA, Manabu HATTORI, Eiji ...
2001 Volume 40 Issue 2 Pages
121-127
Published: March 22, 2001
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Objective: Expression of cdk 2 and Ki-67 in endometrial carcinoma was studied immunohistochemically and the correlation of expression compared to histopathological grade and p 53 expression.
Study design: cdk 2, Ki-67, and p 53 expression was examined in 104 patients with endometrial endometrioid carcinoma, including 69 with well-differentiated (G 1), 24 with moderately differentiated (G 2), and 11 with poorly differentiated (G 3) adenocarcinoma. Immunohistochemical staining was conducted with labeled streptavidin biotin. Labeling indices of cdk 2, Ki-67, and p 53 were calculated by counting approximately 1200 cells. The staining pattern was classified as diffuse, partial, or sporadic.
Results: Immunoreactivity for cdk 2, Ki-67, and p 53 was observed in the nuclei of tumor cells. Labeling indices of cdk 2 (G 1: 10.9±14.3%, G 2: 18.4±16.2%, and G: 25.6±22.8%), and Ki-67 (G 1: 50.1±23.9%, G 2: 53.6±19.9%, and G 3: 66.3±17.4%) correlated significantly with high histopathological grade. cdk 2 expression correlated significantly with that of p 53. The dominant staining pattern of cdk 2 in G 1 was sporadic and in G 2 was partial, and significant difference were seen between the 2 grades. The staining pattern of cdk 2 and Ki-67 tended to be diffuse more often in G 3.
Conclusion: More dominant expression of cdk 2 and Ki-67 was significant in high histopathological grade, and the staining pattern also tended to be diffuse.
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Tomoyasu KATO, Kahori SHIMIZU, Yuji ARAI, Hideo TESHIMA, Satoshi UMEZA ...
2001 Volume 40 Issue 2 Pages
128-133
Published: March 22, 2001
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Objective: We histologically diagnosed stage III or IV ovarian cancer by ascites cytology.
Study design: Ascites cytology specimens from 91 patients with epithelial ovarian cancer were reviewed and correlated with tumor histology.
Results: Of the 91, 67 (74%) were positive for ascites cytology. In 44 (81.5%) of 54 patients with serous adenocarcinoma testing rositive, 14 (78%) of 18 had clear cell adenocarcinoma, 7 (58%) of 12 had mucinous adenocarcinoma, and 2 (29%) of 7 had endometrioid adenocarcinoma. Serous adenocarcinoma was characterized by large papillary clusters, found in 33 (75%) cases. These clusters were accompanied by psammoma bodies in 16 (48%) cases. Among the 14 with clear cell adenocarcinoma, 10 (71%) showed a mirror ball pattern and 8 (56%) showed calcification in the stroma. Mucinous adenocarcinoma was marked by a sheet-like arrangement of clusters and mucin in the cyotplasm. Tubular clusters were seen only in endometrioid adenocarcinoma. These findings were present in 52 of 67 patients (78%).
Conclusion: Ascites cytology is useful in differentially diagnosing tumor histology in advanced epithelial ovarian cancer.
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Ayako HAYASAKA, Tadakatsu TSUJI, Shoko NAKAO, Shuji TERADA, Yoshinobu ...
2001 Volume 40 Issue 2 Pages
134-138
Published: March 22, 2001
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Case: A 76 year-old man was referred to evaluate a nodular shadow in the right lower lobe of the lung and mediastinal lymph node enlargement. He coughed out tumor tissue when sputum cytological examination was attempted. Tissue was prepared for cytological and pathologic examination. Atypical spindle cells and large cells with multiple nuclei were found together with small cell lung cancer cells in cytological specimens. These atypical spindle cells were not markedly stained by and-NSE immunostaining. Small cell cancer nests were surrounded by these atypical cells. Spindle cells were not markedly stained by and-NCAM immunostaining, but were stained by antivimentin and antiactin immunostaining. From these findings, we concluded that the origin of these spindle and multinuclear cells was fibloblast and myoblast cells whose growth were stimulated by the disease.
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Shinya SATO, Kazuki NABESHIMA, Yuichiro SATO, Akinobu OHNO, Yuji HINOU ...
2001 Volume 40 Issue 2 Pages
139-143
Published: March 22, 2001
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Background: Intracranial chondrosarcoma is an uncommon neoplasm that may resemble chordoma (including chondroid chordoma). It is sometimes difficult to differentiate the 2 diseases. This differentiation is clinically important because chondrosarcoma has a much better prognosis than chordoma. We report a case of intracranial chondrosarcoma and discuss its differentiation from chordoma in cytologic preparation through a comparison with 9 cases of chordoma and 1 case of chondroid chordoma in our pathology file.
