Background: Desmoplastic small cell tumor (DSRCT) is a rare malignancy mainly involv ing the peritoneum of adolescent males. Only a few reports on the cytology of body fluid from patients with DSRCT have been documented. Case: We present the cytological findings for an ascitic fluid sample taken from a 13-year-old Japanese male with intraabdominal DSRCT. The patient was admitted to our hospital for abdominal distention and gross ascites. A cytological evaluation of the ascitic fluid revealled the presence of monotonous small round cells and a small number of another kind of large atypical cells with thick cytoplasm corresponding to the characteristic perinuclear round hyaline material of DSRCT. The tumor was resected, but the patient died from a recurrence two years later. Conclusion: DSRCT should be considered as a differential diagnosis of gross ascites accompanied by a bulky intra-abdominal tumor in adolescents.
We reported a case of malacoplakia of the urinary bladder in which urine cytology was helpful for diagnosis. A 71-year-old woman consulted our hospital for macrohematuria. Urine cytology showed many macrophages containing Michaelis-Gutmann bodies the cytoplasm. Cystoscopy revealed a widely based papillary tumor in the urinary bladder. Histologically, the lesion was granulomatous inflammation consisting of diffusely infiltrated macrophages with Michaelis-Gutmann bodies. The electoron microscopic study demonstrated the myelin-like, small granular structures consistent with Michaelis-Gutmann bodies.
We report a case of squamous cell carcinoma (SCC) in the diverticulum of the urinary bladder. A 73-year-old women reported macroscopic hematuria. Voided urine cytology was negative. Image diagnosis revealed a diverticulum associated with an intradiverticular tumor. Washing cytology of the urinary bladder showed a small number of cyanophilic cancer cells with dispersed chromatin distribution. Initial diagnosis was transitinal cell carcinoma. Retrospectively, however, a few orangeophilic cancer cells consistent with SCC were also found. The resected diverticulum showed a polypoid tumor that was a histologically pure form of keratinizing SCC involving the myometrium (NIT pT 2). SCC accounts for about 20% of all neoplasia from the diverticulum of urinary bladder, and urine cytology is positive in most cases.
In case of tuberculous uterine cervicitis, the presence of epithelioid cells arranged in clusters mixed with Langhans' giant cells in uterine cervical smears was highly suggestive of tuberculosis. The diagnosis was confirmed by the detection of acid-fast bacilli in cultures from the uterine cervix.
We report a case of lung adenocarcinoma with sarcomatous component. A 68-year-old man with a lung tumor in 1999 had undergore left nephrectomy for renal cell carcinoma confined to the kidney in 1996. Cytological examination of bronchial brushing material revealed adenocarcinoma cells. Sarcomatous cells were found in the pleural effusion. Histology of the lung tumor resected by right lower lobectomy was mucinous bronchiolo-alveolar carcinoma with a sarcomatous component. Immunohistochemically, the sarcomatous component was positive for epithelial markers such as keratin and EMA, suggesting that it derived from an epithelial component.
We report a case of Burkitt's lymphoma infiltrating into pleural and peritoneal effusion. A 20-year-old man admitted to Showa University Fujigaoka Hospital in July 1998 reported abdominal colic. Ultrasonography and computed tomography (CT) were used to image the thickness of the small intestine and pleural and peritoneal effusion. Cytological examination of pleural effusion and ascites showed many neoplastic lymphoid cells with a high N/C ratio. Cytoplasms were basophilic and had small vacuoles stained by oil red 0. A chromosome spread showed the characteristic translocation of t (8; 14)(q24; q32). Based on these cytological findings, we diagnosed this case as Burkitt's lymphoma.
We report a case of Merkel cell carcinoma of the right thigh. A 76-year-old man had a tumor of the right thigh about 6 cm in diameter consisting of small round cells diagnosed as Merkel cell carcinoma based on histological, immunohistochemical and electron microscopy examination. Fine-needle aspiration cytology showed small round cells with solid, trabecular, and rosette-like arrangements. Tumor cells had button-like globules in the cytoplasm that were positive for cytokeratin 20, chromogranin A, and neurofilaments.