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Volume 41, Issue 4
Displaying 1-15 of 15 articles from this issue
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Yoshihiro IMAEDA, Yoshimune HORIBE, Yuuzi NASU, Yoshinori SUZUKI, Kazu ...2002 Volume 41 Issue 4 Pages 245-250
Published: July 22, 2002
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSObjective: Acinic cell carcinoma (ACC) of the salivary gland is difficult to diagnose cytologically because it shows variable morphology, resembles normal acinic cells, and seldom contains atypical cells.
Study Design: We studied the architecture of ACC cell clusters and tumor cells, and compared its cytological features with histopathological findings.
Results: Cytomorphologically, cell clusters were classified as acinar, rosette-like, ductal, pseudopapillary, and adhering to capillary blood vessels. Histologically, all tumors were diagnosed as solid ACC, but some tumor cells formed glandular lumina. At the cyst sites, tumor cells showed papillary proliferation in the lumina. Immunohistochemically, amylase staining was positive, and CD34 staining highlighted numerous capillary vessels. Ki-67 staining was positive in less than 5% of primary tumors and 10% of recurrent tumors.
Conclusion: Observation of the 5 types of tumor cell clusters we examined is of great help in diagnosing ACC. In cytologic examination, it is important to assess tumor cell appearance, cell cluster structure, and features of cells composing clusters rather than individual cell characteristics.View full abstractDownload PDF (10201K) -
A double-immunohistochemical study for keratin and alpha-smooth muscle actinKen-ichi OHTA, Midori KIKUCHI, Shojiroh MORINAGA, Toshikatsu KOHRI, To ...2002 Volume 41 Issue 4 Pages 251-259
Published: July 22, 2002
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSObjective: We clarified the typical cytological features and diversity of epithelial-myoepithelial carcinoma of the salivary gland.
Study Design: We compared preoperative fine-needle aspiration cytology and histological specimens from 4 cases of epithelial-myoepithelial carcinoma, conducting double immunostaining for keratin (KL-1) and alpha-smooth muscle actin (SMA). We also conducted immunohistochemical studies using epithelial and myoepithelial markers.
Results: Epithelial cell clusters having dispersed cells with naked nuclei in the background were characteristic of typical cellular tumors without basement membrane thickening. Mucous globules reminiscent of adenoid cystic carcinoma were rarely seen. SMA clearly marked myoepithelial components at the periphery of cell clusters and background in cytological specimens, as did KL-1 for epithelial components at the center of cell clusters.
Conclusion: Although cytological tumor features were typical, cytology alone would be insufficient for a definitive diagnosis. Double immunostaining was useful in distinguishing epithelial and myoepithelial components in cytological specimens.View full abstractDownload PDF (15855K) -
Takihiro KAMIO, Shuji SUKO, Hidemitsu OHKADO, Kazuhiko HIROTA, Shuji T ...2002 Volume 41 Issue 4 Pages 260-264
Published: July 22, 2002
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Mixed neuroendocrine-neural tumor (MNNT) is a rare type combining pheochromocytoma and a group of neuroblastomas. We report a case of MNNT of pheochromocytoma and ganglioneuroblastoma arising in the adrenal gland.
Case: A 43-year-old woman with epigastralgia was found in abdominal ultrasonography (us) to have an adrenal tumor diagnosed as pheochromocytoma and surgically resected. Grossly, the tumor formed a cyst whose wall was covered by dark red areas and yellowish-white thickened areas. Imprint smears and histological specimens from the 2 color areas showed, polygonal cells singly or in sheet clusters in the dark red areas, histologically diagnosed as pheochromocytoma. Ganglion cell-like giant cells and spindle cells were observed in the yellowish-white areas. Histologically, ganglion cell-like giant cells and neurofilaments proliferated in this area, leading to a diagnosis of ganglioneuroblastoma.
