The Journal of the Japan Society for Respiratory Endoscopy
Online ISSN : 2186-0149
Print ISSN : 0287-2137
ISSN-L : 0287-2137
Volume 27 , Issue 8
Showing 1-28 articles out of 28 articles from the selected issue
  • Type: Cover
    2005 Volume 27 Issue 8 Pages Cover1-
    Published: December 25, 2005
    Released: October 15, 2016
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  • Type: Cover
    2005 Volume 27 Issue 8 Pages Cover2-
    Published: December 25, 2005
    Released: October 15, 2016
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  • Type: Appendix
    2005 Volume 27 Issue 8 Pages App1-
    Published: December 25, 2005
    Released: October 15, 2016
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  • Type: Index
    2005 Volume 27 Issue 8 Pages Toc1-
    Published: December 25, 2005
    Released: October 15, 2016
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  • Type: Index
    2005 Volume 27 Issue 8 Pages Toc2-
    Published: December 25, 2005
    Released: October 15, 2016
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  • [in Japanese]
    Type: Article
    2005 Volume 27 Issue 8 Pages 559-
    Published: December 25, 2005
    Released: October 15, 2016
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  • Yoichi Watanabe, Keisuke Matsuo, Akihiko Tamaoki, Shinobu Hosokawa, Sh ...
    Type: Article
    2005 Volume 27 Issue 8 Pages 561-564
    Published: December 25, 2005
    Released: October 15, 2016
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    We analyzed our patients with airway stenosis due to advanced lung cancer treated by bronchial interventional approach. This technique includes laser coagulation and airway stenting etc. The aim of this study is to clarify the indication of the bronchial intervention and the role on the whole clinical course of these patients. The results of this study demonstrated that prognosis who had good performance status after stent placement, and to whom following radiotherapy or chemotherapy were done appeared better than the others. In majority of advanced lung cancer patients who were treated by airway stenting, early relief of dyspnea and subjective improvement of quality of life and prognosis were obtained after these procedures.
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  • Shigemi Ishikawa, Yuichirou Ozawa, Hiromichi Ito, Mitsuaki Sakai, Tats ...
    Type: Article
    2005 Volume 27 Issue 8 Pages 565-570
    Published: December 25, 2005
    Released: October 15, 2016
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    Early hilar squamous cell carcinoma can be treated with photodynamic therapy for the curative intent. On the other hand, airway symptom due to advanced or end-stage lung cancer can be relieved immediately by means of bronchoscopic procedure. Moreover airway stent maintains symptom free and the quality of life although primarily palliative. Thus interventional bronchoscopy is now playing an important and a unique role in the management of early and advanced stage lung cancer involving the central airway. Advances in technology and medical science will lead to further progress in this new discipline.
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  • Yuka Miyazu, Teruomi Miyazawa, Atsuko Ishida, Taeko Shirakawa, Nobuoki ...
    Type: Article
    2005 Volume 27 Issue 8 Pages 571-575
    Published: December 25, 2005
    Released: October 15, 2016
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    Most patients with centrally located lung cancers have been exposed to carcinogens in tobacco smoke and frequently develop subsequent primary and/or multicentric tumors. Autofluorescence bronchoscopy has increased the detection rate of subtle changes in mucosa and enhanced opportunities for curative endobronchial therapeutic strategies. High magnification bronchoscopy (XBF-D240HM, Olympus) is also a new instrument to detect micro vascular structure in the bronchial mucosa. We could observe increased vascular growth and a complex capillary network in the dysplastic bronchial epithelium, called angiogenic dysplasia. Histologically "normal" bronchial epithelia in smokers may sometimes express unphysiologically telomerase as a field, and such epithelia are likely susceptible to develop lung cancer. We propose that ectopic expressions of telomerase in bronchial epithelia may precede transformation in human lung cancer development and that detection of telomerase protein in no cancerous bronchial epithelia will become a useful marker in detecting high-risk patients for lung cancer development.
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  • Kyoko Nakanishi, Yoshinobu Ohsaki, Maki Kurihara, Shoko Nakao, Eri Toy ...
    Type: Article
    2005 Volume 27 Issue 8 Pages 576-579
    Published: December 25, 2005
    Released: October 15, 2016
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    Background. We performed photodynamic diagnosis (PDD) using an autoflurescence bronchoscopy (AFB) system (PDS-2000) to determine the area of LASER radiation in the photodynamic therapy (PDT) of central type lung cancer since 1999. We also used the AFB system in the follow-up study of the patients. Methods. Twelve patients underwent PDT using PDD between 1999 and 2004. We determined the complete response (CR) rate and the recurrence rate after the PDT. We compared these results with results of PDT between 1982 and 1993, when the AFB system was not available. Results. Thirty-three central type lung cancer lesions in 12 patients were treated with PDT using PDD. We made alterations in the methods of LASER radiation according to the findings of PDD in 14 lesions among these 33 lesions. CR rate was 88% and recurrence rate was 12%. The CR rate and the recurrence rate were better than those between 1982 and 1993. Six lesions were squamous cell carcinoma in 23 areas in which bright red fluorescence was observed with PDD. Five lesions of those 6 cancer lesions were successfully treated with PDT. Conclusion. Determination of LASER radiation field and detection of cancer lesion using PDD, and follow-up study using AFB probably improved results of PDT.
