The Journal of the Japanese Society of Clinical Cytology
Online ISSN : 1882-7233
Print ISSN : 0387-1193
ISSN-L : 0387-1193
Search
Advanced search
OR
Browse
Search
Volume 46, Issue 1
Displaying 1-3 of 3 articles from this issue
Show all abstracts
    • |<
    • <
    • 1
    • >
    • >|
Original Articles
  • Aspiration cytologic features of thyroid medullary carcinoma
    Takeshi KOHNO, Kazuto YAMAZAKI
    2007 Volume 46 Issue 1 Pages 1-6
    Published: January 22, 2007
    Released on J-STAGE: July 18, 2008
    DOIhttps://doi.org/10.5795/jjscc.46.1
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Objectives : In fine needle aspiration cytology for thyroid cancer, it is difficult to discriminate the exact histological type between medullary and papillary carcinoma.
    Study Design : Consecutive archives of thyroid tumor cases (total number 631) in last 10 years (1995-2004) were reviewed. We attempted to improve diagnostics by comparative cytological findings with electron microscopic features and by using immunocytochemical markers-calcitonin, chromogranin A, and CEA for 3 medullary carcinoma cases.
    Results : After decoloring conventional cytological stains, immunocytochemical stains worked well. Comparative electron microscopic and cytological study revealed plausible but not definitive small cytoplasmic granular structures and fine fibral substructures in the extracellular matrix.
    Conclusion : Careful observation of cytological specimens noting the cytological features of medullary carcinoma and the correlative interpretation of typical electron microscopic feature would reduce underestimation of the possibility of medullary carcinoma. Using single (calcitonin) but and a battery of three immunocytological markers—calcitonin, chromogranin A and CEA—would significantly improve diagnostic validity in medullary carcinoma.
    View full abstract
    Download PDF (663K)
  • Study on the cytology of the pancreatic duct by different sampling
    Yoshiki NAITO, Yoshinobu OKABE, Akihiko KAWAHARA, Tomoki TAIRA, Hirono ...
    2007 Volume 46 Issue 1 Pages 7-11
    Published: January 22, 2007
    Released on J-STAGE: July 18, 2008
    DOIhttps://doi.org/10.5795/jjscc.46.7
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Objective : We evaluated the diagnostic cytological usefulness of different methods of cancer cell collection in chromatin stainability.
    Study Design : Of patients diagnosed with ordinary pancreatic ductal carcinoma at Kurume University Hospital in January through December 2005, we studied 18 who had undergone endoscopic retrograde pancreatography (ERP), in which a cannula was inserted to the vicinity of the lesion, and allowed multiple collections of cells, providing 57 specimens. To collect specimens, we conducted pure pancreatic juice cytology (PPJC), pancreatic duct brush cytology (PBC), brush wash cytology (BWC), and pancreatic ductal lavage cytology (PLC). Chromatin stainability was expressed in chromatin smudging or condensation.
    Results : Chromatin smudging or condensation was observed in 54% (6/11) by PPJC, 43% (6/14) by PBC, 7% (1/14) by BWC, and 30% (3/10) by PLC. PPJC, BWC, and PWC resulted in chromatin condensation by digestive enzymes and PBC in chromatin smudging due to drying after smears were prepared.
    Conclusion : Different sampling produced different chromatin-staining patterns, and BWC has a high possibility of obtaining easily evaluated cancer cells.
    View full abstract
    Download PDF (322K)
  • Intraoperative imprint cytology in sentinel lymph node biopsy in patients with breast cancer
    Akemi IWAMOTO, Yasuaki HIROOKA, Yoshimi OZAKI, Shizue YOSHIOKA, Kaneno ...
    2007 Volume 46 Issue 1 Pages 12-16
    Published: January 22, 2007
    Released on J-STAGE: July 18, 2008
    DOIhttps://doi.org/10.5795/jjscc.46.12
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Objective : Breast cancer presents difficulties in intraoperatively diagnosing sentinel lymph node metastasis as positive or negative. We point out the usefulness of stump cytology in detecting metastasis in dissected sentinel nodes.
    Study Design : During surgery, 42 sentinel lymph nodes (SLNs) were obtained from 17 patients with N0 breast cancer operated on between 2003 and 2005. Each node was cut at 1.3 mm and imprinted onto glass slides, followed by Papanicolaou and immunocytochemical staining using CEA and CK19. Half of the SLNs were evaluated by HE staining and half by RT-PCR using CEA and CK19 probes.
    Questionnaires on how to detect positive SLNs during surgery were distributed to San-in district hospitals.
    Results : Cancer metastasis was detected in 5 of 42 SLNs in HE staining. The sensitivity of intraoperative frozen sections was 60% and stump cytology and RP-PCR 100%. Accuracy for frozen sections was 95.3% and stump cytology and RT-PCR 100%.
    Intraoperative rapid histological diagnosis was possible at 3 hospitals and intraoperative rapid stump cytological diagnosis at 10.
    Conclusion : Stump cytological diagnosis is useful in detecting cancer cells in SLNs intraoperatively.
    View full abstract
    Download PDF (278K)
    • |<
    • <
    • 1
    • >
    • >|
feedback
 Top