We report a case of large cell neuroendocrine carcinoma, which is rare and difficult to diagnose using cytology alone. A 57-year-old woman suspected of having invasive endometrial carcinoma with peritoneal dissemination found at laparotomy underwent total hysterectomy and bilateral salpingo-oophorectomy. An enlarged residual tumor, massive pleural effusion, and ascites subsequently appeared, however, and the woman died three months later. Preoperative endometrial cytology showed clusters of atypical cells with large nuclei and few prominent nucleoli. Histology showed loosely arranged cohesive solid patterns. Immunohistology findings were positive for CD56, synaptophysin, and NSE. The possibility of large cell neuroendocrine carcinoma should thus be considered in the differential diagnosis of cytomorphologically poorly differentiated lesions.
We report a case of extramammary breast carcinoma of the axilla, diagnosed by (FNA) cytology. A 61-year-old woman with a left axillar mass was found in cytological specimens to have numerous ductal epithelial cells mixed with myoepithelial cells. Three years later, cytology from the ipsilateral axillar lesion showed higher cellularity. Papillary cell clusters consist of large atypical cells with coarse chromatin. The axillary tumor appeared to be extramammary breast carcinoma, confirmed by the prior diagnosis of the extrammary breast.
We report immunohistochemical mucin features in a case of intraductal papillary mucinous adenoma (IPMA). Tumor cells were positive for MUC2, CDX-2, MUC5AC, and human gastric mucin but negative for MUC1 and M-GGMC-1. Immunocytochemical mucin-marker analysis proved useful in IPMN subtyping.