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  • Shinji Sasada, Teruaki Nagano, Satoshi Koumo, Yasushi Otani, Naoko Kit ...
    Type: Article
    2005 Volume 27 Issue 8 Pages 580-587
    Published: December 25, 2005
    Released: October 15, 2016
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    Objectives. To evaluate the usefulness of the tissue biopsy used by Sasada transbronchial angled forceps (STAF) in patients with peripheral pulmonary lesions (PPL) which are difficult to reach with standard forceps. Methods. We have invented the STAF, a forceps with an angled tip. And we invented curve-shaped transbronchial biopsy (CS-TBB) using STAF to obtain adequate amounts of tissue. One hundred ten patients with PPL that were difficult to reach with standard forceps were evaluated. The patients first underwent bronchoscopy with a standard forceps and then with STAF. The specimens obtained with STAF and those obtained with standard forceps were separately fixed and analyzed. We compared the histological diagnosis of the specimens obtained by STAF with that of the specimens obtained with standard forceps. Statistical significance was calculated with McNemar X^2 statistic. Results. The diagnostic yield of all lesions from the specimens obtained with STAF (86 of 110 lesions, 78.2%) was significantly higher than that of lesions from the specimens obtained with standard forceps (43 of 110 lesions, 39.1%)[P<0.001]. Among malignant lesions, the yield obtained with STAF (60 of 72 lesions, 83.3%) was significantly higher than that obtained with standard forceps (32 of 72 lesions, 44.4%)[p<0.001]. Among benign lesions, the yield obtained with STAF (26 of 38 lesions, 68.4%) was also significantly higher than that obtained with standard forceps (11 of 38 lesions, 28.9%) [p<0.001]. Among the different lesion areas, the right upper lobe plus the left upper division gave the greatest difference in yield (STAF, 46 of 60 lesions, 76.7%; standard forceps, 22 of 60 lesions, 36.7%)[p<0.001]. Among the different size ranges, the diagnostic yields obtained with STAF were significantly higher than that obtained with standard forceps except the 10mm or less size range. There were two complications, pneumothorax and bronchial bleeding, both of which were controlled easily. Conclusions. STAF was shown to be useful for obtaining tissues for histological diagnosis from PPL which were difficult to reach with standard forceps.
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  • Fumihiro Asano, Yoshihiko Matsuno, Toshitaka Suzuki, Koichi Yamazaki, ...
    Type: Article
    2005 Volume 27 Issue 8 Pages 588-591
    Published: December 25, 2005
    Released: October 15, 2016
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    In bronchoscopic examination for pulmonary peripheral lesions, we previously proposed virtual bronchoscopic navigation (VBN) in which a bronchoscope is guided to the lesion under direct vision using virtual images on the route to the lesion. In this study, the results of VBN in respiratory endoscopic treatment are reported, and its problems and solution methods are discussed. The results of VBN were reported in terms of : 1) application to CT-guided ultrathin bronchoscopy and navigation accuracy, 2) production of virtual images using the pulmonary artery, and 3) application to marking before thoracoscopic surgery. The advantages of VBN were simple guidance of the bronchoscope that can be performed by anyone and shortening of the examination time. The problems of VBN were : 1) the rotation procedure of the bronchoscope can not be expected, 2) skills are necessary for the production of virtual images, 3) the diagnosis rate is low for lesions in which the involved bronchi and blood vessels are unknown, and 4) the method of confirming arrival at the lesion and the selection of a bronchoscope are problems. To solve these problems, we are developing a navigation system and combine VBN with endobronchial ultrasonography using a guide sheath. VBN may be a promising assistance method for bronchoscopy of pulmonary peripheral lesions.
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  • Kiyoshi Shibuya, Masako Chiyo, Takahiro Nakajima, Kazuhiro Yasufuku, E ...
    Type: Article
    2005 Volume 27 Issue 8 Pages 592-595
    Published: December 25, 2005
    Released: October 15, 2016
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  • Noriaki Kurimoto, Hiroaki Osada, Teruomi Miyazawa, Yuka Miyazu, Atsuko ...
    Type: Article
    2005 Volume 27 Issue 8 Pages 596-602
    Published: December 25, 2005
    Released: October 15, 2016
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  • Hiroshi Semba
    Type: Article
    2005 Volume 27 Issue 8 Pages 603-605
    Published: December 25, 2005
    Released: October 15, 2016
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  • Masazumi Watanabe, Akitoshi Ishizaka, Naoki Hasegawa, Hidetoshi Nakamu ...
