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Volume 50 (2011)
- Issue 6 Pages 313-
- Issue 5 Pages 255-
- Issue 4 Pages 209-
- Issue 3 Pages 147-
- Issue 2 Pages 89-
- Issue 1 Pages 1-
Volume 50, Issue 4
Displaying 1-8 of 8 articles from this issue
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Original Article
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Masaki NAKA, Fumihiko OHKUBO, Sumiko WATANABE, Sadafumi TAMIYA, Tsuneh ...2011 Volume 50 Issue 4 Pages 209-213
Published: 2011
Released on J-STAGE: September 27, 2011
JOURNAL FREE ACCESSObjective : Reportedly, fiber cells are one of the most important cytological findings for uterine cervical squamous cell carcinoma. The aim of this study was to clarify the significance of fiber cells in uterine cervical squamous lesions (precancerous lesions and carcinoma).
Study Design : We analyzed 40 cervical smears including 10 cases consisting of four tissue-types (severe dysplasia, carcinoma in situ [CIS], invasive squamous cell carcinoma [SCC] stageI, and SCC stageII). The numbers of fiber cells were counted and compared among the different tissue-types. The diameters of cells and nuclei of the fiber cells were measured and compared with the degree of invasion.
Results : Fiber cells were observed in all the cases. We found that the numbers, size, and length-to-breadth ratio of the fiber cells were correlated with the degree of invasion.
Conclusion : Our results showed that the analysis of fiber cells is useful for the diagnosis of uterine cervical squamous neoplasia.View full abstractDownload PDF (402K)
Clinical Articles
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Hiroshi NISHIYAMA, Takeharu OOZEKI, Shu SOEDA, Takafumi WATANABE, Hide ...2011 Volume 50 Issue 4 Pages 214-219
Published: 2011
Released on J-STAGE: September 27, 2011
JOURNAL FREE ACCESSBackground : Clear cell adenocarcinoma of the uterine cervix is a rare condition and its prognosis is poor. We report herein a case of clear cell adenocarcinoma of the uterine cervix arising in a young woman without intercourse.
Case : A 34-year-old woman without intercourse exhibited atypical genital bleeding. Magnetic resonance imaging (MRI) showed a tumor in the vaginal cavity, approximately 8 cm in size, protruding from the uterine cervix. On cytologic examination of the tumor surface, we noted scattered large tumor cells with naked nuclei, prominent nucleoli and small clusters with finely abundant cytoplasm. Some hobnail-like cells were also noted. Hisotologic findings of biopsy specimens confirmed clear cell adenocarcinoma with solid nests, and tubular and microcystic structures. Although the patient underwent surgery and adjuvant chemotherapy, the disease continued to progress.
Conclusion : Although uterine cervical cancer is associated with infection by human papilloma virus, we should be aware of this rare histological type. When a woman without intercourse exhibits atypical genital bleeding, a gynecologic examination should generally be performed.View full abstractDownload PDF (1108K) -
Hiroshi NOGUCHI, Fumio HANAMURE, Tomoko SUEKAWA, Shinya SATO, Yuichiro ...2011 Volume 50 Issue 4 Pages 220-225
Published: 2011
Released on J-STAGE: September 27, 2011
JOURNAL FREE ACCESSBackground : We report a case of primary effusion lymphoma (PEL) without human herpes virus 8 infection (HHV-8) diagnosed by analyzing pericardial fluid.
Case : A 40-year-old HIV-seronegative man admitted for dyspnea and heart failure was found in echocardiography and chest X-ray imaging to have massive pericardial fluid necessitating pericardial drainage. Cytological pericardial fluid findings included large numbers of atypically large lymphocytes with irregular nuclei and distinct nucleoli. Multinucleated giant cells were also noted. Immunocytochemically, these atypical lymphoid cells were positive for CD20 and CD79a but negative for CD30 and CD38. Cells were negative for HHV-8 in polymerase chain reaction (PCR) and Epstein-Barr virus (EBV) in in-situ hybridization. The definitive diagnosis was PEL.
Conclusion : PEL is found mostly in HHV-8-positive subjects but rarely in those who are HHV-8-negative. Immunocytochemical staining and cell blocks are useful in diagnosing PEL.View full abstractDownload PDF (822K) -
Nozomi TAKABATAKE, Yuichi KINOSHITA, Shiho MATSUNAGA, Kazuo ICHIBE, Ya ...2011 Volume 50 Issue 4 Pages 226-230
Published: 2011
Released on J-STAGE: September 27, 2011
JOURNAL FREE ACCESSBackground : Distant sarcomatoid pleural malignant mesothelioma (SPMM) metastasis is rare. We report a very rare case of SPMM involving scalp metastasis.
