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[in Japanese]

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Aim:There has been no assessment of the efficacy of prokinetics on the use of semi-solid enteral nutrients. The aim of this study was to investigate the actions of prokinetics by using a different properties of the test meal.
Methods:The ¹³C breath test was performed by giving the following test meals to 5 healthy volunteers. Liquid meal or semi-solid meal with a total calorific value of 225 kcal were used. Doses of 5 mg of mosapride citrate were orally administered with water at 22:00 on the day before and at 08:00 on the day of the test. Then liquid meal containing 100 mg of ¹³C-acetate Na salt was ingested at 08:50. After an interval of one week, water was taken as a control. The same method was used for evaluation of semi-solid meal.
Expired air was sampled before and after ingestion of each test meal. ¹³CO₂ was excreted in the breath was measured to assess gastric emptying. Results:For the semi-solid meal, gastric emptying was significantly accelerated by the administration of mosapride citrate(P =0.0046).
Conclusion:The effect of gastrointestinal prokinetics on gastric emptying is more strongly demonstrated for semi-solid meal than for liquid meal.

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Effects of food polysaccharides were investigated on mechanical properties of liquid type nutritional foods to clarify the suitability as a thickener for enteral nutrition. Three representative commercial products of the same caloric value were used as a source of liquid type nutritional foods. Among polysaccharide samples tested, hybrid-carrageenan, xanthan gum, and a commercial mixture of these polysaccharides provided a rheological behavior typical to weak gel or structured liquid with the foods. Also, these polysaccharide samples were more effective than the others in lowering load in syringing the specimen (i.e., the foods thickened with polysaccharides) through an enteral tube and in reducing the amount of residue within the tube after syringing. Furthermore, these polysaccharide samples effectively increased shape retention and decreased fluidity of the food bolus exuded from the tube upon syringing. The commercial mixture enhanced viscosity the most rapidly, reaching to a pseudo-plateau state within a short time (i.e., ‹ 10 min). The mixture of hybrid-carrageenan and xanthan gum has proven to be the most favorable thickener for this purpose.

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[in Japanese]

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[in Japanese]

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[in Japanese]

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