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Volume 44, Issue 5
Displaying 1-9 of 9 articles from this issue
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Rieko NISHIMURA, Norihiro TERAMOTO, Masayuki YAMAUCHI, Tamami YAMAMOTO ...2005 Volume 44 Issue 5 Pages 273-278
Published: September 22, 2005
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSObjective: Cancer cell detection in the surgical margins of breastconserving surgical specimens using imprint cytology is becoming important procedure. Therefore, the cytological characteristics of breast ductal carcinoma in situ (DCIS) as revealed by imprint cytology should be evaluated.
Study Design: We prepared imprint cytology specimens from the cut surface of breast cancers that had been surgically resected at our hospital. A histological section of the cut surface was also made. The specimens were classified as non-invasive (16 cases) or microinvasive ductal carcinoma (9 cases) based on the histology of the imprinted surface. The cytology and histology results were compared for each case.
Results: Malignancies were diagnosed in specimens with comedonecrosis (5 cases), cribriform findings (4 cases), micropapillary findings (5 cases), and in two solid tumors with a high nuclear grade. Malignancies were difficult to distinguish from benign diseases in cases with papillary findings (6 cases) and in cases with solid or micropapillary findings with a low nuclear grade (3 cases). Myoepithelium was detected in six cases. A fibrotic core was not detected on the imprinted slides, even in specimens with papillary findings.
Conclusion: The cytological features of DCIS revealed by imprint cytology can be divided into two types: one which was easy diagnosed as a carcinoma and the other which was difficult to distinguish from benign diseases. Accurate histology finding may be more difficult to obtain using imprint cytology than by using aspiration cytology.View full abstractDownload PDF (4021K) -
Correlation of aspiration cytology and stage of infarctionAkinori ISHIHARA, Hideyuki KOYAMA, Shinji IHARA, Miho KAWAI, Tomoko OG ...2005 Volume 44 Issue 5 Pages 279-283
Published: September 22, 2005
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSObjective: We studied the correlation between cytological features and the stages of infarcted intraductal papilloma of the breast.
Study Design: Seven cases with localized or massive infarctions of intraductal papilloma of the breast were studied.
Results: In the early stage of infarcted intraductal papilloma, numerous degenerative cells and necrotic debris were observed. Isolated degenerative cells exhibited columnar, spindle, polygonal and fiber-like cells with hyperchromatic and smudged nuclei. Ghost cells were also seen. Extensive necrosis was observed in a few sheets of ductal cells at the progressive stage. In the regenerative stage, clusters of fibroblasts, ductal cells and necrotic debris were found.
Conclusions: The cytological findings at various stages of infarcted intraductal papilloma of the breast were characterized. In the absence of viable ductal cells within the specimen, a distinction between benign and malignant lesions may be difficult. A breast biopsy is necessary to make a diagnosis in indeterminate cases.View full abstractDownload PDF (2310K) -
A diagnostic flow-chart by the new reporting form of breast cytologyAkinori ISHIHARA, Tomoko OGAWA, Hirohiko TANAKA2005 Volume 44 Issue 5 Pages 284-290
Published: September 22, 2005
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSObjective: To develop a diagnostic evaluation method based on the presence of necrotic debris in breast aspirates.
Study Design: A total of 906 cytological materials obtained by breast FNA were investigated. The present study included 524 malignant and 382 benign lesions.
Results: Necrotic debris was observed in 173 of the breast lesions. Of these lesions, 151 (87.3%) were malignant and 22 (12.7%) were benign. Comedo-type carcinoma in non-invasive ductal carcinoma and papillotubular carcinoma had the highest incidences. Massive calcification with necrotic debris strongly indicates a comedo type carcinoma of the breast. Cytology obtained from infarcted breast lesions revealed scattered necrosis with extensive degenerated columnar, polygonal and spindle cells, occasional hyperchromatic epithelial cells and ghost cells. Viable epithelial and stromal cells provided valuable diagnostic information. Materials mimicking necrotic debris were also investigated.
Conclusions: Cytologic features and the diagnostic evaluation of necrotic debris in breast FNA specimens are usefull for the differential diagnosis of breast lesions.View full abstractDownload PDF (3796K) -
Junji SANO, Naoko YOSHIMOTO, Yoshikazu MIZOGUCHI, Michiko SAITO2005 Volume 44 Issue 5 Pages 291-297
Published: September 22, 2005
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSObjective: Cytological and histological findings were obtained using the cell block method and sodium alginate (SA).
