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Volume 52, Issue 1
Displaying 1-11 of 11 articles from this issue
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Original Articles
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Ryuichi TAKAMIZU, Akihiro MIMURA, Naoto TANIGAWA, Takahiko SAKUMA, Kiy ...2013 Volume 52 Issue 1 Pages 1-7
Published: 2013
Released on J-STAGE: March 13, 2013
JOURNAL FREE ACCESSBackground : Triple-negative (TN) breast cancer is immunohistochemically characterized as estrogen receptor-, progesterone receptor-, and HER2-negative. We conducted a detailed analysis of the cytologic characteristics of TN and basal-like (BL) breast cancer in an attempt to enable cytologic diagnosis of TN and BL breast cancer.
Study Design : A total of 54 cases of TN breast cancer were included in this study. Of these, 41 cases that were positive for either or both cytokeratin 5/6 and EGFR were regarded as BL breast cancer. A total of 20 cases of the luminal subtype and 10 cases of HER2-positive cancer were included. Specimens of these groups were extensively reviewed with respect to 13 morphologic factors.
Results : The tumor cells of TN/BL breast cancer appeared as scattered clusters, without gland formation, often associated with lymphocytes in a necrotic background. They had larger and naked nuclei, giant cells, and squamous metaplasia-like changes were also observed.
Conclusions : The cytologic findings of the TN and BL groups were almost similar. The differences in the cytologic findings between the TN/BL group and the HER2 group were minor, and meticulous observation was required to differentiate between the two. However, the above-mentioned cytologic characteristics of TN/BL breast cancer were useful for discriminating it from luminal-type breast cancer, which is the most frequently encountered type of invasive ductal carcinoma.View full abstractDownload PDF (559K) -
Hirofumi SAKAMOTO, Makiyo TAKENAKA, Kazuki USHIMARU, Takuji TANAKA2013 Volume 52 Issue 1 Pages 8-11
Published: 2013
Released on J-STAGE: March 13, 2013
JOURNAL FREE ACCESSObjective : We investigated the cytologic features of endometrial Liquid-Based Cytology (LBC).
Study Design : We investigated a total of 3440 smears prepared by the BD SurePathTM method. LBC smears examined included the proliferative phase of the endometrium and proliferative endometrial lesions including endometrioid adenocarcinomas.
Results : In general, the background of LBC smears was clear and there were scattered endometrial cells and sheet- or ground pipe-like clusters. Fiber-like clusters of endometrial stromal cells were present, but there were a few scattered stromal cells. In the case of atypical endometrial hyperplasia or more advanced lesions, cellular and/or nuclear atypia and abnormalities in cell polarity (“nuclear projection” image) were observed. No differences were observed among smears from clinics where different instruments were used for collecting endometrial cells.
Conclusions : In LBC endometrial smears, the glandular epithelium appeared as the background. When we could determine whether cell clusters were of epithelial or non-epithelial origin, we were able to establish the pathobiology of the lesion, if any. Our findings suggest that endometrial LBC might be useful in the cytological diagnosis of proliferative endometrial lesions.View full abstractDownload PDF (573K) -
Shigeru TSUCHIDA, Yoshimasa NAKAZATO, Satomi TABATA, Harumi KAMIYAMA, ...2013 Volume 52 Issue 1 Pages 12-16
Published: 2013
Released on J-STAGE: March 13, 2013
JOURNAL FREE ACCESSObjectives : For samples expected to be dried during preparation, a method to prepare samples with a high diagnostic value by employing rehydration was investigated.
Study Design : Impression preparations of tissues histologically diagnosed as adenocarcinoma were prepared. After drying, the preparations were rehydrated with saline or 10% skim milk, and the nuclear findings and area were investigated.
Results : The nuclei in cells after rehydration were slightly larger than those in the standard alcohol-fixed preparation, but close observation of the nuclei and cytoplasm was possible.
Conclusion : For samples likely to be dried during preparation, preparations with a high diagnostic value can be prepared by rehydration with saline after preparing dry samples.View full abstractDownload PDF (794K)
Clinical Articles
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Tomonori KOZAKAI, Kazuyo NISHIZAWA, Akiko ISHIDA, Keiji IIZUKA, Hiroyo ...2013 Volume 52 Issue 1 Pages 17-22
Published: 2013
Released on J-STAGE: March 13, 2013
JOURNAL FREE ACCESSBackground : Urothelial carcinoma (UC), plasmacytoid variant is a rare subtype of infiltrate urothelial carcinoma reported by Sahin et al. in 1991. This tumor is characterized by tumor cells that resemble plasma cells, and has a poor prognosis. We describe the cytologic and histologic findings, and clinical course of a case of UC, plasmacytoid variant, with peritoneal dissemination.