Case : A 50-year-old man with a history of asbestos exposure seen for a rapidly growing scalp tumor was found in chest computed tomography (CT) to have irregular bilateral pleura thickening. Cytologically, needle-biopsy washing contained large numbers of small and large tumor cell clusters against a clean background. Histologically, tumor cells showed pleomorphism with sarcomatoid proliferation and were positive for multiple mesothelioma markers. In an autopsy conducted after the man died 2 months after the first medical examination confirmed that the scalp tumor involved SPMM metastasis.
Conclusion : Cytological examination alone may not enable SPMM to be definitively diagnosed, making it necessary to consideration findings such as clinical information, imaging features, histological findings, and immunohistochemistry.View full abstractDownload PDF (1038K) -
Kanae NOSAKA, Kohei SHOMORI, Manabu UDAGAWA, Hisao ITO2011 Volume 50 Issue 4 Pages 231-234
Published: 2011
Released on J-STAGE: September 27, 2011
JOURNAL FREE ACCESSBackground : Invasive histiocytoid-like lobular carcinoma (HLC) is often misdiagnosed as a benign lesion such as xanthogranuloma or a granular cell tumor. We report a case of invasive HLC in which we compared cytology and frozen section findings.
Case : A woman in her 80s hospitalized for a bilateral breast tumors had the left tumor diagnosed as invasive ductal carcinoma. On cytological examination, the right tumor had cells with plentiful granular cytoplasm and bland nuclei with a few small nucleoli scattered against a clear background. Paraffin-embedded sections showed “Indian-file” invasion patterns and intracytoplasmic lumen unclear in frozen sections. These cells were positive for cytokeratin AE1/3 and cytokeratin 7 and negative for cytokeratin 20, S-100, CD68, and E-cadherin. The definitive tumor diagnosis was HLC. Comparison of xanthogranuloma and granular cell tumors in frozen sections yielded indistinguishable lesions. In cytology, however, xanthogranuloma had an inflammatory background and the granular cell tumor showed extracytoplasmic granules—findings not observed in invasive lobular carcinoma.
Conclusion : The possibility of invasive HLC should be considered when cells with plentiful granular cytoplasm are observed in cytological examination.View full abstractDownload PDF (544K) -
Masaru NAKAMURA, Mariko OGAWA, Masami FUKUDA, Kazuo GIBO, Junichi SAIT ...2011 Volume 50 Issue 4 Pages 235-239
Published: 2011
Released on J-STAGE: September 27, 2011
JOURNAL FREE ACCESSBackground : Clear cell ovarian borderline tumor is rare, reported mostly as adenofibroma. We report a case whose diagnosis could not be determined preoperatively, particularly for malignant potential.
Case : A 72-year-old woman found in a medical checkup to have an abdominal mass was not found in cervical or endometrial cytology to have a malignancy. Tumor marker CA125 was 192 U/ml. Magnetic resonance imaging (MRI) showed a solid right ovarian tumor with a low at T2-weighted signal, necessitating total abdominal hysterectomy and bilateral salpingo-oophorectomy. The tumor had a yellowish-white solid part and a cystic part. Imprint smear cytology showed atypical glandular cells with coarse chromatin clumping. Microscopic tumor examination showed clear cell borderline adenofibroma.
Conclusion : Imprint smear cytology may be useful in supplementarily confirming clear cell borderline adenofibroma diagnosis.View full abstractDownload PDF (774K)
Brief Notes
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Mitsuhiro TACHIBANA, Naoki OOISHI, Yumi HASHIMOTO, Tamae SONE, Tatsuo ...2011 Volume 50 Issue 4 Pages 240-241
Published: 2011
Released on J-STAGE: September 27, 2011
JOURNAL FREE ACCESSMammary carcinoma with multinucleated osteoclast-like giant cells (OCGCs), an uncommon neoplasm, features giant cells morphologically resembling osteoclasts. A 76-year-old woman noticing a left breast cystic mass was found in fine-needle aspiration cytology (FNAC) to have many atypical epithelial cells with OCGCs. Immunohistochemical studies indicated that OCGCs were of histiocytic origin. FNAC specimens make it easy to observe OCGCs, so FNAC becomes useful in diagnosing breast carcinomas with OCGCs.View full abstractDownload PDF (254K) -
Shogo TAJIMA, Hajime HORIUCHI2011 Volume 50 Issue 4 Pages 242-243
Published: 2011
Released on J-STAGE: September 27, 2011
JOURNAL FREE ACCESSWe report invasive lobular carcinoma with apocrine differentiation in a 51-year-old woman. Despite fine-needle aspiration cytology four times, a definite diagnosis was difficult because cells with apocrine differentiation and unequivocal atypia were consistently found each time. These cells appeared as cellular clusters in which dyshesion was commonly observed. Scattered single cells with apocrine differentiation were numerous. These findings show the high discohesion of lobular carcinoma and the diagnosis was histologically confirmed in surgical specimens. Cellular apocrine cell clusters therefore suggest neoplastic lesions with apocrine differentiation and high discohesion suggests lobular carcinoma.View full abstractDownload PDF (375K)
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