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Volume 42, Issue 5
Displaying 1-13 of 13 articles from this issue
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Hiroshi NAKAMURA, Kazuhisa ISHI, Takeko FURUKAWA, Tetsuya OKAZAKI, Kat ...2003 Volume 42 Issue 5 Pages 337-341
Published: September 22, 2003
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSObjective: Urinary cytology widely used to screen for urothelial transitional cell tumors, presents problems of low sensitivity and false negative results for tumors with weak cellular atypia. The recently developed urinary tumor marker urinary matrix protein 22 (NMP22), which rapidly confirms early urothelial transitional cell carcinomas, presents a viable screening alternative. We compared urinary NMP22 levels and results of histological diagnosis and cystoscopy to clarify screening for urothelial transitional cell carcinoma.
Materials and Methods: Subjects were 675 cases submitted by the Department of Urology for urinary cytology and NMP22 levels (Konica Matritech UMP22 test kit, ELISA) examinations between July 2000 and April 2002.
Results: We diagnosed 31 cases of carcinoma (G1: 8. G2: 19. G3: 4) clinically and histologically of these, NMP22 was positive in 17 and negative in 14, while cytology was positive in 14 cases and negative in 17 cases. Urinary cytology showed no definite false positive (+) cases, but 17 were suspected positive (±). NMP22, yielded 96 false positive cases due to inflammation and calculus in some cases presenting cellular atypia in urinary cytology and high NMP22 levels in samples with high white blood cell components.
Discussion: Urinary cytology is useful for specific malignant tumors, but also involves low detection sensitivity. While NMP22 was superior to urinary cytology in detecting of G1 carcinomas, many false positive results occurred in samples with high white blood cell components such as pyuria. NMP22 and urinary cytology should thus be used in combination because NMP22 and, cytological results differ.View full abstractDownload PDF (3307K) -
a case reportTakashi UMEZAWA, Kouichi NOMURA, Makoto YASUDA, Yutaka YAMAGUCHI, Shig ...2003 Volume 42 Issue 5 Pages 342-346
Published: September 22, 2003
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Variations in terminology for neuroendocrine tumors of the uterine cervix have caused considerable confusion, and prevented cytological carcinoid features from being fully applicable.
Case: A 41-year-old woman admitted after 4 months of abnormal genital bleeding had clusters of small neoplastic cells with a rosette-like or gland-like arrangement and scattered found in a uterine cervix smear specimen, isolated cells. Tumor cells had small uniform nuclei with coarsely granular chromatin, moderate amounts of cytoplasm, and absent nucleoli. The cytology specimen suggested a diagnosis of carcinoid. Histologically, the tumor was diagnosed as small cell carcinoma with a carcinoid element. We interpreted smear specimen cells as being from the carcinoid element.
Conclusion: Cytologic features of carcinoid of the uterine cervix include rosette-like or gland-like arrangements of small neoplastic cells with uniform nuclei, coarsely granular chromatin, and moderate amounts of cytoplasm.View full abstractDownload PDF (8522K) -
A case reportKumiko TAKAHASHI, Yasuyuki NAKAMURA, Tsutomu SAKUMA2003 Volume 42 Issue 5 Pages 347-352
Published: September 22, 2003
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Goblet cell carcinoid tumor of the vermiform appendix, a subtype of carcinoid tumor, comprises cells showing both neuroendocrine and glandular differentiation, including a mucus-producing goblet-cell-like appearance. We detail cytological features of this tumor in view of its extreme rarity in the literature.
Case: A 45-year-old woman with dysuria and abdominal distension due to large amounts of ascites was found on cytological examination of the endometrium and ascites to have signs of malignancy. In the endometrium, a mixture of cells with tumor cells with a goblet-cell-like appearance and those with a high N/C ratio and round to oval nuclei were arranged sheet-like or in slightly overlapping clusters. A few rosette patterns were recognized. Preoperative biopsy of the endometrium already suggesting unique features, together with postoperative histopathology, certified a diagnosis of goblet cell carcinoid tumor arising form the vermiform appendix with metastases to the uterus, both ovaries, and the peritoneum.
Conclusion: We present typical findings for goblet cell carcinoid tumor was presented. The presence of typical features such as tumor clusters comprising goblet cells and a rosette-like arrangement is cytologically different from mucus-producing adenocarcinoma of the uterus, either primary or metastatic.View full abstractDownload PDF (10303K) -
Yoshifumi ASAKURA, Tomoka IMAMURA, Michiho TAKENAKA, Toshie TERAUCHI, ...2003 Volume 42 Issue 5 Pages 353-357
Published: September 22, 2003
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Thymic carcinoma is extremely rare that in thymoma. We report such a case and review cytological findings.
