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Volume 46 (2007)
- Issue 6 Pages 315-
- Issue 5 Pages 251-
- Issue 4 Pages 197-
- Issue 3 Pages 135-
- Issue 2 Pages 71-
- Issue 1 Pages 1-
Volume 46, Issue 6
Displaying 1-5 of 5 articles from this issue
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Original Articles
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Seiko OGURA, Takaki SAKURAI, Keiko SHIMIZU, Satsuki EGI, Yoshiaki NORI ...2007 Volume 46 Issue 6 Pages 315-322
Published: November 22, 2007
Released on J-STAGE: July 18, 2008
JOURNAL FREE ACCESSObjective : We review the cytological features of grade 1 urothelial carcinoma.
Study Design : We reclassified 154 urinary bladder biopsies classified as grade 1 urothelial carcinoma based on the general rules for clinical and pathological studies on bladder cancer under new WHO classification by one pathologist. We review cytological diagnosis of reclassified cases and cytological features.
Results : Reclassified diagnosis was distributed as follows : 28 papillary urothelial neoplasms of low malignant potential (PUNLMP), 108 papillary urothelial carcinoma, low grade (low UC), and 15 papillary urothelial carcinoma, high grade (high UC). Cytological results showed significant differences between PUNLMP and low UC (p<0.05) and between PUNLMP and high UC (p<0.01).
Conclusion : The existence of PUNLMP cases appears to be one reason that lowers the positive rate of cytodiagnosis in voided urine decrease. The observation of small isolated urothelial cells is important in the cytological diagnosis of PUNLMP.View full abstractDownload PDF (746K) -
Nobuhiko AKIU, Mareyuki ENDOH, Michiyo ISAWA, Katsumasa KUMAGAI, Maki ...2007 Volume 46 Issue 6 Pages 323-331
Published: November 22, 2007
Released on J-STAGE: July 18, 2008
JOURNAL FREE ACCESSObjective : We evaluated a new breast cytology reporting system (Japanese Society of Breast Cancer : Guideline), reviewing 15,470 cases of fine-needle aspiration cytology (FNAC) dividing into pre- and post-Guideline occurrence).
Study Design : We compared the proportion of each diagnostic category among all cases and the attainment of actual and the numerical targets by of the Guideline pre- and post-Guideline. We conducted standard quality assurance (QA) at UK. We also analyzed the results of additional FNAC for malignant lesions not accurately diagnosed in initial examination.
Results : After the Guideline was introduced, the ratio of “suspicious for malignancy” cases increased, while those of the inadequate/indeterminate ratio decreased. We could not determine the proposal ratio of “malignant lesions among suspicious cases” or false-negative ratio, however. Of cases underdiagnosed or clinically suspicious, only 18.5% were accurately diagnosed in FANC reexamination of FNAC both before and after Guideline introduction.
Conclusion : The Guideline, being evidence-oriented, made it easier to conduct quality assurance, including QA. The Guideline was enlightening to both surgeons and cytologists.View full abstractDownload PDF (411K) -
Kenzo IKEMOTO, Tomoko FURUYA, Atsunori OGA, Shigeto KAWAUCHI, Shigeru ...2007 Volume 46 Issue 6 Pages 332-337
Published: November 22, 2007
Released on J-STAGE: July 18, 2008
JOURNAL FREE ACCESSObjective : The purpose of this study was to elucidate the relationship between chromosomal instability (CIN) and phenotypic changes in invasive ductal carcinoma of the breast.
Study Design : The material used in this study was 121 invasive ductal carcinomas. DNA ploidy was measured by laser scanning cytometry (LSC), and CIN was assessed by fluorescence in situ hybridization (FISH) with centromeric DNA probes for chromosomes 7, 11, 17, and 18. The tumors were tested for expression of estrogen and progesterone receptors (ER and PgR, respectively) and test for expression of Ki-67 by immunohistochemistry. FISH was also used to test for HER-2 amplification. Nuclear grade was determined histologically and cytologically.