Study Design: Washing liquid from the Endobrush or Enclocyte, the FNA needle, and the bronchial scratch brush was sampled. The SA method and the kimwipe method were then compared.
Results: Samples that exhibited the usual cell clumping when examined using the smear method showed clear histological characteristics when examined using the SA method. Good preparations were obtained using the SA method when the samples had a small number of cells.
Conclusion: Cytological and histological specimens can be simultaneously obtained using the SA method, allowing a more accurate diagnosis.View full abstractDownload PDF (4982K) -
Chie SAMEJIMA, Takashi KITAMURA, Hitoshi NEGAMI, Yoshiko TSUDA, Genshu ...2005 Volume 44 Issue 5 Pages 298-303
Published: September 22, 2005
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Breast malignant lymphomas (ML) are rare among breast malignant neoplasms. We here report the cytological features of five cases of breast ML.
Cases: The five women ranged in age from 52 to 84 years old. The chief complaints of all the cases were breast masses, and the tumor size ranged from 2.1 to 8.7 cm. Regional lymph node metastasis was observed in one case, and the cytological features in this case showed the largest lymphoma cells among the five cases. The cytological findings of the fine needle aspiration (FNA) cytology specimens obtained in all the cases showed abundant single neoplastic cells and also revealed lymphoglandular bodies in the background. Neoplastic cells were relatively small with a high N/C ratio. The nuclei were hyperchromatic and possessed large and prominent nucleoli. Chromatin was fine and granular. Two cases showed irregular-shaped nuclei. Based on these cytological characteristics, the cytological diagnosis in all the cases was ML. The diagnosis of ML was confirmed by post-operative histological examinations, and the classification of ML was diffuse large B cell lymphoma in all five cases. A mastectomy was performed by in all the cases and followed by chemotherapy in four cases.
Conclusion: The cytological diagnosis of all reported cases of breast ML has been malignant, suggesting a histological diagnosis of ML. Therefore, this report showed that FNA cytology is a valuable examination for the diagnosis of breast ML. More detailed histological subclassifications and analyses of immunohistochemical prognostic factors, such as CD5, bcl-2 and p53, are necessary for the prognostic evaluation of breast ML.View full abstractDownload PDF (2993K) -
Makoto YAMADA, Shin-ichi SHIMIZU, Fumiko SAKATA, Yurika SAWAKI, Yasuhi ...2005 Volume 44 Issue 5 Pages 304-308
Published: September 22, 2005
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: We report a case of alveolar rhabdomyosarcoma showing peculiar tumor dissemination. Cytological features of tumor cells in body fluid resemble those of DSRCT.
Case: A 16-year-old boy admitted for dyspnea on exertion was found to have body fluids accumulated in pleural effusion, pericardial effusion, and ascites. Cytological specimens from pericardial and pleural effusion contained many tightly cohesive clusters of homogenous tumor cells, i. e., small and round with high a N/C ratio. Concentric nuclei showed mild irregularity with finely granular chromatin and inconspicuous nucleoli. Binucleated tumor cells, intracytoplasmic inclusions, and fibrillary material were not identified. Gland-like arrangements and nuclear moldings were occasionally identified. At autopsy, the tumor showed proliferation in an alveolar growth pattern with fibrous stroma mainly in serosal membranes. Tumor cells showed positive immunoreactivity for vimentin, desmin, myoglobin, and myogenin. Chromosomal analysis showed chimera gene PAX3-FKHR. Based on these findings, we diagnosed the tumor as alveolar rhabdomyosarcoma.
Conclusions: It is difficult to make a definite diagnosis of small round cell tumors are difficult to diagnose definitively based on cytological findings alone. It is thus essential in correctly diagnosing these tumors to evaluate clinical data, histological and immunohistochemical findings, and chromosomal analysis.View full abstractDownload PDF (2407K) -
Tadashi SAITO, Jun-ichi TAMARU, Junko KAYAO, Yoshihiko KUZUU, Hiroko O ...2005 Volume 44 Issue 5 Pages 309-313
Published: September 22, 2005
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: We report a case of de novo CD5-positive diffuse large B-cell lymphoma demonstrating a cohesive growth pattern resembling that of carcinoma cell-clusters.