Case: A 20-year-old man was found to have aberrant density in thoracic radiography in a school medical examination. Laboratory tests showed high levels of serum SCC and CYFRA. Fineneedle aspiration cytology and needle biopsy were done and the tumor diagnosed as thymoma. The resected tumor was 12cm in diameter. Fine-needle aspiration cytology of the tumor showed clusters of epithelial cells with numerous lymphocytes. A touch smear of the resected tumor showed more atypical cells with giant nuclei and prominent nucleoli. Two different patterns were seen in the resected tumor: On the lung side of the tumor, epithelial cells had slightly large nuclei accompanied by numerous lymphocytes; On the cardiac side, epithelial cells had larger nuclei with an irregular margin and prominent nucleoli. These findings suggest the diagnosis of undifferentiated thymic carcinoma in thymoma.
Conclusion: The possibility of thymic carcinoma must be considered if cytologic features of a thymic tumor show a large nucleus and atypia suggesting malignancy.View full abstractDownload PDF (5961K) -
Case report with cytopathological featuresTakeshi OKAMOTO, Tatsuo WATANABE, Chie MACHIDA, Yoshiaki KARAKI, Shin- ...2003 Volume 42 Issue 5 Pages 358-361
Published: September 22, 2003
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Matrix-producing carcinoma (MPC) is a rare type of breast carcinoma and a histological variant of metaplastic carcinoma. We report a case of MPC based on cytological and histological findings.
Case: A 64-year-old woman with a palpable mass in the right breast was found in fine-needle aspiration of the mass to have tumor cells with a myxedematous, necrotic background diagnosed as mucinous carcinoma or comedo carcinoma. The operative specimen showed MPC with the myxedematous material in the center area and a cellular arrangement in peripheral areas. Retrospectively, cartilage-like cells in the smear were recognized in a small area against a myxedematous background.
Conclusion: MPC, a rare breast carcinoma, may be determined based on fine-needle aspiration findingical of typical cytological features.View full abstractDownload PDF (6189K) -
[in Japanese], [in Japanese]2003 Volume 42 Issue 5 Pages 362
Published: September 22, 2003
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSDownload PDF (81K) -
Yusuke MATSUURA, Toshinori KAWAGOE, Naoyuki TOKI, Masamichi KASHIMURA2003 Volume 42 Issue 5 Pages 363-370
Published: September 22, 2003
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSObjective: We evaluated the effectiveness of conservative treatment for early cervical neoplasia and the usefulness of cytology.
Study Design: During the 17 years from 1984 to 2000, we conducted cold knife conization on 277 patients with early cervical neoplasia. We followed up 156 patients without definitive treatment and 121 patients treated with hysterectomy following conization.
Results: Abnormal cytology was detected in 15 (11%) of 140 patients treated with therapeutic conization, but 12 of 15 cases had negative cytology at the final visit. Three (2%) of 121 patients with hysterectomy had abnormal vaginal cytology. Cervical cytology immediately after conization showed 24% false positive and 43% false negative. Negative predictive value of endocervical curettage (ECC) and margin status was 63% and 86%. Some 33 pregnancies occurred in 21 patients after conization, with subsequent 16 healthy infants.
Conclusion: Cytological examination immediately after conization is not useful for evaluating the residual lesion, and margin status and ECC are strong predictors of residual disease. Conservative procedures such as conization are fully acceptable in patients who preserve reproductive function, and careful follow-up with cytology after treatment is needed.View full abstractDownload PDF (3145K) -
Takayoshi NOGAWA, Masamichi HIURA, Mayu YUNOKAWA, Keijiroh ITOH, Takaf ...2003 Volume 42 Issue 5 Pages 371-377
Published: September 22, 2003
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSObjective: We evaluated the significance of HPV infection in cytology for predicting the recurrence of cervical intraepitherial neoplasia after conservative treatment.
Study Design: Subject were 554 women treated for dysplasia in 129, CIS in 224, and stage Ia cervical cancer in 201 by hysterectomy, conization, and laser vaporization. Koilocytosis as HPV infection was examined with recurrence after treatment.
Results: Uterus-preservation therapy using laser vaporization or conization was conducted on 94% with dysplasia, 53% with CIS, and 18% with stage Ia cervical cancer. Recurrence was as follows: dysplasia: 4/17 (24%); CIS: 1/7 (14%) in laser vaporization, and dysplasia: 4/104 (4%) and CIS: 3/113 (3%) in conization. Koilocytosis was detected cytologically or histologically in pre-or posttreatment with all recurrences.
Conclusion: Koilocytosis as an HPV infection is a significant predictive factor for the recurrence of cervical intraepitherial neoplasia after conservative treatment.View full abstractDownload PDF (2914K) -
Takashi ODA, Keiichi FUJIWARA, Kenichiro MAEHATA, Hiromasa TANAKA, Ich ...2003 Volume 42 Issue 5 Pages 378-383
Published: September 22, 2003
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSObjective: To evaluate the relationship between loop electronic excision procedure (LEEP) manifestation and outcome of Human-papillomavirus (HPV) positive cervical intraepithelial neoplasia (CIN) patients.
