Japanese Journal of Thrombosis and Hemostasis
Online ISSN : 1880-8808
Print ISSN : 0915-7441
ISSN-L : 0915-7441
Volume 10, Issue 6
Displaying 1-8 of 8 articles from this issue
  • Motokuni AOKI, Ryuichi MORISHITA
    1999 Volume 10 Issue 6 Pages 435-443
    Published: December 01, 1999
    Released on J-STAGE: August 05, 2010
    JOURNAL FREE ACCESS
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  • Megumi HOJO, Hiromitsu OHTSUKA, Yoshiki AIZAWA, Tetsuo OGIWARA
    1999 Volume 10 Issue 6 Pages 444-450
    Published: December 01, 1999
    Released on J-STAGE: August 05, 2010
    JOURNAL FREE ACCESS
    Castrated immature male and female rats were injected subcutaneously with sex hormones either estrogen or testosterone, and the concentration of vitamin K2 (menaquinone-4, MK-4) in the liver was compared. The level of liver MK-4 increased after injection of estrogen, but decreased after injection of testosterone regardless of the sexes of castrated rats. Although the amounts of estrogen given the animals were the same, the increase in the liver MK-4 was more distinct in males than in females, reflecting a sex-dependent sensitivity of the liver MK-4 to the level of estrogen (means: 9.68ng/g in females: 12.54ng/g in males at 6 weeks of age). When these animals were fed with vitamin K-deficient foods, females showed greater decreases in the liver MK-4 than males (means: from 13.62 to 1.86ng/g in females: 3.97 to 2.47ng/g in males). The female rats thus appear to be far more sensitive to vitamin K-deficiency for maintaining the level of liver MK-4. Although there still exists the species barrier regarding the level of liver MK-4, the data altogether seem to be relevant to the clinical consequence of osteoporosis as occures more frequently in postmenopausal women manifesting a rapid decrease in the estrogen level than in men at the same ages.
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  • Tsukasa ICHINO, Hidesaku ASAKURA, Keiji AOSHIMA, Masahide YAMAZAKI, Yu ...
    1999 Volume 10 Issue 6 Pages 451-456
    Published: December 01, 1999
    Released on J-STAGE: August 05, 2010
    JOURNAL FREE ACCESS
    Tissue factor (TF) and lipopolysaccharide (LPS) have been frequently used as inducers disseminated intravascular coagulation syndrome (DIC) in animals experimental models, but the consequences in the animals may not have been assesed from the view point of district entities. In this study, we have attempted to see their characteristic features in the pathophysiology of there two types of DIC models with special reference to selected hemostatic parameters and pathological findings in the kidney. To induce DIC, male Wistar rats were infused with either 3.75U/kg of TF over 1h or 30, 50 or 100mg/kg of LPS over 4h via the tail vein. Characteristis features for the TF-models were significantly elevated D dimer and thrombin-antithrombin III complex (TAT) with mild deposition of fibrin in the kidney. On the other hand, the LPS-infused rats manifested markedly decreased antithrombin III activity and severe fibrin deposition in the kidney. Since the pathological features of these two experimental DIC models are not identical, their experimental data and clinical implications ought to be carefully assessed as distinct entities.
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  • Yuji GOTO, Yoshihisa HAGIHARA
    1999 Volume 10 Issue 6 Pages 457-462
    Published: December 01, 1999
    Released on J-STAGE: August 05, 2010
    JOURNAL FREE ACCESS
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  • Toshiyuki MIYATA, Mayuko TAKEDA-SHITAKA, Hideaki UMEYAMA
    1999 Volume 10 Issue 6 Pages 463-468
    Published: December 01, 1999
    Released on J-STAGE: August 05, 2010
    JOURNAL FREE ACCESS
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  • Kenji FUKUTOME
    1999 Volume 10 Issue 6 Pages 469-473
    Published: December 01, 1999
    Released on J-STAGE: August 05, 2010
    JOURNAL FREE ACCESS
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  • Tatsuya ARAKI, Takayoshi HAMAMOTO, Jun MIZUGUCHI
    1999 Volume 10 Issue 6 Pages 474-478
    Published: December 01, 1999
    Released on J-STAGE: August 05, 2010
    JOURNAL FREE ACCESS
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  • [in Japanese]
    1999 Volume 10 Issue 6 Pages 479-480
    Published: December 01, 1999
    Released on J-STAGE: August 05, 2010
    JOURNAL FREE ACCESS
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