We report a rare case of cervical ectopic thymoma. A 54-year-old man was found in computed tomography (CT) to have a nodule below the lower pole of the left lobe of the thyroid. Fine-needle aspiration cytology showed spindle cell clustersintermingled with small lymphocytes. The tumor was resected together with the left thyroid lobe and diagnosed histologically as cervical ectopic thymoma. Giventhe rarity of this tumor, fine-needle aspiration cytology assists in correct diagnosis.
The case of a 67-year-old woman with a solid breast neuroendocrine carcinoma is presented. Cytological findings for breast neuroendocrine carcinoma have rarely been described. Cytopathologic examination using a fine needle aspiration (FNA) sample of the tumor revealed clusters of relatively uniform tumor cells. The tumor cells had round to oval nuclei with little to mild atypia, fine granular chromatin, and showed rosette formation. These features strongly suggested a neuroendocrine tumor, which was confirmed by a histopathologic examination of the resected specimen. The diagnosis of neuroendocrine carcinoma was further confirmed by immunostaining for neuron-specific enolase/chromogranin A/synaptophysin. Preoperative FNA successfully predicted this special type of breast carcinoma.
We evaluated the feasibility of cervical cytology and human papillomavirus (HPV) testing, analyzing 67 patients cytologically diagnosed with at least mild dysplasia. Positive criteria of cytology, histology, and HPV tests were class HSIL or greater, CIN2 or more, and HPV index >1. The gold standard was punch biopsy histology. The sensitivity of cytology was 47.7%, 86.4% HPV testing and both 89.3%. The negative predictivity of cytology, was 67.6%, 87.0% HPV testing and both 83.3%. Cervical screening with both cytology and HPV testing effectively distinguishes the disease requiring treatment.