    Type: Article
    2005 Volume 27 Issue 8 Pages 606-610
    Published: December 25, 2005
    Released: October 15, 2016
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    Bronchoalveolar lavage method that is relatively invasive to patients has been using for analysis of various pulmonary pathological conditions. We have developed a new, less invasive bronchoscopic microsampling (BMS) probe to measure the concentration of biochemical substances, including cytokines and tumor markers, in epithelial lining fluid (ELF). ELF can be collected absorbing to BMS probe tip by this method. We tried to use BMS method for various conditions describing below. 1) Increasing levels of neutrophil elastase, IL-6, VEGF and KL-6 in ELF in ARDS patients were shown. KL-6 values at onset was a prognostic factor of ARDS. 2) CYFRA and CEA values in ELF from tumor surrounding part were higher than from contralateral side. ROC analysis showed CYFRA is a suitable tumor marker. 3) Clarithromycin concentration in ELF can be measured in Mycobacterium avium complex patients. 4) We also developed a smaller BMS probe for rat experiment. High TNF-alpha level in ELF was detected in rat lung injury model induced by LPS. 5) ELF covered by BMS method was available for proteomic analysis using proteintip system^<TM>. BMS method was a useful and powerful tool to analyze various pulmonary pathological conditions.
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  • Hirohiko Ikura, Kenji Shimizu, Teruhito Mochizuki
    Type: Article
    2005 Volume 27 Issue 8 Pages 611-616
    Published: December 25, 2005
    Released: October 15, 2016
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    Morphological remodeling is induced in the course of many chronic lung diseases and changes the gas kinetics in lung periphery. Therefore, respiratory failure is caused by remodeling. Some previous studies showed that ultra-high-resolution CT (UHRCT) demonstrates alveolar walls clearly and can show the peripheral lung structure in three-dimensional (3-D) with non-invasive imaging. The synchrotron radiation CT (SRCT) and the micro focus X-ray CT (MFXCT) were used in our studies as UHRCT. SRCT images were obtained by a SRCT system constructed in SPring-8 (Hyogo, Japan). On the other hands, MFXCT is featured by cone-beam X-ray, and has been used as industrial CT for quality and security check. In normal lung, alveolar wall can be visualized with approximately 10-μm of spatial resolution using UHRCT. Additionally, UHRCT can provide 3-D information of lung periphery of an inflated and fixed lung specimen that keeps inflation like in vivo. In pulmonary fibrosis, the gas-exchanging area is definitely decreased due to the traction dilatation. In addition, it is assumed that the compliance of peripheral airway is decreased due to surrounding fibrosis. In emphysema, UHRCT demonstrates that the peripheral airways and airspaces beyond respiratory bronchioles were dilated and destroyed. It showed peripheral remodeling of emphysematous change on a microscopic level. The peripheral bronchioles were narrower than those in normal. It suggested that the peripheral check-valve mechanism worked in those peripheral airways. Ultra high-resolution CT can clearly demonstrate the peripheral normal structure and the remodeling in chronic lung disease at microscopic level. It would be useful to verify the morphologic corroboration of pathophysiology in lung periphery.
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  • Kazuyoshi Suga
    Type: Article
    2005 Volume 27 Issue 8 Pages 617-625
    Published: December 25, 2005
    Released: October 15, 2016
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  • Akio Niimi, Tetsuya Ueda, Hisako Matsumoto, Toyohiro Hirai, Michiaki M ...
    Type: Article
    2005 Volume 27 Issue 8 Pages 626-629
    Published: December 25, 2005
    Released: October 15, 2016
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  • Soichiro Kanoh, Hideo Kobayashi, Chikatoshi Sugimoto, Yu Hara, Kazuo M ...
    Type: Article
    2005 Volume 27 Issue 8 Pages 630-632
    Published: December 25, 2005
    Released: October 15, 2016
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  • Type: Appendix
    2005 Volume 27 Issue 8 Pages App2-
    Published: December 25, 2005
    Released: October 15, 2016
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  • Type: Appendix
    2005 Volume 27 Issue 8 Pages App3-
    Published: December 25, 2005
    Released: October 15, 2016
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  • Type: Index
    2005 Volume 27 Issue 8 Pages _-1_-_-3_
    Published: December 25, 2005
    Released: October 15, 2016
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  • Type: Index
    2005 Volume 27 Issue 8 Pages _-4_-_-9_
    Published: December 25, 2005
    Released: October 15, 2016
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  • Type: Index
    2005 Volume 27 Issue 8 Pages 1-3
    Published: December 25, 2005
    Released: October 15, 2016
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  • Type: Index
    2005 Volume 27 Issue 8 Pages 4-7
    Published: December 25, 2005
    Released: October 15, 2016
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  • Type: Index
    2005 Volume 27 Issue 8 Pages 8-11
    Published: December 25, 2005
    Released: October 15, 2016
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  • Type: Cover
    2005 Volume 27 Issue 8 Pages Cover3-
    Published: December 25, 2005
    Released: October 15, 2016
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