Case : A 72-years-old man presented with complaints of pollakiuria and dysuria. Cystoscopy indicated the edematous appearance of the bladder mucosa. Bladder washing cytology showed cellular features of UC, high grade. Transurethral resection of the bladder tumor revealed UC, plasmacytoid variant and carcinoma in situ. Ascites fluid cytology demonstrated peritoneal dissemination of the UC, plasmacytoid variant. Urine cytology showed both tumor cells of UC, high grade and UC, plasmacytoid variant.
Conclusion : The presence of atypical cells with plasmacytoid features in urinary specimens should be considered as the differential diagnosis of UC, plasmacytoid variant. Furthermore, ascites fluid cytology may play an important role in the diagnosis of UC, plasmacytoid variant, because of its frequent peritoneal spread.View full abstractDownload PDF (600K) -
—A case report—Hideo MATSUI, Masahiro FUJITA, Tetsuya KITAMURA, Shin RIN, Toshihiro S ...2013 Volume 52 Issue 1 Pages 23-27
Published: 2013
Released on J-STAGE: March 13, 2013
JOURNAL FREE ACCESSBackground : The canalicular adenoma is a rare benign salivary gland tumor of the oral cavity, typically located in the buccal mucosa of the upper lip. We report herein on a case of canalicular adenoma in the buccal mucosa of the upper lip assessed with a needle aspiration cytological study.
Case : An 84-year-old female had a non-ulcerated tumor measuring 20×10 mm in the buccal mucosa of the upper lip.
Conclusion : On the aspiration cytological study, most of the tumor cells appeared to be basal cell-like nuclear aggregate, and focally columnar tumor cells with oval nuclei were seen. The tumor cells had papillary and tubular patterns and focally they were arranged in string-like or bead-like structures. At first the cytological diagnosis pointed to a suspected basal cell adenoma, whereas the histopathological diagnosis was canalicular adenoma. Then we carefully assessed the tumor taking both the cytological and histopathological appearances into consideration.
The final cytological diagnosis was canalicular adenoma, but a differential diagnosis had to be made between basal adenoma and adenoid cystic carcinoma.View full abstractDownload PDF (567K) -
Shigeru TSUCHIDA, Masaru KOJIMA, Hiromi MACHIDA, Harumi KAMIYAMA, Yosh ...2013 Volume 52 Issue 1 Pages 28-31
Published: 2013
Released on J-STAGE: March 13, 2013
JOURNAL FREE ACCESSBackground : Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) may be accompanied by epithelioid cells. We herein report on a case of MALT lymphoma with many epithelioid cells.
Case : A 76-year-old male with an abnormal shadow in the right upper lobe visited our hospital. Positron emission tomography/computed tomography revealed a moderate accumulation of 18F-fluorodeoxyglucose. Transbronchial needle aspiration cytology was positive for lymphocytes and plasmacytoid cells, mixed with ciliated columnar epithelial cells and many epithelioid cells. Histology was positive for lymphoepithelial lesions with many lymphocytes, plasmacytoid cells, and epithelioid cells.
Conclusions : MALT lymphoma may be accompanied by many epithelioid cells. Thus, MALT lymphoma as well as sarcoidosis should be considered in patients with lymphocytes and many epithelioid cells in the lung.View full abstractDownload PDF (792K) -
Mari NARITOMI, Sakae HATA, Minako FUKUYA, Takuo KANAHARA, Naoki KANOMA ...2013 Volume 52 Issue 1 Pages 32-35
Published: 2013
Released on J-STAGE: March 13, 2013
JOURNAL FREE ACCESSBackground : We report herein on a case of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) arising from the kidney.
Case : A 59-year-old woman. An imprint cytology renal biopsy specimen consisted of mainly small lymphocytes and plasma cells with little cytologic atypia. The polymerase chain reaction technique for IgH gene re-arrangement was required for the diagnosis.
