We report a case of pulmonary coccidioidomycosis. A 24-year-old American man living in Arizona was found in X-ray imaging and computed tomography (CT) to have an about 20 mm coin-sized right-lung lesion, although specifics were not provided in bronchoscopy. Pulmonary resection yielded a rapid perioperative cytological diagnosis and a frozen tissue specimen. An orange-stained spherule was noted in the cytological specimen. Fluorescent staining readily detected the spherule, including an endospore. Note that communication with the clinician is required in such rare cases to obtain important clinical information beforehand.
We report a rare case of primary mammary malignant fibrous histiocytoma (MFH). A 57-year-old woman was found in aspiration cytology to have a cluster of markedly pleomorphic tumor cells, consisting of atypical fibroblastic and histiocytic cells, in a right breast mass, together with giant cells with bizarre nuclei and inflammatory cells. Histopathologically, tumor cells showed storiform pattern and were immunohistochemically positive for vimentin, KP-1, and α1-antitrypsin, yielding an MFH diagnosis. Cytological findings were thus found useful in diagnosing primary mammary MFH.
We report a case of thymic well-differentiated neuroendocrine carcinoma (atypical carcinoid) in a 68-year-old woman. Intraoperative tumor touch smear results showed loose aggregates of epithelial cells with rich cytoplasm. These cells had variably-sized round to oval nuclei accompanying “salt and pepper” chromatin. Although no necrosis was found, a few mitotic figures were observed. We diagnosed the lesion cytologically as thymic well-differentiated neuroendocrine carcinoma (atypical carcinoid). Immunocytochemical results showed tumor cells to be positive for synaptophysin. This report highlights the need for carefully observing mitotic figures when diagnosing thymic carcinoid.