A 61-year-old man underwent distal gastrectomy for gastric cancer. Two years after the surgery, chest CT revealed a nodular lesion in the lung. Lobectomy was performed because primary lung cancer was suspected by the preoperative cytology. Finally, histopathologial examination of the resected specimen revealed the nodule as a metastasis from gastric cancer. The tumor stump cytology showed a necrotic background and cell clusters with three-dimensional tubular structures. The nuclei showed a coarsely granular chromatin pattern with prominent nucleoli. Moreover, the nuclei also showed focal TTF-1 immunoexpression. Diagnostic approaches combining cytology and clinical information are advisable to improve the yield for accurate diagnosis of pulmonary malignancies.
We report the case of a female patient in her 70’s with poorly differentiated carcinoma of the thyroid gland. Fine needle aspiration cytology showed epithelial clusters with irregular nuclear margins and nuclear grooves, as well as intracytoplasmic lumina formation. Whole-body imaging revealed no tumorous lesions in any anatomic site other than the thyroid gland. Cytologists should recognize that intracytoplasmic lumina may be observed in neoplastic lesions of thyroid gland.