Case: A 26-year-old Japanese man with an intracranial tumor involving the clivus and the medial portion of the left temporal bone underwent tumor resection. Intraoperative cytologic preparation revealed round, polygonal or spindle cells arranged without tight cell-cell adhesion in a myxoid background. Squash preparations demonstrated lacunar structures with occasional binucleate cells lacking physali phorous cells. These findings led us to diagnosis chondrosar coma. Postoperative immunohistochemical studies (S-100+, vimentin +, cytokeratins-, EMA-) supported this diagnosis.
Conclusion: Differentiation of chondrosarcoma from chordoma and chondroid chordoma can be done in cytologic preparations based on loss of tight cell-cell adhesion of epithelial cell type and lack of characteristic physaliphorous cells.
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A comparison in cytologic features of tumor cells in lymph nodes
Naoki HOSAKA, Masaru OGAWA, Toshio MATSUMOTO, Hitomi OGAKI, Susumu IKE ...
2001 Volume 40 Issue 2 Pages
144-148
Published: March 22, 2001
Released on J-STAGE: November 08, 2011
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Background: We treated 2 cases of anaplastic large cell lymphoma (ALCL) and nodular sclerosis Hodgkin's disease (NS-HD). It remains difficult to differentiate ALCL from NS-HD histopathologically without immunohistochemical techniques. We compared the cytological features of tumor cells in lymph nodes from patients using imprint cytology.
Results: The following differences were found between the 2 diseases: 1) Tumor cells mutually adhered to form a mass in ALCL, whereas lacunar cells were diffuse and inflammatory cells, such as small lymphocytes, occurred in the background in NS-HD, 2) In ALCL, tumor cells were large but relatively even in site, whereas lacunar cells in NS-HD were larger and sizes varied markedly, 3) Nuclear polymorphism and hyperchromatism were more pronounced in lacunar cells. 4) In ALCL, Reed-Sternberg (RS)-like cells were observed to have 2 nuclei, whereas Hodgkin cells and RS cells in NS-HD were larger and accompanied by a perinucleolar halo, 5) Large numbers of tumor cells having a typical doughnut-shaped nucleus were detected in ALCL but hardly any in NS-HD.
Conclusions: The above differences may provide valuable cytological information in the differential diagnosis of ALCL and NS-HD.
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A case report
Eiji IKEDA, Hitoshi ABE, Takayuki SHIOMI, Kazunari YOSHIDA
2001 Volume 40 Issue 2 Pages
149-152
Published: March 22, 2001
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Background: Intracranial hemangiopericytoma is a rare tumor that must be differentiated from meningioma due to the difference in prognosis. We report imprint cytology of an intracranial hemangiopericytoma.
Case: A 28-year-old man was admitted with visual field defect, headache, and nausea. Radiological examination revealed an intracranial subdural mass in the right parietooccipital region, and the tumor mass was surgically resected. In imprint cytology, tumor cells formed overlapping clusters of 2 types of cells. One had round to oval nuclei with mild irregular margins and coarse granular chromatin, and the other had spindle nuclei with smooth margins and fine granular chromatin. The latter cells were arranged in a line to form vascular-like tube structures, and were immunocytochemically positive for endothelial cell-specific markers CD 34 and factor VIII. With immunostaining for CD 34, abundant branching blood vessels were clearly visualized in the cluster of tumor cells. Histologically, the tumor was rich in slit-like vascular structures, some of which showed a characteristic “staghorn” appearance. Tumor cells proliferated in a solid pattern between branching vessels with diffuse pericellular reticulin formation. These histological findings were diagnostic of hemangiopericytoma.
Conclusion: Tumor cell clusters containing characteristic branching vessels were diagnostic of hemagiopericytoma. Imprint cytology with immunocytochemical staining for CD 34 is useful in diagnosing intracranial hemangiopericytoma.
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Kiyomi IKEUCHI, Hirotoshi TANIMOTO, Makiko SASAKI, Kosuke SAOO, Sachik ...
2001 Volume 40 Issue 2 Pages
153-157
Published: March 22, 2001
Released on J-STAGE: November 08, 2011
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Background: Uterine carcinosarcoma is characterized by an admixture of malignant epithelial and nonepithelial components. We report on a case of uterine carcinosarcoma with only a carcinomatous component seeu in ascites cytol ogy.
