Making a cytologic diagnosis of basal cell adenocarcinoma (BCAC) of the salivary gland is difficult due to the similarity of its morphologic features to other benign and malignant tumors of the salivary glands. Morphometric analysis revealed that the average minimum diameter of the nuclei of BCAC was significantly wider than that of basal cell adenoma (BCA). BCAC was associated with a higher nuclear circularity compared with BCA. Our case report shows that roundness of the nuclei, formation of a palisading pattern, and presence of a basement membrane-like material in fine-needle aspiration specimens could lead to a specific diagnosis of BCAC.
We report herein on a case of cutaneous apocrine carcinoma, a rare malignant tumor of the skin, arising in the axilla of a 72-year-old female. Aspiration cytology showed tumor cells with abundant cytoplasm and decapitation secretion, arranged in papillary, tubular and solid patterns. Although cytological atypia was weak, the lack of myoepithelial cells and the presence of pair cells suggested malignancy. In this case, it was difficult to determine the presence or absence of malignancy, since the tumor was a well differentiated type (low grade) as shown by the histopathological findings.
We report herein on a case of spontaneous perforation of the esophagus (Boerhaave’s syndrome) in a 61-year-old man. The pleural effusion specimen was a dirty dark brown liquid and the cytological findings showed scattered orangeophilic superficial or intermediate squamous epithelial cells without atypia as well as bacteria and food in the inflamed pleural effusion. These findings indicated the possibility of an esophageal perforation. Quick diagnosis may improve the survival rate of this disease. Both pathologists and cytologists should pay close attention to dirty black pleural effusion which contains superficial or intermediate squamous cells without atypia.
We examined how to improve the cell recovery for cell block preparations using cervical liquid-based cytology (LBC) samples. Forty cases of both NILM and LSIL, respectively, were split into three groups and three different cell block preparation methods were applied such as nylon mesh, OCT compound and cotton. The total cell number (isolated cells and cells in cell clusters) and the incidence of cases with large clusters (≥50 cells) in specimens were counted. We found that the cotton method, by which clusters were significantly recovered, was better than the others. The cotton method is a useful tool for cell recovery in block preparations from LBC samples.
We report herein on a case of prostatic duct adenocarcinoma in a 74-year-old man, who presented with urinary retention. A cytology specimen obtained by catheterization showed loose clusters or aggregates composed of small round to oval cells. These cells revealed fine chromatin with prominent nucleoli. A TUR-P specimen revealed adenocarcinoma with a papillary pattern. The immunohistochemical analysis revealed that these tumor cells were positive for PSA and PAP. Although it is rare, prostatic duct adenocarcinoma cells can be observed in urine specimens, therefore it should be kept in mind as a differential diagnosis. In addition, immunohistochemistry may be useful for such differential diagnoses.