We report a typical extraskeletal myxoid chondrosarcoma (EMC) case and its histological, cytological, immunohistchemical, and cytogenetic findings. Histologically, the tumor was nodular, defined by fibrous septa filled with pale blue myxoid or chondromyxoid substance. Imprint cytology specimens contained abundant myxoid stroma with dispersed small, round to oval tumor cells. Some cells had coffee−been−like nuclear grooves. In cell block materials, tumor cells were immunopositive for S-100 protein. Cytogenetically, reciprocal translocation t (9 ; 17) (q22 ; q11) was detected. Our findings suggest that cytology could detect EMC.
Liquid-based cytology (LBC) has the potential for multipurpose applications. We have evaluated fixatives in an application to fluorescence in situ hybridization (FISH). Fixatives containing methanol produced excellent hybridization signals even in specimens preserved over 3 months, but others did not. We concluded that LBC fixative selection is critical in FISH applications.