Conclusion: In imprint cytology from an adrenal tumor suspected of being pheochromocytoma, we must carefully examine the cut tumor surface and take specimens from different areas. If pheochromocytoma is present in cytology, we should consider a neuroblastoma component.View full abstractDownload PDF (6355K) -
Kouichi NAGAYA, Naoko NISHIZAWA, Hiroko TAKAMURA, Kuniko NAKA, Atsuko ...2002 Volume 41 Issue 4 Pages 265-269
Published: July 22, 2002
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Pancreatic osteoclastoid giant cell carcinoma (OGCC) is a rare primary tumor of the pancreas characterized by osteoclast-like giant cells. OGCC must be distinguished from classic giant cell carcinoma because OGCC has a better prognosis. We report a case of OGCC detected by endoscopic brushing cytology.
Case: A 67-year-old woman reporting a month of epigastralgia was found in. X-ray computed tomography (CT) to have a pancreatic mass. Brushing cytology of the pancreatic duct under endoscopy demonstrated 2 cell populations:(1) large to intermediate polygonal to spindle malignant cells with high nuclear/cytoplasmic ratios, irregular nuclear membranes, and coarse chromatin; and (2) bland, osteoclastic giant cells with multiple uniformly small, round, nuclei and prominent nucleoli. We diagnosed this tumor as OGCC. Histologically, the resected tumor showed OGCC findings. The women has surviced with solitary liver metastasis 4 years and 5 months after surgery.
Conclusion: Cytopathological features of OGCC of the pancreas are fairly specific, and cytology is useful in differentiating OGCC from other giant cell pancreatic lesions, particularly more aggressive pleomorphic carcinoma. Although most reports of OGCC were diagnosed usinbg fine-needle aspiration, endoscopic brushing cytology has proven very useful in our case.View full abstractDownload PDF (6150K) -
Hajime SAKAI, Yuichi MARUTA, Etsuko ISE, Yoshinobu HOSHII, Hiroo KAWAN ...2002 Volume 41 Issue 4 Pages 270-273
Published: July 22, 2002
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Renal pelvic and ureteral lesions are difficult to diagnose because of technical difficulties in obtaining tissue specimens. We reported a case of transitional cell carcinoma in situ (CIS) in the right ureter suspected preoperatively from radiographic and cytological examinations.
Case: A 70-year-old man diagnosed with transitional cell carcinoma (Grade 3) in the urinary bladder in 1989 underwent chemotherapy alone and the tumor decreased in size. Four years later, in 1993, the tumor relapsed in to the urinary bladder, necessithting transurethral tumor resection and spell out (BCG) therapy. A follow-up urinary examination disclosed hematuria on November 1999. Retrograde pyelography showed an irregularity of the right ureteral wall. Atypical transitional cells with increased nuclear chromatin and distinct nucleoli were seen in urinary cytology from the right lower ureter and vesical washing solution, suggesting malignancy. Right ureteronephrectomy was done in February 2000. CIS in the right lower ureter was diagnosed on histological examination.
Conclusion: Cytological examination is useful for evaluating ureteral lesions.View full abstractDownload PDF (5881K) -
Chiaki YAMAGAMI, Masuo ISHIGAMI, Yoshitake HAYASHI2002 Volume 41 Issue 4 Pages 274-277
Published: July 22, 2002
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Ductal adenoma is a benign intraductal neoplasm of the breast, whose clinical and histopathological features are extremely similar to those of breast cancer, malcing them difficult to differentiate. We discuss cytological features leading to a definitive diagnosis.
Case: A 60-years-old woman with an increased palpable left breast tumor was found in imaging to have a 2-cm-diameter cystic tumor including a 1-cm-diameter solid mass. Aspiration cytology, showed sheet-like and partly gland-like clusters consisting of duct-epithelial and myoepithelial cells we interpreted as benign but could not easily cytolgical and imaging features. The diagnosis of ductal adenoma was histologically made based on resected materials.
Conclusion: To prevent overtreatment due to misdiagnosis and to definitively diagnose breast disease, we account for information from cytology, patient age, imaging analysis, and histological features.
