We report a case of sebaceous carcinoma of the left upper eyelid in a 57-year-old man. Imprint cytology of the tumor revealed large and small clusters composed of large and atypical cells with a high N/C ratio, small and hyperchromatic nucleoli, and well-demarcated small vacuoles in cystoplasm. Histologically, the tumor consisted of irregularly lobules of different sizes. Each lobule consisted of cells exhibiting cytoplasmic vacuolation. Sudan III and sudan black demonstrated the presence of fat within tumor cells.
Pleomorphic xanthoastrocytoma (PXA) is a benign tumor in the cerebrum of youth whos pathological findings show plemorphism resembling glioblastoma (GB). We present a case of cerebral PXA in a 16-year-old woman demonstrating the usefulness of rapid intraoperative cytology. Cytologically. tumor cells revealed marked pleomorphism with cytoplasmic processes. Vacuolated cells also intermingled among tumor cells. Mitotic figures. necrotic debris, endothelial swelling, and glomeruloid appearance seen in GB were absent. The cytological approach used in addition to histology using frozen section was useful for rapid intraoperative diagnosis, including diagnosis differentiating PXA and GB.
We report cytologic features of a pure form of invasive micropapillary carcinoma (IMPC) of the breast in a 66-year-old woman. Aspiration cytology of IMPC from resected specimens showed numerous cohesive clusters with an inverted growth pattern and microvilli at the periphery. The lesion resembled a group of islands. Because IMPC has a high potential for lymphatic vessel invasion an awareness of possible IMPC and definite diagnosis before mastectomy are important in disease management.
An 83-year-old woman with vaginal bleeding was found to have a nodule in the vaginal wall but no hypergammaglobulincmia or dysfunction of other organs. Smear cytology showed clusters of giant cells without atypia, and localization of globular amorphous material within cytoplasm. histological examination confirmed an amyloid tumor with a prominent foreign-body giant cell reaction. Since foreign body reaction often characterizes localized amyloidosis and amyloid material itself is difficult to identify in routine staining, multinucleated giant cells serve as a diagnostic clue for diagnosing of localized amyloidosis.
We report the case of a 72-year-old woman with extraovarian serous lary carcinoma (ESSPC). Endometrial cytology showed small numbers o malignant cells with iotracytoplasmic vacuoles. The cytol-ogy smea was not necritic. Physical and imaging of the pelvic cavity showed ormality. Pathological examination of the surgical specimen showed arcinoma infiltrating the surface of the normal sized ovary and sprht the peritoneal surface. The presence of small, clusters of malig thout necrotic background should indicated to need to consider a po terine malignant disease including ESSPC.