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Volume 40, Issue 6
Displaying 1-21 of 21 articles from this issue
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Noriyuki FURUTA, Yukitoshi SATOH, Masafumi TUZUKU, Hiroaki KANDA, Yuic ...2001 Volume 40 Issue 6 Pages 565-570
Published: November 22, 2001
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSObjective: Lipoma-like well-differentiated liposarcomas (LT-WDL), which should be distinguished from lipoma, consists of mature fat cells and atypical lipoblasts. To determine the utility of squash cytology in diagnosing lipoma and LT-WDL, we morphologically analyzed cytology and histology specimens from both tumor types.
Study design: Five LT-WDL and 10 lipoma control cases were evaluated retrospectively, analyzing the nuclear size of mature fat cells, the number of atypical lipoblasts, and the number of cells in the cytology and histology specimens.
Results: Mature fat cells in LT-WDL were significantly smaller than those in lipoma (P<0.001). No difference was seen in the number of atypical lipoblasts in cytology and histology specimens.
Since a larger number of tumor cells was seen in cytology histology slides, we observed many cytological features morophologically.
Conclusion: Squash cytology is useful in distinguishing LT-WDL and lipoma compared to histology.View full abstractDownload PDF (4219K) -
focus on differential diagnosis of hepatocellular carcinomaTaku KATO, Youko TSUKUMO, Hisao TAKAHASHI, Miyuki TOKUIZUMI, Tomoko SU ...2001 Volume 40 Issue 6 Pages 571-574
Published: November 22, 2001
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSObjective: We evaluated the usefulness of the CD 34 antibody in cytological diagnosis of hepatocellular carcinoma (HCC) and benign hepatocytic lesions.
Study design: We studied 38 scrape cytological specimens of liver disease, consisting of chronic hepatitis (4), liver cirrhosis (5), focal nodular hyperplasia (2), HCC (6 well diff., 7 moderately diff., 10 poorly diff., 4 undiff.). Specimens were examined uing ABC immunocytochemistry.
Results: All HCC cases were positive for the CD 34 antibody in sinusoidal endothelial cells of tumor nests (100%: 27/27). Fine sinusoidal capillary vessels were positive for CD 34 in well diff. HCC, while thick or and peripheral vessels were positive in moderately diff., poorly diff. and undiff.
Conclusion: We believe that the CD 34 antibody is useful in differential diagnosis of HCC from other liver diseases and the degree of HCC differentiation.View full abstractDownload PDF (3097K) -
Hirohito SUZUKI, Shu ICHIHARA, Masako KASAMI, Fumiyosi SUGIURA, Kazuhi ...2001 Volume 40 Issue 6 Pages 575-582
Published: November 22, 2001
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSObjective: The indeterminate diagnosis or “gray zone” between definitive malignancy and benign breast cytology is further classified into C 3 (atypia probably benign) and C 4 (suspected malignancy) in mammography screening guidelines used in Europe.
Study Design: To clarify the usefulness of such classifications, we reviewed cytlogical specimens from 77 cases with inconclusive cytological diagnosis and definitive histopatholoigcal diagnosis seen at our breast unit in 1992-2000.
Results: Of these, 20 cases (26.0%) were of C 3 (atypia probably benign) and 57 (74.0%) C 4 (suspected malinancy).
Histopathologically, C 3 contained 17 benign lesions (4 papillomas, 4 fibroadenomas, and 9 others) and 3 malignant lesions (3 invasive carcinomas); C 4 contained 2 benign lesions (fat necrosis and papilloma) and 55 malignant lesions (43 invasive carcinomas, 9 noninvasive carcinomas, 2 malignant lymphomas, and 1 phyllodes tumor). Integrating cytology and clinical imaging categories improved the quality of cytological diagnosis by reducing “gray zone” diagnosis that could lead to over-or underevaluation.
Conclusion: The 5 categories (C 1-C 5) in breast cytology reports in Europe are more informative than the 4 conventional insufficient, benign, indeterminate, and malignant categories.View full abstractDownload PDF (5401K) -
Yasushi NOMOTO, Komei KINOSHITA, Toshitaka UEHARA, Taku KATO, Hisao TA ...2001 Volume 40 Issue 6 Pages 583-588
Published: November 22, 2001
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Primary diffuse large-cell lymphoma of the mediastinum is very rare. We report a resected case of Bcell lymphoma.