It is particularly important to keep ductal adenoma in mind when diagnosing fibroadenoma or mastopathy cytologically despite clinically malignant manifestations.View full abstractDownload PDF (5392K) -
Setsu AKAMATSU, Yukari HIMEJI, Mayumi MATSUDA, Yuuko NAGASAWA, Miyako ...2002 Volume 41 Issue 4 Pages 278-280
Published: July 22, 2002
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: We report invasive micropapillary carcinoma (IMP) detected in a male breast.
Case: An 81-year-old man noticing a small firm mass just below the nipple in August 2001 was found to have a 1cm firm mobile round tumor having a smooth surface. Fine-needle aspiration cytology showed various-sized papillary clusters against a clear background. Nuclei were round and not prominent., Since no stromal cells were seen around clusters, the tumor was suspected of being malignant and resected while its histological type was unknown. Histologically, clusters composed of 10-50 cells were observed in nests and separated by stroma. Large clusters had some clear zones/vacuoles, but neither (fibro? Vacuolation/ cavitation?) nor a prominent nucelus was noted, leading to a diagnosis of IMP.
Conclusions: Fine-needle aspiration cytology is useful in the early diagnosis of IMP.View full abstractDownload PDF (3417K) -
Junko SHIMOSAKO, Mitsuko MATSUO, Hideki NOGUCHI, Masayo KARIYAMA, Yoh ...2002 Volume 41 Issue 4 Pages 281-285
Published: July 22, 2002
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Uterine cervical glassy cell carcinoma (GCC) is a rare gynecologic malignancy. We report cytopathlogical GCC features in 3 cases found in the cytological examination of uterine cancer.
Cases: Women aged 55, 47, and 49 years old, reported atypical genital bleeding and watery genital discharge. Cytopathlogical diagnosis in all cases was suspected class V adenosquamous cell carcinoma, with 1 case strongly indicating GCC. Histopathological examination of biopsy specimens and surgically resected tissue demonstrated glassy cell carcinoma of the uterine cervix, stages II b, Ib1, and I b2.
Conclusion: GCC can be diagnosed by careful observation of cytopathologic specimens because GCC cells have several distinct cytopathological characteristics.View full abstractDownload PDF (6473K) -
Takashi UMEZAWA, Kouichi NOMURA, Yutaka YAMAGUCHI, Setsuko HARUMA, Mak ...2002 Volume 41 Issue 4 Pages 286-290
Published: July 22, 2002
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: We report a rare case of a sex cord-like tumor of the uterine corpus.
Case: A 75-year-old woman was admitted with a complaint of genital bleeding. An endometrial smear specimen revealed atypical cells with rosette-like and trabecular arrangements. The tumor cells had small round nuclei with finely granular chromatin. The cytology specimen suggested small cell carcinoma. Histologically, the tumor was composed predominantly of proliferative cells resembling ovarian sex cord stromal tumor cells and of small areas of low-grade endometrial stromal sarcoma. Structures resembling Call-Exner bodies were observed. An immunohistochemical examination demonstrated that the sex cord-like tumor cells were positive for cytokeratin and vimentin. but negative for inhibin. The tumor was diagnosed as a sex cord-like tumor.
Conclusion: The cytologic features of sex cord-like tumor are rosette-like and trabecular arrangements of atypical cells with small round nuclei and fine. granular chromatin.View full abstractDownload PDF (9314K) -
Yumiko TAKEDA, Keiichi IWAYA, Akinori WATANABE, Toshitaka NAGAO, Tohru ...2002 Volume 41 Issue 4 Pages 291-295
Published: July 22, 2002
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Sex cord tumor with annular tubules (SCTAT) is a rare entity, with only 15 cases reported in Japan. We report such a case, and its cytological and immunohistochemical findings.
Case: A 63-year-old gravida 2, para 2 woman was found to have an intrapelvic mass by ultrasonography on a routine medical examination. She had no signs of Peutz-Jeghers syndrome. A right oophorectomy was performed and the right ovary was occupied by a 9×7×6cm multilocular cystic tumor. Many epithelial clusters in stamp and squashed cytological specimens were obtained from the thickened cystic wall. Epithelial clusters formed tubular and lobular structures. The majority of epithelial cells had clear cytoplasm with PAS-positive granules. A few epithelial cells had cytoplasmic alcianophilic mucin. They were also immunoreactive for CA19-9 and CEA, and were considered to be a heterologous element of intestinal epithelial cells. The majority of epithelial cells was negative for CEA or CA19-9, but positive for AFP.