Result : The breast cancers consisted of 47 diploid tumors and 74 aneuploid tumors. Assessment of CIN revealed that 44 (94%) of the diploid tumors were negative and 71 (96%) of the aneuploid tumors were positive. Both ER and PgR were expressed in 74% of the CIN-negative tumors, but neither was expressed in 49% of the CIN-positive tumors (p<0.05). HER-2 amplification was detected in only six (13%) of the CIN-negative tumors, but it was present in 35 (47%) of the CIN-positive tumors (p<0.0001). High Ki-67 expression was detected in 13 (28%) of the CIN-negative tumors and in 52 (70%) of the CIN-positive tumors (p<0.0001). A higher percentage of high-grade carcinomas than low-grade carcinomas were CIN-positive (p<0.0001).
Conclusion : DNA ploidy and CIN were closely associated with the phenotypic characteristics of invasive ductal carcinomas of the breast, including expression of hormone receptors.View full abstractDownload PDF (464K) -
Shouji KAKU, Yuko SUGIYAMA, Yuji ARAI, Reiko FURUTA, Futoshi AKIYAMA, ...2007 Volume 46 Issue 6 Pages 338-343
Published: November 22, 2007
Released on J-STAGE: July 18, 2008
JOURNAL FREE ACCESSObjective : Lymphoepithelioma-like carcinoma (LELC) of the uterine cervix, a rare tumor, seldom metastasizes to regional nodes and has a better outcome than other types of squamous cell carcinoma. Histologically, LELC tends to be well circumscribed and surrounded by a prominent lymphocytic infiltrate. LELC is difficult to diagnose preoperatively in biopsy samples. We review cytological findings for LELC.
Study Design : We review cytological and histological specimens for 6 cases of LELC.
Results : In three of our six cases, cancer nests were cytologically associated with marked lymphocyte infiltration, but few differences in the number of lymphocytes were seen between LELC and more commonly encountered nonkeratinizing squamous cell carcinoma. LELC has finer hyperchromasia, fewer marked nucleoli, and fewer nuclear pleomorphism than glassy cell carcinoma. None of our six cases was diagnosed preoperatively as LELC.
Conclusion : Cytologically, LELC is difficult to diagnose preoperatively.View full abstractDownload PDF (547K) -
Makiko ONUMA, Toru TASE, Hiroyuku KATO, Miyuki UEKI, Miwa ABE, Mika TA ...2007 Volume 46 Issue 6 Pages 344-349
Published: November 22, 2007
Released on J-STAGE: July 18, 2008
JOURNAL FREE ACCESSObjective : Papillary squamous cell carcinoma (PSCC) of the uterine cervix is difficult to detect via evidence of stromal invasion by superficial biopsy and has a poor prognosis. We studied PSCC clinical findings, cytological usefulness, and histogenesis.
Study Design : Taking 20 cases of PSCC from Miyagi Cancer Center files from 1995 to 2005, we studied cytological and histological slides and obtained and studied tumor tissues for CK7, CK20, and p16INK4a.
Results : Atypical vaginal bleeding was a common symptom and most cases showed macroscopic features consistent with papillary invasive carcinoma. Tumor diameters were 25∼60mm, with those in 12 cases exceding 40mm. Clinical stages were 2 Ib1, 1 Ib2, 2 IIa, 10 IIb and 5 IIIb. PSCCs were classified into 8 transitional, 4 squamous, and 8 mixed based on histological features. Pap smears of all showed invasive squamous cell carcinoma with a background of tumor diathesis and small malignant cells. Immunohistochemically, all showed squamous cell carcinoma pattern for CK7 and CK20, and 19 were positive for human papillomavirus (HPV) positive for P16INK4a.
Conclusion : Cytological and macroscopic findings are useful in detecting invasive PSCC, which our results suggest is a type of squamous cell carcinoma.View full abstractDownload PDF (824K)
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