Case: A 20-year-old woman admitted due to an abnormal shadow in a chest X-ray was found in chest computed tomography (CT) to have a 10×13cm anterior mediastinal mass. Preoperative percutaneous fine needle aspiration cytology (PCNC) showed many atypical cell clusters. Suspecting thymoma, we conducted surgery. Touch smear cytology of the tumor showed large atypical lymphocyte-like cells, and we diagnosed malignant lymphoma. Microscopically, the tumor consisted of large atypical lymphocytic cells with fibrosis. Immunohistochemically, cells stained positively for LCA, L-26, and MB-1. The tumor was diagnosed pathologically as diffuse large B-cell lymphoma, subtype, mediastinal (thymic) large B-cell lymphoma.
Conclusion: Though it was visible to epithelial malignancy with fibrosis, we believe malignant lymphoma can be diagnosed because a few single large cells surrounded cell clusters diagnosed as atypical lymphocytes.View full abstractDownload PDF (8809K) -
Akemi TAKAMIZAWA, Kenji KAWAGUCHI, Jun KANEMOTO, Kyoichi MIYAGAWA, Emi ...2001 Volume 40 Issue 6 Pages 589-593
Published: November 22, 2001
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Muconodular adenocarcinoma characterized by abundant intraglandular mucin and small amounts of cancer cells embedded in pools of mucin is classified in the Japan Lung Cancer Society but not in WHO classification. Because case reports are extremely rare even in Japan, clinicopathologic characteristics are unknown.
Case: A 70-year-old woman admitted to evaluate an abnormal mass in the left upper lung was found in computed tomography (CT) to have inflammatory process or bronchioloalveolar carcinoma. Brushing cytology represented fl at sheets of uniform cells showing mildly atypical oval nuclei with nuclear grooving or cytoplasmic inclusion, suggestive of highly well-differentiated adenocarcinoma. Judging from the gross appearance in video-associated thoracoscopy, we conducted left upper lobectomy and resected the lymph nodes. Histological findings showed a unique muconodular adenocarcinoma with a trilaminar pattern: 1) well-differentiated tubular adenocarcinoma; 2) mucinous bronchioloalveolar adenocarcinoma; and 3) acellular pools of mucin in the alveolar space. We diagnosed muconodular adenocarcinoma.
Conclusion: We present a unique case of muconodular adenocarcinoma of the lung with the following clinicopathologic features: 1) a trilaminar structure; a) well-differentiated tubular adenocarcinoma; b) mucinous bronchioloalveolar carcinoma; c) pools of abundant mucin; 2) sheets or clusters of tumor cells with low-grade nuclear atypia in a mucous background; 3) a possibly favorable prognosis.View full abstractDownload PDF (7029K) -
Hirofumi SAKAMOTO, Yoshio MORI, Naoki YOSHIMI, Yoshimi MIZUNO, Kazuo H ...2001 Volume 40 Issue 6 Pages 594-597
Published: November 22, 2001
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: We present a case of meibomian carcinoma in whom metastatic tumor cells were found in the pleural fl uid and sputum 4 months after the tumor was resected. Few reports describe the cytologic features of meibomian carcinoma cells in the pleural fluid and sputum.
Case: A 77-year-old Japanese woman had a 12×7-mm tumor of the left lower eyelid resected in January 1999. It was diagnosed histologically as a meibomian carcinoma without metastasis. In May 1999, pleural fluid and sputum cytology showed atypical cells with large nuclei and vacuolated or foamy cytoplasm. Oil red 0 staining clearly demonstrated intracytoplasmic lipid droplets. Cytologic fi ndings of these atypical cells were similar to those of the resected primary tumor.
Conclusion: We found metastatic tumor cells in the pleural fluid and sputum of a patient treated for meibomian carcinoma. Lipid-containg vacuoles in tumor cell cytoplasm is an important cytologic feature of this carcinoma.View full abstractDownload PDF (5997K) -
Nobuyuki INOUE, Kousei KINOSHITA, Eriko OIZUMI, Toshiharu MAEDA, Keizo ...2001 Volume 40 Issue 6 Pages 598-600
Published: November 22, 2001
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: We report a case of matrix-producing breast carcinoma.