Case: A 52-year-old woman reporting abnormal uterine bleeding was admitted to our hospital. Endometrial cytology showed an irregular cluster of endometrial adenocarcinoma cells and pleomorphic spindle cells. After total hysterectomy and pelvic lymphadenectomy, histpathological examination showed heterologus uterine carcinosarcoma, including adenocarcinoma, squamous cell carcinoma, spindle cell sarcoma, chondrosarcoma, osteosarcoma, and leiomyosarcoma components. The patient died of liver metastasis 13 months after surgery. At autopsy and in ascites cytology, only a carcinomatous component was found in extrauterine lesions. Immunohistochemically, the carcinomatous component was positive for MMP-7, MMP-9, and MT 1-MMP, whereas sarcomatous components showed no staining for MMPs examined.
Conclusion: We report a case of uterine carcinosarcoma with a predominant carcinomatous component. MMPs were differentially expressed between carcinomatous and sarcomatous components, and may contribute to cell shedding from the primary tumor.
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Kazuko ABE, Noriko KIMURA, Noriko ENDO, Katsunori TAKASHIMA, Toshiharu ...
2001 Volume 40 Issue 2 Pages
158-162
Published: March 22, 2001
Released on J-STAGE: November 08, 2011
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Background: The majority of patients with cervical adenocarcinoma (CA) are generally, found to already be in an advanced clinical stage due to the difficulty of early-stage CA cytological screening. The cytological features of noninvasive CA should be defined. We report 2 cases with noninvasive villoglandular papillary adenocarcinoma (VGA) of the uterine cervix.
Case: Case 1; A 33-year-old woman was found to have abnormal cervical cells during treatment for condyloma acuminatum. Cytological smear showed many small abnormal cells with a high N/C ratio in papillary clusters in an inflammatory background.
Case 2; A 37-year-old woman reported lower abdomen discomfort and lumbago. Cytological cervical smear findings were similar to those for Case 1, with large papillary or glandular clusters of small abnormal cells with mild nuclear atypia in an inflammatory background without tumor diathesis. Histological examination revealed noninvasive VGA combined with neuroendcrine carcinoma.
Conclusion: Cytological features of noninvasive VGA are as follows: no tumor diathesis in the background, and tumor cells are small with mild nuclear atypia in papillary or glandular clusters. Irregular internuclear distance and nuclear overlapping are important features in making a dianosis.
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Koichi FUKUDA
2001 Volume 40 Issue 2 Pages
163-169
Published: March 22, 2001
Released on J-STAGE: November 08, 2011
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Background: The Bethesda system (TBS) for reporting cervical/vaginal cytologic diagnosis was developed in 1988 to make reporting of cytologic diagnosis more uniform.
Results: Borderline diagnosis termed “atypical squamous cells of undetermined significance”(ASCUS) and “atypical glandular cells of undetermined significance”(AGUS) present a problem in appropriate management. AGUS seems more important than ASCUS because the frequency of invasive cancer has been identified among women with AGUS reports.
Conclusions: The essential idea of TBS is quality assurance of cytologic diagnosis. The Papanicolaou smear is a screening test in which false-negative results will occur. We must educate physicians, patients, the media, and the legal profession about these facts to be sure patients understand the screening rather than diagnostic nature of the Papanicolaou test, that it has an identifiable but very low error rate, and therefore it must be repeated annually. The Papanicolaou smear is arguably the most cost-effective public health tool for cancer screening ever devised.
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[in Japanese]
2001 Volume 40 Issue 2 Pages
170
Published: March 22, 2001
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[in Japanese]
2001 Volume 40 Issue 2 Pages
171
Published: March 22, 2001
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The state of the art
Noboru TANAKA
2001 Volume 40 Issue 2 Pages
172-175
Published: March 22, 2001
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Wied stated in the Monograph “Cytopathology of The Uterine Cervix” Ed. Meisels and Morine, ASCP Press, that “Some tests are still going on, but they are essentially using the same old technology of the 1960 s and the 1970 s”. He evaluated the CYBEST, which we developed in 1972-1982 to be as the sublime system in the world up to the present time. The Neo Path engineering staff who developed Auto Pap, before accepted as the automated screeing system by FAD, officially offered at the meeting in Tokyo that know-how employed in CYBEST is employed in various stages of Auto Pap. This reflects Wied's description. The author presented technical know-how of the CYBEST including software program employing in CYBEST in this session. This must give significant and instructive informations for users of automation systems. Auto Map was developed in Auto Pap at our strong suggestion, following CYBEST 10 cell system. Thus, this may also give variable suggestions for the future improvement.
