We report a case of pigmented villonodular synovitis (PVNS) of the knee diagnosed in a 69-year-old woman. The fine-needle aspiration smear of the joint fluid showed loose aggregates of mononuclear cells relatively rich in cytoplasm with bland nuclei containing a single nucleolus. Hemosiderin-containing cells and multinucleated cells were also observed. Histopathological study of the resected synovial tumor confirmed the diagnosis of PVNS. The characteristic cytological features of PVNS are as follows : i) aggregates of bland mononuclear cells, and ii) presence of hemosiderin-containing mononuclear cells and multinucleated cells. Recognition of these features can facilitate the cytodiagnosis of PVNS.
We report a case of hidradenoma papilliferum of the vulva. A 70-year-old woman was admitted to our hospital with a vulvar tumor. Cytologic smear examination revealed seat-shaped tumor cells. The nuclei contained uniformly distributed fine granular chromatin. Around the seat, cells with thin concentrated chromatin were detected. Subsequently, local excision was performed. Histological findings of the resected specimen showed that the tumor was composed of cells organized in tubular and papillary structures. The tumor contained epithelial cells with apical snouts and p63-positive myoepithelial cells were observed on immunostaining. Apocrine metaplasia was detected. No mitotic figures or atypical nuclei were observed.
Cytologic diagnosis of malignant lymphoma of the uterine cervix is difficult, because the malignant cells usually proliferate under the epithelium. However, the existence of erosion may help to diagnose malignant lymphoma of the uterine cervix. A middle-aged woman visited our hospital with a history of genital bleeding. Colposcopy revealed obvious redness on the upper lip of the uterine cervix, suggesting the existence of erosion. Cytologic examination revealed atypical cells in a background of inflammatory cell infiltration with erosion. Histological and immunohistochemical examination revealed diffuse large B-cell lymphoma. This case served to underscore the significance of the erosion of the uterine cervix in the diagnosis of malignant lymphoma.