Objective: The impact of meteorological factors on human health is gaining attention. We previously reported that meteorological factors such as minimum temperature, diurnal temperature range (DTR), and average wind speed influence vasovagal reaction (VVR) onset in blood donors, particularly during apheresis. This study aimed to determine whether the meteorological conditions associated with VVR onset in Nara Prefecture vary according to donor attributes. Methods: We analyzed three-year meteorological data from the Nara Local Meteorological Observatory alongside donor attributes. Multivariate logistic regression was performed, stratifying by sex, age (young, 16–29; middle-aged, 30–49; older, 50–69 years), and physique (height, weight, and body mass index [BMI]; each dichotomized by the median). Results: Low wind speed increased VVR risk in older men and young women, while high DTR increased risk in middle-aged women. Furthermore, among women, high DTR was a risk factor for those with short stature, high weight, and high BMI, whereas low wind speed elevated risk in those with low weight and low BMI. Discussion: Meteorological susceptibility to VVR varies by donor attributes. These insights could facilitate the development of meteorological-based prediction models and targeted, personalized blood donor management strategies.