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[in Japanese], [in Japanese]
2001 Volume 40 Issue 2 Pages
176
Published: March 22, 2001
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David C. Wilbur
2001 Volume 40 Issue 2 Pages
177-178
Published: March 22, 2001
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Atsushi KAYUKAWA
2001 Volume 40 Issue 2 Pages
179-180
Published: March 22, 2001
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Steve G. Silverberg
2001 Volume 40 Issue 2 Pages
181-183
Published: March 22, 2001
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James Linder
2001 Volume 40 Issue 2 Pages
184-185
Published: March 22, 2001
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[in Japanese], [in Japanese]
2001 Volume 40 Issue 2 Pages
186
Published: March 22, 2001
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Toshihiko OKUHARA, Yukihiro KAWAGUCHI, Masatsugu NAITO, Masayoshi TAKA ...
2001 Volume 40 Issue 2 Pages
187-192
Published: March 22, 2001
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Purpose: Standardized preparation is desirable in cytology, due to the use of different devices. The remains problem how clinically diagnostic cells represented on smears because this is the major cause of false negative results. Liquid-based sampling using whole specimens may solve this prpblem. We confirmed the accuracy of thin-layer preparation from liquid-based sampling.
Method: Immediately after making a conventional smear, the device was rinsed in preservative fluid and dispersed cells pushed through the filter (Cyringe). Clinically diagnosable cells were concentrated by a density gradient. After sedimentation, samples redispersed in saline were placed on an automated thin layering machine (AutoCyte PREP). Conventional and thin-layer smears were compared for sensitivity and specificity.
Results: Cell debris and degenerative inflammatory cells were markedly reduced and cells stained well. Microorganisms remained. Nine cases of low-grade squamous intraepithelial lesions were detected from 242 cases using both methods. Cancer cells and dysplastic cells were more concentrated in squamous cell carcinomas.
Conclusion: Thin-layer preparation improved clinical diagnosis. The swift scanning of thin-layer smears on 13 mm circles ensure sensitivity and reliability.
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Toshihiko IZUTSU, Hideo OMI, Hisao KAWAHARA, Tadahiro SHOUJI, Teruo KA ...
2001 Volume 40 Issue 2 Pages
193-199
Published: March 22, 2001
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Objective: We studied automated screening for cervical cytology using CAS 200
TM (CAS) and Autopap 300.
Study Design: We evaluated 1481 specimens using CAS and 3232 specimens using Autopap 300.
Results: Screening was correct in 1288 of 1481 cases (87.0%). 188 of 1368 cases (13.7%) were overdiagnosed as positive and 5 of 113 (4.4%) overlooked as negative using CAS of these 2741 (84.8%) were screen review or no further review (NFS) samples, with 491 identified as process review in 3232 by Autopap 300. Of 2201 specimens (80.3%) identified as review samples, 2181 were negative and 22 suspicious or positive specimens. Autopap 300 identified 20 suspicious or positive specimens as high rank, but 1 suspicious and 1 positive specimen as low rank.
Conclusion: Autopap 300 is feasible for use in primary screening for cervical cancer under modification of cytologic criteria.
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Masatsugu UEDA, Minoru UEKI, Masao MORIKAWA, Akira SHIMIZU, Osamu NUNO ...
2001 Volume 40 Issue 2 Pages
200-203
Published: March 22, 2001
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Objective: To evaluate AutoPap usefulness in cervical screening quality control.
Study Design: We analyzed 816 previously determined negative cervical slides using AutoPap with a review rate of 20% and assessed specimen adequacy. We also analyzed quality control results for cervical cytology reported by domestic institutes in the last 3 years.
Results: Of the 816, 633 (77.6%) were scored for no further review. Of the 99 identified by AutoPap for further review, only 2 were diagnosed as mild dysplasia by manual rescreening; 18 (2.2%) could not be scored completely due to scant cellularity and 66 (8.1%) due to staining limitations or processing errors. Of 8468 negative slides from 5 domestic institutes, 16 (0.19%) were identified by AutoPap as having atypical cells.
Conclusion: AutoPap system improves the accuracy of cervical screening.
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valuation of automatic cytological diagnosis screening supporting AutoPap
Keizo NAKAYAMA
2001 Volume 40 Issue 2 Pages
204-210
Published: March 22, 2001
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Objective: The effectiveness and efficacy of a primary screening mode (PS) in automatic cytological diagnosis screening supporting AutoPap (AP) were investigated using conventionally prepared Papanicolaou staining slides of cervical-vaginal cytological smear compare estimates by cytotechnologists (CT) to analyze the reliability and problem as PS mode.
Study Design: We studied 3, 410 routine daily slides at areview rate (RR) of 75%, double-ceucleing 175 positive andsuspicious slides (89.7%) at RR 75% and 50%, which we then compared to CT estimation.