Conclusion : Atypical lymphocytes is weak, cytology was struggling to find a diagnosis. We need to reference as well as the clinical findings and imaging findings, make a careful diagnosis.View full abstractDownload PDF (546K) -
Hideyuki ABE, Akihiko KAWAHARA, Yasuo SUGITA, Tomohiko YAMAGUCHI, Tomo ...2013 Volume 52 Issue 1 Pages 36-40
Published: 2013
Released on J-STAGE: March 13, 2013
JOURNAL FREE ACCESSBackground : We report two cases demonstrating typical oligodendroglioma, focusing on the characteristic cytological features, and discuss the importance to OLIG2 expression and 1p19q deletions.
Case : Case 1 was 60-year-old female and case 2 was 60-year-old male, respectively. They complained of subjective symptoms, such as vertigo and convulsions, and a mass was found in the right parietal lobe of brain by magnetic resonance imaging. Squash smears showed a loose cluster of round tumor cells with scant cytoplasm in both cases 1 and 2. Although there were aggregates of capillary vessels, there were no mitotic figures or necrosis. The nuclei of tumor cells were irregular with small inconspicuous nucleoli and fine chromatin patterns. Histologically, tumors appeared monotonous with clear cytoplasm and capillary vessels. There were no mitotic figures, necrosis or endothelial proliferation in the tumor. On immunohistochemistry, the tumor expressed OLIG2 protein and showed a low Ki-67 labeling index. Furthermore, 1p19q deletions were identified in both cases 1 and 2 by fluorescence in situ hybridization.
Conclusion : Diagnosis of oligodendroglioma requires differentiation from other brain tumors demonstrating small round cells. Characteristic cytological findings of oligodendroglioma are round tumor cells with irregular nuclei and capillary vessels. Furthermore, detecting overexpression of OLIG2 and 1p19q deletions also contributes to the differential diagnosis from other brain tumors.View full abstractDownload PDF (563K)
Brief Notes
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Sachiko SEYAMA, Hidekazu KAYANO, Atsushi SASAKI, Masanori YASUDA, Mich ...2013 Volume 52 Issue 1 Pages 41-42
Published: 2013
Released on J-STAGE: March 13, 2013
JOURNAL FREE ACCESSWe report herein on a case of cervical spinal meningioma in a 29-year-old woman, which presented as a subcutaneous mass of the neck, and fine needle aspiration cytology was performed. Cytological analysis revealed spindle cells in loose clusters or syncytial arrangements. The nuclei were ovoid with finely granular, evenly distributed chromatin. Nucleoli were inconspicuous, and intranuclear cytoplasmic invaginations were noted. The diagnosis of meningioma was histologically confirmed in the surgical specimens. Although uncommon, meningioma should be considered in the differential diagnosis of any tumor in the neck.View full abstractDownload PDF (425K) -
Tadaaki MOCHINO, Shuuich KAYANO, Atsushi SASAKI, Michio SIMIZU2013 Volume 52 Issue 1 Pages 43-44
Published: 2013
Released on J-STAGE: March 13, 2013
JOURNAL FREE ACCESSWe report on a case of recurrent meningioma located in the left parietal region in a 47-year-old man. A smear/crush preparation obtained at the intraoperative consultation showed not only typical features of meningioma such as whorl formation and intranuclear cytoplasmic inclusions, but also an unusual cytomorphologic feature of a few mitoses. The diagnosis of atypical meningioma was established by the results of the histological and immunohistochemical stainings of the permanent sections. The present case indicated that cytology of smear preparations is useful in arriving at the final diagnosis of atypical meningioma.View full abstractDownload PDF (369K) -
—a report of case—Dai ISHII, Akira IYODA, Hirokuni KAKINUMA, Makoto SAEGUSA, Yukitoshi S ...2013 Volume 52 Issue 1 Pages 45-46
Published: 2013
Released on J-STAGE: March 13, 2013
JOURNAL FREE ACCESSWe here report a case of Pulmonary Langerhans cell histiocytosis (PLCH) diagnosed by imprint cytology obtained from thoracoscopic biopsy. Intraoperative tumor imprint smears showed Langerhans cells in a background with eosonophils, macrophage, and lymphocytes. Langerhans cell having noched nuclei and abundant cytoplasm with pseudopodia-like projections. The differentiation of Langerhans cells are epithelioid cells or the cells derive from epithelioid hemangioendothelioma. Langerhans cell can diagnose through the above remarks. In our case since the diagnosis of PLCH was made based upon characteristic cytological findings, cytology was useful in diagnosing PLCH.View full abstractDownload PDF (423K)
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