Case: A 77-year-old woman with a palpable 1.5cm mass in the right breast was suspected in aspiration cytology of having mucinous carcinoma. The tumor had an overt carcinoma element with direct transition to a cartilaginous stromal matrix without intervening spindle cells or osteoclastic giant cells. Immunohistochemical staining showed tumor cells to be positive for S-100 protein and AE 1/AE 3. The final diagnosis was matrix-producing breast carcinoma.
Conclusion: A cartilaginous matrix in mammary aspiration cytology may suggest matrix-producing breast carcinoma.View full abstractDownload PDF (3759K) -
Hideaki NISHIDA, Tetsuo HASHIMOTO, Kazutaka IKEDA, Takuji TANAKA, Shog ...2001 Volume 40 Issue 6 Pages 601-605
Published: November 22, 2001
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: We report cytological findings of a rare case of Merkel cell carcinoma, also called skin neuroendocrine cell carcinoma.
Case: A 86-year-old Japanese woman with a tumor in the left ear underwent resection of the ear containing the tumor and was diagnosed as Merkel cell carcinoma by frozen section. Sheets or small clusters of tumor cells were found in imprint cytology during surgery. Clusters of tumor cells showed a trabecular pattern in crescents. In some areas, intermediate filament buttons were also observed. Most tumor cells were relatively uniform in size with scanty cytoplasm. Their round nuclei with small nucleoli had increased fi ne chromatin.
Conclusion: Characteristic cytological features of tumor cells in combination with clinical findings enabled us to accurately cytodiagnose Merkel cell carcinoma.View full abstractDownload PDF (8899K) -
Tatsuhiko KAWASAKI, Kazuma ONOUE, Yoshirou KIDERA, Hirosi HARADA, Yasu ...2001 Volume 40 Issue 6 Pages 606-609
Published: November 22, 2001
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Angiomyolipoma is histologically characterized by a combination of thick-walled blood vessels, smooth muscle and adipoid tissue. It is sometimes intermingled by atypical large cells difficult to distinguish from malignancy.
Case: A 48-year-old man was referred to our hospital with a right renal tumor found in a multiphasic health screening. The tumor, left untreated for several years, grew slowly. Ultrasonography suggested an angiomyolipoma of the right kidney. Imprint cytology sampled in intraoperative rapid diagnosis showed round or ovoid neoplastic cells with a fine granular chromatin pattern and scant cytoplasm intermingled with atypical large cells, mature lipocytes including small round nuclear and intracytoplasmic vacuoles, and spindle-shaped smooth muscle cells in a fascicular arrangement. No vascular component was identified.
Conclusion: Angiomyolipoma is geperally predicted by recognizing 2 cell forms, but the most important thing to remember is that this noplasm could include atypical large cells mimicking malignancy. A comprehensive evaluation is thus required to rule out malignancy, even if this is extremely rare.View full abstractDownload PDF (4010K) -
Chieko KIYA, Kunihiko WAKAKI, Chizuko MUROSAKA, Shin ISHIZAWA2001 Volume 40 Issue 6 Pages 610-615
Published: November 22, 2001
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Clear cell carcinoma of the urinary bladder is extremely rare. We report cytological findings in an atypical case.
Case: A 59-year old woman reported pollakiuria, macroscopic hematuria, and urinary obstruction. The biopsied specimen histologically indicated transitional cell carcinoma, G 3. Despite chemotherapy, the tumor did not shrink, so she was sent to our hospital. We found a fist-sized tumor on the posterior to anterior wall of the urinary bladder. Urinary cytology showed numerous atypical tumor cells with abundant clear or light green cytoplasm, eccentric nuclei, finely granulated chromatins, and small nucleoli. There were small vacuoles with light green globules in cytoplasm, and distinctive cytoplasmic rims. Multinucleated giant cells were also seen. Histologically, we diagnosed anaplastic tumor cells with multinucleated giant cells, well-differentiated adenocarcinoma of clear cells, and a hobnail pattern. Immunohistochemically, tumor cells were strongly positive for AE1/AE3, CAM 5.2, CK 7, EMA, and Leu M 1, and partially positive for S-100 protein, B 72.3, and PAP. Vimentin was positive in the anaplastic portion.