Result: Results for 3, 410 slides showed that slides above class IIIa were not observed at RR 75% among those rated “no further review (NFR)”. Results for including positive and suspicious slides showed that class IIIa was observed at RR 75% NFR and color fading was observed. At RR 50%, 5 class IIIa and 2 class IIIb slides were observed, but factors for preparing slides were also observed with only a few abnormal cells or aggregated cells, but no malignancy.
Conclusion: AP in PS mode can be used for conventionally prepared slides at RR 75%. AP in PS mode for slides at RR 50% appears fanorable due to economic efficiency, but requires furthes improvement. AP results were equivalent to those by CT for plane and uniform smear and appropriately wet fixation slides it is admitted that there is the tendency to make use of the function of the AP.
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Kisaburou UENO, Kyoko HASEBE, Shigenori OHTUKA, Kazuhiro YAMAUCHI, Nob ...
2001 Volume 40 Issue 2 Pages
211-215
Published: March 22, 2001
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Objective: Laboratories are constantly required to increase quality control and cut labor. We used AutoPap for quality control in our laboratory since 1998, with excellent results. After the U.S. Food and Drug Administration (FDA) approved AutoPap for primary screening, we wandered whether it would be possible to introduce this automated cytological device for primary screening in Japanese laboratories. We evaluate its economics compared to manual screening.
Study design: Cytological slides were screened by AutoPap system, which sorted them into no further review (NFR), review, and process review (PR) cases. Cytotechnologists rescreened all slides manually.
Results: We studied 24, 796 cases with a 75% review rate (RR), finding 4, 564 NFR (18.4%), 16, 824 review (67.8%) and 3, 408 (13.7%).
Conclusion: Automation cannot yet replace cytotechnologists, but further device improvement should provide cytotechnologists with an invaluable tool in the near future.
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Kiyoshi TAKAMATSU, Hitomi TERUI, Yoshio NAGASHIMA, Miyuki SAITO, Hiroa ...
2001 Volume 40 Issue 2 Pages
216-223
Published: March 22, 2001
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Objective: To assess liquid-based thin-layer sample preparation use in Japan, we studied the efficacy of the ThinPrep Pap Test, compared to conventional Papanicolaou smears.
Study design: Subjects were 1050 patients at the Department of Obstetrics and Gynecology, Keio University Hospital. A conventional Papanicolaou test was conducted with a cotton swab, followed by sample cellection with a broom brush. The brush was rinsed in a fluid preservative from which a ThinPrep slide was prepared using the ThinPrep processor (Cytyc Corporation, USA). Conventional and ThinPrep slides were read independently.
Results: ThinPrep and conventional smear diangoses agreed in 1030 (98.1%) of 1050 cases. Splitsampling, in which the sample is taken from a patient in the usual manner and the collection device smeared across a glass slide, that is then rinsed in a vial, resulted in 98.7%(76 of 77 cases) agreement. We found that ThinPrep provided better classification than the conventional in some cases. Other advantages of the ThinPrep Pap Test include a clean background and uniform cell distribution, time-saving in screening, slides readable using conventional criteria, cells well preserved in a fluid preservative, and easy transport. The greatest advantage is that this method suits new techniques, such as automated screening. Lab run costs and the poor suitability of cotton swabs used widely in Japan proved to be disadvantages.
Conclusion: Liquid-based thin-layer sample preparation is useful and warrants wider use in Japan.
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Hiroshi ARAI, Toshio KARIKOMI, Daigorou JOUMAE, Eio ATARI
2001 Volume 40 Issue 2 Pages
224-225
Published: March 22, 2001
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A 71-year-old woman noticed a solid mass in her right breast and visited our hospital. The mass was diagnosed as apocrine carcinoma and tumor cells contained a large number of 3-37 km intracytoplasmic lumina (ICL) in the cytoplasm. Immunohistochemically, GCDFP-15, EMA, and keratin were positive in tumor cells, but CD 68 was negative.
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Hideyuki KOYAMA, Akinori ISHIHARA, Akira KAMIMORI, Yutaka NAKAMURA, Ta ...
2001 Volume 40 Issue 2 Pages
226-227
Published: March 22, 2001
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We report a case of a 56 year-old woman with stromal sarcoma of the right breast. Macroscopically, the tumor occupied almost of the right breast with crater-like necrosis and hemorrhage. Histologically, spindle tumor cells were closely arranged in a herring-hone pattern. Immunohistochemically, tumor cells were stained with antivimentin. Cytologically, spindle tumor cells showing loosely arranged clusters. Tumor cells consisted of oval or spindle nuclei with a few mitotic figures. These tumor cells had no pleomorphic characteristics. The woman died of respiratory failure and had hypoglycemic attacks in the last few weeks of life.
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