Case: A Japanese woman in her mid-seventies presented with general fatigue and systemic peripheral lymphadenopathy. Bone marrow aspirates and a lymph node biopsy specimen showed atypical cell-clusters. The tumor cells exhibited a cohesive growth pattern similar to that of carcinoma cell-clusters. Cytomorphological findings for tumor cells obtained from the bone marrow and lymph node suggested metastatic carcinoma. An immunohistochemical study, however, showed that the tumor cells were CD5+ and CD20+ but CD21-and Cyclin Dl-. Surface marker analysis using flow cytometry showed the tumor cells to be CD5+, CD19+, and CD20+but CD10-and CD23-. Consequently, a diagnosis of de novo CD5-positive diffuse large B-cell lymphoma was established based on the results of the immunophenotyping study.
Conclusion: In this case, the cytomorphological findings for the tumor cells obtained from bone marrow aspirates and a lymph node biopsy needed to be distinguished from those of metastatic carcinoma. We concluded that a detailed cytological study and immmunophenotyping are indispensable for the correct diagnosis of malignant lymphoma.View full abstractDownload PDF (2928K) -
Katsuaki SATO, Yoshiko UWAMI, Josaku KAWAMURA, Kazuo TANIMOTO, Keiko O ...2005 Volume 44 Issue 5 Pages 314-318
Published: September 22, 2005
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Adenoendocrine cell carcinoma (AEC) arising in the bile duct is extremely rare. We report a case of AEC consisting of large cell neuroendocrine carcinoma (LCNEC) and adenocarcinoma of the inferior bile duct, focusing on cytological features.
Case: A 68-year-old man experiencing appetite loss 1 month before hospital admission was found to have jaundice. CT showed a tumor in the inferior bile duct. Adenocarcinoma was diagnosed basedon brushing cytology, necessitating pancreaticoduodenectomy. Histological examination showed that the tumor mainly consisted of LCNEC and well-differentiated tubular adenocarcinoma occupying a small area in the superficial portion. Tumor cells in the LCNEC component were immunoreactive for chromogranin A. We diagnosed the tumor as AEC. Further cytological examination showed 2 different types of carcinoma cell clusters-one of carcinoma cells with vesicular nuclei with coarsely granular chromatin and prominent nucleoli and abundant cytoplasm, and the other with a sheet-like rather than clustered appearance consisting of carcinoma cells with nuclear feaures similar to the former but with less prominent nucleoli. The patient died of liver metastasis 3 months after surgery.
Conclusion: It is important to recognize AEC in bile ducts, since the tumor has an extremely poor prognosis.View full abstractDownload PDF (3163K) -
Katsuaki SATO, Yoshiko UWAMI, Yasuyo NISHIDA, Kazuo TANIMOTO, Yoshimic ...2005 Volume 44 Issue 5 Pages 319-322
Published: September 22, 2005
Released on J-STAGE: November 08, 2011
JOURNAL FREE ACCESSBackground: Anaplastic thyroid carcinoma is usually transformed from differentiated thyroid carcinoma at the primary site. We report a rare case of anaplastic carcinoma with a rhabdoid phenotype transformed from well-differentiated papillary thyroid carcinoma in a metastatic focus of the cervical lymph node, and focus on cytological features.
Case: A 77-year-old man presented with a mass rapidly growing in the right neck 2 weeks before being seen was found in CT to have a mass in the right lateral neck invading the right sternocleidomastoid muscle and an other mass in the upper right lobe of the thyroid gland, necessitating right hemithyroidectomy and neck dissection. Intraoperative imprint cytology of the lateral cervical tumor showed highly atypical sarcomatoid cells with vesicular nuclei with coarsely granular chromatin and prominent nucleoli. Atypical pleomorphic cells with paranuclear hyaline inclusions in cytoplasm were also observed. Histological examination showed that the thyroid tumor was well-differentiated papillary carcinoma, while the lateral cervical tumor was anaplastic carcinoma with a rhabdoid phenotype, considered to be a lesion transformed from metastatic papillary carcinoma in a lymph node.
Conclusion: This rare subtype of thyroid carcinoma with a rhabdoid phenotype should be considered when differentially diagnosing cervical tumors.View full abstractDownload PDF (2274K)
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