Conclusion: In differential diagnosis, immunohistological and electronmicroscopical findings should be studied in addition to characteristic cytological features.View full abstractDownload PDF (10887K) -
A case reportYoko ISHII, Kunihiko WAKAKI, Shin ISHIZAWA, Chieko KIYA, Katsuhiko SAI ...2001 Volume 40 Issue 6 Pages 616-621
Published: November 22, 2001
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Goblet cell carcinoid, a rare tumor mainly observed in the appendix, must be differentiated from typical carcinoid tumors because of the aggressiveness. We report characteristic cytological features important for diagnosis, together with other morphological findings, in a case of rectal goblet cell carcinoid.
Case: A 71-year-old man undergoing a Miles operation for a rectal tumor was found, in imprint cytology to have medinm-sized round to oval cells in a solid sheet with rosette formation. Tumor cells had eccentric, round nuclei with low-grade atypia. Chromatin was finely granular and nuclear features were comparable to those of typical carcinoid. The cytoplasm was reticular, and stained light green with accumulated mucin was detected. Tissue section showed 2 different cellular components of classic carcinoid and signet ring cells. Immunohistochemically, tumor cells were positive for neural differentiation markers, cytokeratin (AE 1/AE 3), Muc 1, and Muc 2. Dense-core neurosecretory granules and mucin vesicles coexistent in tumor cells both in double staining and electron-microscopy.
Conclusion: In addition to typical carcinoid-like nuclear features, mucin accumulation in the cytoplasm is important in cytologically diagnosing goblet cell carcinoid.View full abstractDownload PDF (6994K) -
Kouichi TONOOKA, Noriko KATO, Yuuichi YASAKU, Yasushi ENDO, Shinya OGA ...2001 Volume 40 Issue 6 Pages 622-625
Published: November 22, 2001
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Thyrolipoma is a rare thyroid neoplasm containing mature adipose tissue. Few reports concern its cytology.
Case: A 52 year-old-woman with a tumor in the right thyroid lobe was found in aspiration cytology to have tumor cells with fine granular, abundant cytoplasm in small clusters or sheets. Numerous vacuoles larger than these tumor cells were found next to or apart from them. At this point, they were overlooked as artifacts. Under a working diagnosis of follicular adenoma, we conducted right hemithyroidectomy. Histologically, the tumor consisted of follicular cells with oxyphilic cytoplasm and mature fat cells. Reassessed cytology specimens showed that almost all vacuoles overlooked as artifacts were mature fat cells.
Conclusion: Enough fat cells to lead a correct estimation of the histology were obtained in aspiration cytology of a thyrolipoma. Conducting joint Pap and Giemsa staining is thus useful in identifying fat cells.View full abstractDownload PDF (6017K) -
Naomi NASU, Takashi KITAMURA, Atsuko MASUNAGA, Genshu TATE, Toshiyuki ...2001 Volume 40 Issue 6 Pages 626-631
Published: November 22, 2001
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: We report cases of breast tubular carcinoma finally confirmed by histopathological diagnosis. We discuss cytological features of breast tubular carcinoma observed by aspiration cytology from resected specimens.
Case: Patients aged 41 to 48 years were seen for breast tumor. The histological tumor size in all cases was less than 10mm. Cytological features were a few naked spindleshaped nuclei in the background. Cancer cells lack the biphasic pattern of epithelial and myoepithelial cells and consist of tightly adhesive epithelial cells alone. Cancer cells with high cellularity show tubular or sheet-like growth and mild atypia. Typical cytological features were small, slender tubular architectures with obvious lumens, and layers of tubules consisting of approximately 3 cells.
Edges of tubules are sharp and most peripheral cells of clusters showed nuclear peripheral palisading.
