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Volume 43, Issue 2
Displaying 1-8 of 8 articles from this issue
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Ritsuko IMAI, Sonoko NATSUME, Masako HASHIMOTO, Rie TAKAGI, Toshiaki F ...2004 Volume 43 Issue 2 Pages 99-103
Published: March 22, 2004
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSObjective: We studied the following: 1. Relationship between small transitional cell carcinoma (TCC) cells in voided urine and cellular grades of TCC (C-G).
2. Differential diagnosis of benign atypical small urothelial cells (BASUC) and TCC cells.
Study Design: 1. Subjects were 60 patients with TCC for whom we measured maximum and minimum diameters of 20 cancer cells in voided urine and calculated the mean value in each case.
2. Subjects were 27 occurrences of BASUC in voided urine in 24 patients (Group 1) and 15 occurrences showing C-G1 cells in 12 patients (Group 2).
We investigated the existence of irregularity in the shape of the nuclear margin and in the nucleolus and cellular piling.
Results: 1. The mean nuclear diameter (maximum/minimum) of C-G1, 2, and 3 were 7.9/5.9, 10.0/7.7 and 11.4/8.8μm on the long axis. The minimum mean value of the maximal nuclear diameter of both C-G2 and G3 was 8.8μm, below which 90% of CG1 cases were included.
2. Three-dimensional nuclear irregularity was found in 19% of Group 1 cases and 80% of Group 2.
Conclusion: A differential diagnostic feature between BSAUC and C-G1 cells was the presence of 3-dimensional nuclear irregularity.
The dividing value for the mean maximum nuclear diameter between C-G1 and both C-G2 and 3 was 8.8μm.View full abstractDownload PDF (2805K) -
Masaaki JITSUHARA, Nobuo ITOH, Takashi KITAMURA, Osamu SENGA, Sin-ichi ...2004 Volume 43 Issue 2 Pages 104-110
Published: March 22, 2004
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSObjective: We discuss typical cytological features of invasive micropapillary carcinoma (IMPC) and propose a new cytological IMPC subclassification for the breast.
Study Design: Subjects were 10 cases of IMPC studied by routine cytological, histological, and ultrastructural examination, and 3-dimensional structure were examined with confocal laser scanning microscopy to recognize IMPC features. The cytological features were compared with these examined ones to reveal cytological characteristics.
Results: Typical cytology of IMPC involved the presence of 3-dimensional cell clusters (3DCCs) composed of 50 to 100 cells classified into 2 subtypes: lumen-forming and solid. Of the 10, 6 were classified as lumen-forming and 4 as solid. Differences among them included: 1) larger nuclear size and atypia more distinct in solid than lumen-forming type; 2) more dispersed cells in solid than lumen-forming type; 3) nuclear arrangement of the most external layer of 3DCCs more irregular in solid than lumen-forming type; and 4) a less frequently observed fluffy appearance of the 3DCC rim in solid than lumen-forming type. The MIB-1 index of the solid type was higher than that of the lumenforming type.
Conclusion: Generally, the cytological feature of IMPC is the presence of 3DCCs. We found IMPC was cytologically subclassified into solid and lumen-forming. The solid type showed more dispersed cells with 3DCCs, while the lumen-forming type showed typical 3DCCs with a fluffy appearance. In breast aspiration biopsy cytology, it is therefore important that the solid type should be taken into consideration and be differentiated from the typical lumen-forming type in diagnosing IMPC.View full abstractDownload PDF (10533K) -
Yukari OBANA, Shotaro MAEDA, Masaru HOSONE, Hironori KATAYAMA, Toshits ...2004 Volume 43 Issue 2 Pages 111-116
Published: March 22, 2004
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Clear cell chondrosarcoma is very rare, accounting for 2.2 % of chondrosarcoma. It is often cytologically difficult to differentiate clear cell chondrosarcoma from other bone tumors, e.g. osteosarcoma, giant cell tumor of the bone, chondrosarcoma, and chondroblastoma. We report a case of clear cell chondrosarcoma.
Case: A 30-year-old male complaining of pain in the right hip joint was found on plain X-ray to have a radiolucent lesion in the head and neck of the right femur. Biopsy was performed and a touch smear was also prepared. Cytologically, numerous and monotonous stromal cells with oval to round nuclei and osteoblastic multinucleated giant cells were observed, as were osteoid and cartilaginous substances. Histologically, osteosarcoma was suspected mainly from the osteoid, bone, cartilage, and multinucleated giant cells. Cellular atypia of the tumor cells was not great enough, tumor cell cytoplasm was clear, and no high-grade malignant tumor could be considered clinically from the plain Xray. So a definitive diagnosis of osteosarcoma was ruled out. The case was eventually diagnosed as clear cell chondrosarcoma.
Conclusion: We emphasize that clear cell chondrosarcoma should be diagnosed from the overall findings of clinical information, a plain X-ray, cytology, and histology.View full abstractDownload PDF (7300K) -
Fumiko TAGUCHI, Yukitoshi SATO, Yuichi ISHIKAWA, Rira HOSHI, Masafumi ...2004 Volume 43 Issue 2 Pages 117-120
Published: March 22, 2004
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: We report a rare case of primary clear cell carcinoma of the lung.