Study Design: We made a retrospective chart review of 341 patients with CIN treated at the Kawasaki Medical School between January 1995 and September 2001. All patients underwent cytological evaluations, punch biopsies under colposcopy, and HPV-DNA tests at the first visit. Patients were either followed-up, or treated by LEEP vaporization, conization or hysterectomy.
Results: HPV positivity was 66%(CIN 1), 83%(CIN 2), and 85%(CIN 3). In 341 patients, 39 cases with hysterectomy and 50 cases with follow up of less than 6 months were excluded from followup analysis. In cases with LEEP manifestations, the normalization rates of cytology were 89%(CIN 1), 93%(CIN 2), and 92%(CIN 3). The eradication of HPV was 68%(CIN 1), 90%(CIN 2), and 78%(CIN 3). These numbers were significantly better than normalization and eradication in patients without treatments.
Conclusion: Our observations indicate that LEEP vaporization or conization may help eradicate in HPV of CIN patients as and the lesions.View full abstractDownload PDF (2822K) -
The association with the prognosis, HPV and telomeraseMasatoshi YOKOYAMA, Koichi HARA, Michiko UCHIYAMA, Mitsuyo NOGUCHI, Ya ...2003 Volume 42 Issue 5 Pages 384-389
Published: September 22, 2003
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSObjective: We evaluated the biological activity of individual HPV types and telomerase activity in cervical carcinogenesis.
Study Design: Cellular samples from 318 patients with cervical intraepithelial neoplasia (CIN) or invasive cervical carcinoma were examined for HPV DNA using the polymerase chain reaction. We followed up 145 women with CIN I and CIN II. Telomerase activity was examined for exfoliated cervical cells from a genital population of 245 women undergoing routine cervical screening by Papanicolaou smear. Those found to have telomerase activity or abnormal cytology in exfoliated cells were examined for cervical lesions by colposcopy and biopsy.
Results: Our classification of HPV types based on HPV prevalence data correlates well with prospective follow-up data. A significantly higher progression was observed in HPV-negative CINs. Telomerase activity was found in 16 exfoliated cell samples (16/245, 6.5%); high-risk HPV DNA was found in 9 of these samples (9/16, 56%); and 9 biopsy specimens evaluated from patients testing positive for telomerse revealed CIN Ilesions (9/11, 82%).
Conclusion: HPV types are classifiable by risk of malignancy developing. HPV-negative lesions are likely to progress to a malignant state. Telomerse activity is often associated with high-risk HPV infection and telomerase assay can help to detect occult cervical lesions.View full abstractDownload PDF (3381K) -
Shigeki ISHIGURO, Hideko KIGUCHI, Takao MURAMATSU, Mayu HOSOE, Masao N ...2003 Volume 42 Issue 5 Pages 390-391
Published: September 22, 2003
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe report metastatic cytological findings in ovarian clear cell adenocarcinoma. A 54-year-old woman diagnosed with ovarian clear cell adenocarcinoma stage HI developed a nodular lesion and hematuria after surgery and chemotherapy. Imprint cytology from the cutaneous tumor showed large nuclei with prominent nucleoli and abundant clear cytoplasm. Urinary cytology showed many clusters including a hobnail pattern. Tumor cells had clear cytoplasm and round nuclei with prominent nucleoli Although cutaneous or urinary cytological findings in clearcell adenocarcinoma are rare. it is important to observe the in cytoplasmic character and cluster patterns.View full abstractDownload PDF (2944K) -
Hiroaki KASE, Takumi KURABAYASHI, Kenichi TANAKA, Etsuko NAGAI2003 Volume 42 Issue 5 Pages 392-393
Published: September 22, 2003
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe report a case of ovarian carcinosarcoma with a heterologous element diagnosed with ascites cytology. A 41-year-old woman was admitted because of huge ascites, the cytological specimen of which showed isolated large cells with irregular nuclei and giant pleomorphic round cells surrounding a mucinous background. Histologically, the ovarian tumor was diagnosedas carcinosarcoma with chondrosarcoma. In this case, we were able to diagnose ovarian earcinosarocnia from the ascites cytology. because of rupture of an ovarian tumor and disseminating of the chondrosarcomaous elements.View full abstractDownload PDF (4578K) -
Takenobu NAKAGAWA, Yasuhiro TERASAKI, Osamu NAKAMURA, Mika YOSHIMATSU, ...2003 Volume 42 Issue 5 Pages 394-395
Published: September 22, 2003
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe report cytological features for an autopsy case of moderately differentiated gastric tubular adenocarcinoma showinghepatoid differentiation in metastatic lesions. At autopsy, imprint cytology of pulmonary metastases showed two different types of malignant cells; one arranged in an acinar pattern, suggesting features of moderately differentiated adenocarcinoma, and the other composed of cancer cells resembling cytological features of hepatocellular carcinoma. An accurate diagnosis ofhepatoid adenocarcinoma is very important because of the miserable prognosis, making the cytological findings from our present case useful in differentiating between hepatoid adenocarcinoma and common types of adenocarcinoma.View full abstractDownload PDF (3033K)
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