Conclusion: Since cytological atypia of breast tubular carcinoma is mild, it is important in cytological diagnosis to determine that cancer cells lack myoepithelial cells and biphasic patterns and have the following additional structurally atypical features: 1) cancer clusters with high cellularity, 2) small tubules and with sharp edges, and 3) nuclear peripheral palisading.View full abstractDownload PDF (8933K) -
Hiroshi FUSHIKI, Hiroyoshi YUKI, Shintarou TERAHATA, Takeshi TASHO, Yu ...2001 Volume 40 Issue 6 Pages 632-635
Published: November 22, 2001
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: A clinical situation occasionally occurs in which diffuse metastatic disease of the peritoneal cavity is noted but the ovaries are of normal size, with or without fine granularity on their external surface. This clinical phenomenon is termed normal-sized ovary carcinoma syndrome.
Case: A 64-year-old woman showed abnormal cells in an aspiration peritoneal Papanicolaou smear from a massive amount of ascites with left breast cancer. Nuclei showed anisonucleosis with marked nucleoli. Microscopic examination showed serous adenocarcinoma indistinguishable from the ovary. She was treated by simple hysterectomy, pelvic lymphadenectomy, and paraaortic lymphadenectomy after neoadjuvant chemotherapy (cisplatin+cyclophosphamide) and postoperative chemotherapy.
Conclusion: We report a patient with a massive amount of ascites and left breast cancer.View full abstractDownload PDF (6020K) -
Seiko OGURA, Keiko SHIMIZU, Hachiro KOBAYASHI, Shinya TOYOKUNI, Masami ...2001 Volume 40 Issue 6 Pages 636-640
Published: November 22, 2001
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: The incidence of multiple primary cancers of the female genital tract is increaseing, but these are difficult to correctly diagnose by cytological smear. We report a case of heterochronous double cancer consisting of adenocarcinoma in situ of the uterine cervix and mucinous cystic tumor with borderline malignancy of the ovary.
Case: A 55-year-old woman with a ruptured right ovarian tumor had right salping000phorectomy 3 years earlier. The histological diagnosis of her ovarian tumor was mucinous cystic tumor with borderline malignancy. Atypical glandular cells were later found in a uterine cervical smear, but no abnormal findings were seen in clinical examination. Total hysterectomy combined with left salpingooophorectomy was done. The histological examination proved to be adenocarcinoma in situ of the uterine cervix. No malignancy was found in the uterine corpus or left adnexa.
Conclusion: Multiple malignancies of the female genital tract should be made combining cytology, clinical data, and diagnostic imaging.View full abstractDownload PDF (6958K) -
Unclassified typeKimihiro NAGAI, Yuji ARAI, Kousuke MARUTSUKA, Noriyuki YAMAUCHI, Masat ...2001 Volume 40 Issue 6 Pages 641-645
Published: November 22, 2001
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Unclassifed ovarian steroid cell tumor is rare. We report its cytological, pathological, and endocrinological findings.
Case: A 19-year-old woman with a pelvic tumor and a high concentration of total serum testosterone had been amenorrheic for 2 years. Physical examination revealed obesity (95 kg, body mass index: 40.06) with obvious increasing facial and truncal hair and acne. Pelvic examination noted an enlarged clitoris. Total serum testosterone was 328 ng/ml (normal: 10-60), and androstenedione was 12 ng/ml (0.6-5.0). Magnetic resonance imaging (MRI) of the pelvis identified the left ovarian tumor, so we conducted left salpingo-oophorectomy. The imprint smear showed a monotonous pattern of scattered tumor cells and clumps accompanied by vessels. Histologically, cells were arranged in diffuse columns or nests, and demonstrated abundant pale cytoplasm without crystals of Reinke, intermingled with rather small cells with granular, eosinophilic cytoplasm. Lipid staining slowed lipid-rich tumor cells.
Conclusion: Unclassified steroid cell tumor is difficult to differentiate from other ovarian tumors in cytological specimens, but clinical findings and imprint specimen pattern of are indicative of unclassified steroid cell tumor.View full abstractDownload PDF (6580K) -
Motohiko SHIMIZU, Toshihiko TOKI, Kiyoshi KATO, Ikuo KONISHI, Mieko HO ...2001 Volume 40 Issue 6 Pages 646-649
Published: November 22, 2001
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Detection of adenocarcinoma cells with squamous cells in endometrial cytology is generally suggestive of primary endometrial carcinoma. We describe a case of primary tubal adenocarcinoma in which adenocarcinoma cells and mature squamous cells were observed in endometrial cytology.