Conclusion: Since the association of heterologous elements and the expression of AFP are frequently seen in Sertoli-Leydig cell tumor, this case was considered to be related to Sertoli-Leydig cell tumor.View full abstractDownload PDF (3671K) -
Hanae NAKASHIMA, Mieko HORIKAWA, Hiroyoshi OTA, Takayuki HONDA2002 Volume 41 Issue 4 Pages 296-297
Published: July 22, 2002
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSCytological findings of atypical adenomatous hyperplasia (AAH) in a 46-year-old man were compared to histological findings of biopsy specimens via fiberoptic bronchoscopy and videoassisted thoracoscopic surgery (VATS). The 12×10mm tumor, located at left S3, was diagnosed microscopically as AAH. Both the cytological specimen obtained by transbronchial needle aspiration and the histological specimens via transbronchial biopsy by bronchofiberscopy were evaluated. Cytological findings showed single atypical cells, discohesive clusters, and sheet-like arrangements. Round or oval nuclei were centrally located. and nuclear inclusion was often observed. Bi-and multinucleated atypical cells were seen, but not grooving or mitotic figurs, except rarely. These features may be important in distinguishing AAH from adenocarcinoma.View full abstractDownload PDF (5678K) -
Hiroshi NAKAMURA, Tetsuya OKAZAKI, Junichi KOYATSU, Fujihiko SUZUKN, Y ...2002 Volume 41 Issue 4 Pages 298-299
Published: July 22, 2002
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe report 2 cases of urachal carcinoma having totally different cytological features. Tumor cells in case 1 were highly atypical. having scanty mucin in the cytoplasm and growing in papillary patterns. Tumor cells in case 2 showed mild atypia with abundant mucin. Case 1 was difficult to distinguish cytologically from poorly differentiated transitional cell carcinoma. Case 2 was difficult to distinguish from adenoma. A definitive diagnosis of urachal carcinoma having these cytological features can only be made combining characteristic clinical findings.View full abstractDownload PDF (3826K) -
Masayuki NAKANO, Eiichro HIRAKAWA, Kousuke SAOO, Masafumi OHONO, Shoji ...2002 Volume 41 Issue 4 Pages 300-301
Published: July 22, 2002
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe report a case of neuroendocrine carcinoma of the uterine cervix with HPV-18infcction in a 145-year-old wolnan.
The tulllor arose in the uterine cervix. with the tumor surface necrotic and bioody. Cytology showed abundant tumor cell ina Ilecrotic background, with slnall rourld or short spindle nuclei, scant cytoplasnl or strippcd nuclei, scattered individually and aggregated in small clusters, and delicate or coars cgranular cllrolnatin.
Hislologically, small turnor cell swere arranged in nests cell cords and a ribbonpattern.Thistumor wasdiagnosedasby spellout (ISH) a sneuroendocrinecarcillomawitll HPV-18illfectiollarisingintheuterinecervix. We fouu/d cytological examination to be useful in this diagrlosis.View full abstractDownload PDF (3395K) -
Hitoshi ITOH, Youko MIYAJIMA, Yoshiyuki OSAMURA, Yutaka TSUTSUMI2002 Volume 41 Issue 4 Pages 302-303
Published: July 22, 2002
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSCell transfer is required to immunostain multiple antigens on cytology specimens. A variety of resins is used but the conventional sequence usually takes a couple of days to complete transfer. We cueated a quick method by covering the slide glass with a small volume of diluted Malinol in a process that is completed within 1 hour if the cover slip is peeled off the glass slide. Appropriate trimming of the thin solidified'ulalinol membrane into several pieces yields multiple specimens for immunocytochemical reaction, using a single cytological material.View full abstractDownload PDF (2423K) -
[in Japanese]2002 Volume 41 Issue 4 Pages ix-xvi
Published: July 22, 2002
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSDownload PDF (1183K)
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