All issues
Volume 43, Issue 5
Displaying 1-8 of 8 articles from this issue
- |<
- <
- 1
- >
- >|
-
Ritsuko IMAI, Sonoko NATSUME, Masako HASHIMOTO, Rie TAKAGI, Toshiaki F ...2004 Volume 43 Issue 5 Pages 311-315
Published: November 22, 2004
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSObjective: To study the significance of nuclear grooves in order to differentiate transitional cell carcinoma (TCC) grade 1 cells from benign atypical small urothelial cells (BASUC).
Study Design: Normal urothelial cells (8 cases, 8 specimens) obtained by urinary bladder lavage, BASUC (15 cases, 16 specimens) in voided urine and TCC cells of grade 1, 24 cases 35 specimens; grade 2, 9 cases 12 specimens; and grade 3, 11 cases 13 specimens in voided urine were used.
In each specimen, more than 20 nuclei were studied and nuclear grooves were expressed as a percentage. Nuclear grooves were classified into type 1 (a single longitudinal groove), type 2 (various directional short grooves) and type 3 (various directional long grooves).
Results: The incidence of nuclear grooves was 35% in BASUC, and 77%, 56% and 68% in TCC cells grade 1, 2 and 3, respectively. The difference between TCC G1 cells and BASUC was statistically significant in terms of the incidence but not in the type of nuclear grooves (p<0.01, t-test).
Conclusion: The incidence of nuclear grooves is useful information to differentiate TCC G1 cells from BASUC.View full abstractDownload PDF (3039K) -
Ryuji YABUSHITA, Tsutomu MIYAJI, Takahiro MORI, Kohhei OHSHIMA, Michir ...2004 Volume 43 Issue 5 Pages 316-320
Published: November 22, 2004
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSObjective: Negative cervical smears were reexamined before reporting results, in quality control. We also examined smears using cytonavigation with a Focal Point, which we rented in February 2003. We compared the results of 2 methods, i. e., reexamination of easily overlooked parts of smears by cytotechnologists and reexamination by cytonavigation.
Study Design: All smears were negative in this study. Cervical smears of 52, 250 cases from February 2001 to May 2003 were reexamined by cytotechnologists, and 36, 722 cases from July 2002 to April 2003 by cytonavigation.
Results: Before introducing quality control, the rate of overlooked parts of smears was 0.43%. After reexamination of easily overlooked parts of smears by cytotechnologists, overlook error improved to 0.15%. It was also improved to 0.15% by cytonavigatoin.
Conclusion: Reexamination of easily overlooked parts of smears is very important in accurately diagnosing cytopathology, in addition to objective cytonavigation.View full abstractDownload PDF (3568K) -
Miho YAMADA, Manabu HATTORI, Masaru YOKOYAMA, Hirokuni KAKINUMA, Jun W ...2004 Volume 43 Issue 5 Pages 321-326
Published: November 22, 2004
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Rhabdomyosarcoma arising from the chest wall is rare. We report imprint-cytological findings of this tumor.
Case: A 31-year-old man with left chest pain was found in chest X-ray and CT to have a large mass protruding into the left thoracic cavity. Imprint cytology of the resected tumor showed (1) loosely arranged pleomorphic cells, (2) a variety of cell sizes with mono-or multinucleation, (3) thick and granular cytoplasm, (4) round to pleomorphic nuclei with maldistribution. Immunocyto-and histochemical staining showed tumor cells were positive for myoglobin, desmin, and HHF35.
Conclusion: Rhabdomyosarcoma showed characteristic cytologic findings that provide an accurate cytologic diagnosis.View full abstractDownload PDF (6496K) -
Toshiharu MAEDA, Keizo FURUYA, Tomoko FURUYA, Nobuyuki INOUE, Kosho KI ...2004 Volume 43 Issue 5 Pages 327-330
Published: November 22, 2004
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Papillary meningioma is a rare variant of meningioma. We reported a case of papillary meningioma demonstrating the efficacy of crush preparation cytology.
Case: A 18-year-old woman reporting headache and gait disturbance was found in MRI to have a right skull base tumor. thought to be meningioma or schwannoma. Intraoperative pathological examination was done to confirm the clinical diagnosis. Frozen sections showed tumor cells with wide cytoplasm, arranged in a solid sheet, rarely with a pseudorosettelikestructure. Crush preparation cytology showed densely packed cell clusters with a papillary structure with a fibrovascular core. Nuclei were round to oval and uniform, indicating papillary meningioma. Postoperative paraffin-embedded sections showed papillary proliferation of tumor cells with a fibrovascular core. Immunohistochemically, tumor cells were positive for EMA and cytokeratin (AE1/AE3).
Conclusion: Crush preparation cytology used in addition to frozen sections is useful for intraoperative pathological examination of brain tumors.View full abstractDownload PDF (5830K) -
Immunostaining efficacy in intraoperative diagnosisHironori KATAYAMA, Shotaro MAEDA, Masaru HOSONE, Hiroshi HARA, Naoko S ...2004 Volume 43 Issue 5 Pages 331-334
Published: November 22, 2004
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Cytology is useful in the intraoperative diagnosis of brain tumors because it is sometimes difficult to diagnose brain tumors correctly by HE stained frozen sections alone due to the presence of frozen artifacts.