Case: A 39-year-old man with fever and swelling of the right neck was diagnosed with clear cell carcinoma by histologic examination of the neck tumor. Chest radiography and computed tomography (CT) showed lung tumor 2cm in diameter, at right S1 and multiple small nodules in both lungs. Transbronchial aspiration cytology (TBAC) yielded a definitive diagnosis of clear cell carcinoma. He was diagnosed with primary lung cancer by the exclusion of other organic origin. He underwent 1 course of chemotherapy but died of cancer progression. The diagnosis of primary clear cell carcinoma of the lung was confirmed by autopsy.
Conclusion: Primary clear cell carcinoma of the lung must be discriminated from metastasis from renal cell carcinoma. We found that cytologic findings such as cell size, aspects of cytoplasm, and prominent nucleoli differentiated this disease from metastatic tumor from clear cell renal cell cacinoma type.View full abstractDownload PDF (3693K) -
Keiji SHIMADA, Mitsutoshi NAKAMURA, Eiwa ISHIDA, Noboru KONISHI2004 Volume 43 Issue 2 Pages 121-124
Published: March 22, 2004
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: We report cytological and histological findings on squamous cell carcinoma components in anaplastic carcinoma of the thyroid.
Case: A 83-year-old woman reporting hoarseness and swelling on the right side of the neck was found in aspiration cytology to have a number of polymorphous nuclear cells with a group of follicular epithelial cells. In other parts, a few keratinized ghost cells appeared in the background of necrotic debris. She died of cancer of the mediastinum.
Autopsy findings showed that cancer cells with scattered single-cell keratinization were mainly involved in the right lobe of the thyroid, and were positive for high molecular weight cytokeratin and thyroglobulin, supporting the diagnosis of anaplastic carcinoma of the thyroid.
Conclusion: Immunocyto-or immunohistochemical analysis of thyroglobulin combined with cytokeratin is useful in determining the origin of squamous cell carcinoma of the neck and making a difinitive diagnosis.View full abstractDownload PDF (4190K) -
Masafumi TOYOSHIMA, Hitoshi NIIKURA, Nobuo YAEGASHI, Kazunosuke ABE, M ...2004 Volume 43 Issue 2 Pages 125-129
Published: March 22, 2004
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Lymphatic metastasis, equivalent to disseminated metastasis, leads in progressive epithelial ovarian carcinoma. Ovarian carcinoma detected by superficial inguinal lymph cytology is very rare.
Case: A 52-year-old woman with left inguinal lymph node swelling underwent by aspiration cytology to determine malignant cells from the ovary. Open biopsy of the left superficial inguinal lymph node led to a diagnosis of lymph node metastasis from serous papillary adenocarcinoma of the ovary. At surgery, we found no obvious carcinoma in the pelvic cavity and both ovaries were macroscopically normal. Immunohistochemistry showed tumor cells to be positive for CK7, EMA, and Ber-EP4 and negative for CK20, calretinin, and vimentin.
Conclusion: We report a rare case of normal-sized ovary carcinoma syndrome with superficial inguinal lymph node metastasis.View full abstractDownload PDF (6664K) -
Tomoyuki MIYAMOTO, Yukari NISHIMURA, Manabu HATTORI, Hirokuni KAKINUMA ...2004 Volume 43 Issue 2 Pages 130-134
Published: March 22, 2004
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Ovarian strumal carcinoid is a rare tumor. We report imprint-cytological and immunohistochemical findings of this tuor using double stainingl.
Case: A 59-year-old woman with abdomina distension and chronic constiation was found in Mri to heve a left ovarina tumor 8.0×9.0 cm in size. Imprint cytology showed that tumor cells with light-green stained granular cytoplasm, oval to round nuclei, and coarse granular chromatin were arranged in trabecular or rosette-like formations. Follicles containing colloid were also seen. These findings suggest that the tumor was ovarian srumal carcinoid. Immunohistochemically, thyrogloblin and thyroid transcriptional factor-1 were positive in strumal and transitional structures. Chromogranin A was positive in strumal and carcinoid structures and peptide YY was positive in carcinoid.
Conclusion: The typical arrangement of tumor cells and follicular structure with colloid are considered essential for the diagnosis of ovarian strumal carcinoid. Histochemical study suggests that this tumor originates in cells of the strumal follicle.View full abstractDownload PDF (9162K) -
Toru KIKUTSUGI, Tetsuo HAMADA, Tokuhide YOSHIDA, Shigemasa KANAZAWA, M ...2004 Volume 43 Issue 2 Pages 135-139
Published: March 22, 2004
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: The primitive neuroectodermal tumor (PNET) is a soft tissue tumor with neuroectodermal differentiation currently assigned to Ewing's tumor/PNET family. We report a case of PNET of the uterus presenting the peculiar clinical feature of an endocervical polyp.
Case: A 52-year-old Japanese woman with and suspected of cervical leiomyoma underwent polypectomy followed by cytological examination. A large number of atypical small round cells was seen in scattered or clustered cells with hemorrhagic and inflammatory back ground in the cervical smear. Tumor cells had hyperchromatic nuclei with a thin nuclear rim and small nucleoli. Rosette-like structures were identified in part of clusters, suggesting neuroectodermal differentiation. Histopathologic examination showed diffuse proliferation of atypical small round cells with many mitotic figures and with Homer-Wright rosettes or perivascular pseudorosette structures. Immunohistochemically, CD99 stained positively in the tumor cell membrane. Cytokeratin, vimentin, chromogranin-A, synaptophysin, NSE, and S-100 protein were positive in cells.
Conclusion: PNET should be taken in account in the differential diagnosis of malignant small round cell tumors of the uterus, because reported cases of uterine PNET have recently increased in number.View full abstractDownload PDF (4013K)
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