Case: A 67-year-old woman with atypical genital bleeding was found in cervical and endometrial cytology to have clusters of adenocarcinoma cells and isolated small mature squamous cells. Squamous cells were anuclear or had condensed nuclei, and were compatible with dyskeratotic cells. Adenocarcinoma and squamous cells were often intermingled. We conducted a total hysterectomy and bilateral salpingooophorectomy. A small tumor was found within the left fallopian tube, but the endometrium was intact. Histologically, adenocarcinoma resembling tubal epithelium infiltrated papillary, tubular, or solid structures. A squamous component showing marked keratinization was associated with adenocarcinoma. The diagnosis was moderately welldifferentiated serous adenocarcinoma with a squamous component.
Conclusion: Detection of adenocarcinoma cells with squamous cells is not always suggestive of primary endometrial endometrial carcinoma, and extrauterine malignancy should be considered in such a case.View full abstractDownload PDF (3377K) -
Akiko FUJIHARA, Ai UEKUNI, Miyuki MINOOKA, Tatsuya NAKAGAWA, Yutaka DA ...2001 Volume 40 Issue 6 Pages 650-651
Published: November 22, 2001
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe report a case of solitary fibrous tumor (SFT) of the pleura with special reference to stamp and scratch cytology. A 49-year-old man showed a shadow on chest X-ray film. The cytologic appearance was variable, showing dimorphic tumor cells, monolayered cell clusters, isolated cells, collagen bands, and inflammatory cells such as foamy histiocytes and lymphocytes. Tumor cells are reactive for both CD-34 & vimentin, and negative for cytokeratins.View full abstractDownload PDF (3791K) -
Hideko KIGUCHI, Shigeki YAMADA, Masahiro OTA, Yuri AKISHIMA, Yasuko UR ...2001 Volume 40 Issue 6 Pages 652-653
Published: November 22, 2001
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe report a case of pleomorphic adenoma with cystic squamous differentiation of the parotid gland. Needle aspirates of the tumor showed numerous squamous cells without a mucous background. Cuboidal epithelial cells and stromal cells were few. Histopathologically, cystic change in the pleomorphic adenoma formed a large central space lined with stratified differentiated squamous epithelia. Incorrect diagnosis is prevented by paying sufficient attention to determining benign squamous differentiation in pleomorphic adenoma.View full abstractDownload PDF (5243K) -
Masako OTANI, Shiro TSUJIMOTO, Myota MIURA, Yoji NAGASHIMA2001 Volume 40 Issue 6 Pages 654-655
Published: November 22, 2001
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSA 6 year-old boy was diagnosed with infected renal cysts that were removed in pieces. Cytological examination of purulent fluid from the cysts during surgery contained a few isolated keratinizing aquamous cells and hair shafts with inflammatory background. Intrarenal cystic teratoma is very rare. Differential diagnosis of intrarenal cysts is paramount, especially in children, to ensure the correct choice of therapy. In our case, we found cytologic examination duning surgery to be useful in dianosis.View full abstractDownload PDF (4910K) -
Yasuhiko ENDO, Isoko ARASAKI, Tamayo MISUMI, Jun NEMOTO, Ritsuko EMA2001 Volume 40 Issue 6 Pages 656-657
Published: November 22, 2001
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe report a case of nasal polyps with stromal atypical cells in a 5-year-old boy, whose cytologic features simulated rhabdomyosarcoma. A polypoid lesion of the left nasal cavity grew rapidly and showed a necrotic, hemorrhagic surface. Aspiration cytology showed spindle to polygonal cells with 1 or 2 oval nuclei in the necrotic and hemorrhagic background. Conspicuous nucleolei were observed in these cells. Cytologically, possible embryonal rhabdomyosarcoma was initially suspected. However, histology disclosed a few atypical cells without mitosis scattered in edematous stroma, and finally was interpreted as nasal polyps with stromal atypia. It was suggested that the number of atypical cells, low mitotic rate, and absence of intracytoplasmic glycogen in atypical cells are important in cytologically differentiating this from rhabdomyosarcoma.View full abstractDownload PDF (4329K)
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