We report a case of gemistocytic glioblastoma in which intraoperative rapid cytology and immunostaining were effective.
Case: A 50-year-old woman with a bad headache in the left temporal area was found in CT to have a 3×2 cm tumor in the left frontal lobe. Craniotomy and rapid intraoperative diagnosis were done.
Cytologically, numerous round and oval tumor cells with a high N/C ratio were observed with cyanophilic cytoplasm and eccentrically located atypical nuclei. Histologically, findings were basically the same as cytological findings. Gemistocytic glioblastoma was considered most likely, but metastatic adenocarcinoma and lymphoma could not be ruled out.
A 10-minute rapid immunostaining done for differential diagnosis confirmed glioblastoma because GFAP was positive but keratin and LCA were negative for tumor cells.
Conclusion: A combination of cytology and immunostaining is useful for rapid intraoperative diagnosis of gemistocytic glioblastoma.View full abstractDownload PDF (3041K) -
Yasue SHITARA, Wataru TAKAHASHI, Rie SHIBATA, Yukihiko MORIKAWA2004 Volume 43 Issue 5 Pages 335-339
Published: November 22, 2004
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Infantile adrenal cortical carcinoma is rare and, in diagnosis, requires careful examination.
Case: A 4-year-old girl showed an abdominal tumor and virilization, with elevated adrenal androgen in serum and urine. The resected adrenal tumor was encapsulated, soft and fragile, reddish-brown, 12.0×8.0-7.5cm, and 430g in weight, with a hemorrhagic necrotic cut section with cystic degeneration.
Cytology disclosed hypercellularity in the necrotic hemorrhagic background. Tumor cells showed loss of cohesion and were swollen with granular cytoplasm. They also had large hyperchromatic nuclei with coarse chromatin. Multinucleated cells and intranuclear inclusion were seen occasionally.
Histologically, tumor cells showed acidophilic cytoplasm forming diffuse solid nests. Nuclei of tumor cells were bizarre and hyperchromatic with occasional multinucleation.
Electron microscopy showed abundant smooth rough-surfaced ERs, round mitochondria with tubular cristae, lipid droplets, and irregularly shaped nuclei.
Conclusion: Histopathological and cytological findings of the tumor are analogous to those seen in androgen-producing adrenal cortical carcinoma (APACC).
When diagnosing a rare infantile APACC, sufficient examination with special reference to the extent of cellular atypism and tumor size is essential, requiring endocrinological findings.View full abstractDownload PDF (9110K) -
Hiroyuki ENDOU, Noriko ISHIHARA, Kentaro HIURA, Hiromi MIKI2004 Volume 43 Issue 5 Pages 340-344
Published: November 22, 2004
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Matrix-producing carcinoma (MPC) is a rare variant of breast carcinoma.
Case: A 37-year-old woman with a palpable mass in the left breast underwent excisional biopsy followed by mastectomy with lymph-nodal dissection. She died about 1 year after surgery due to extensive metastasis. The tumor was 5.5 cm in diameter and showed a myxoid appearance. Histological examination showed invasive ductal carcinoma (solid tubular carcinoma) at the periphery. Tumor cells showed direct transition into a centrally located myxoid chondromatous area. These features were consistent with MPC. Lymph-nodal metastasis consisted solely of the myxoid component. Immunohistochemically, tumor cells of both conventional invasive carcinoma and the myxoid chondromatous area showed almost the same results: positivity for cytokeratin, EMA, and S-100 protein. Fineneedle aspiration specimens from biopsy material showed many malignant-appearing cells in an abundant myxoid matrix. Loosely arranged aggregation of tumor cells showed gradual transition into isolated cells. Tumor cells encircled the myxoid matrix in part.
Conclusion: Cytologically, MPC features loosely arranged or isolated malignant cells in an abundant myxoid matrix without intervening spindle cells and is devoid of features of osteosarcoma and/or chondrosarcoma.View full abstractDownload PDF (8319K) -
Tatsuaki TOYOOKA, Aya IWANAGA, Yuichi YAKATA, Ryuta OKU, Shinji NAITO2004 Volume 43 Issue 5 Pages 345-346
Published: November 22, 2004
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSWe report a rare case of inflammatory pseudotumor arising in the left submandibular gland. A 74-year-old man underwent selective neck dissection for a left submandibular gland mass. Imprint cytological examination of the specimen revealed numerous lymphocytes, plasma cells and myofibroblastic cells. Histopathology showed fibroblastic spindle cells with numerous mature plasma cells arranged in poorly formed fascicles and in a vaguely storiform pattern. The lesion mass was diagnosed as an inflammatory pseudotumor. Thus, diagnosis could be hypothesized from the cytological findings alone.View full abstractDownload PDF (3804K)
- |<
- <
- 1
- >
- >|