In spite of recent progress in blood transfusion, many caces of dangerous transfusions are being reported, and the need for elucidating the causes and management of such cases is an urgent problem. The authors have recently experienced a serious case of inccmpatible transfufion, 230 cc of group A blood to group O patient, due to the error in crossmatching, and the details of the symptoms which appeard in this patient are here reported.
1) The first sign was a copious hemorrhage, which may be regarded as the danger signal under general anesthesia, due to the depression in the prothrombin content of the blood.
2) Following the transfusion the agglutinin titer of the patient's serum showed a marked elevation.
3) Hepatic and renal disturbances were slight and transient.
4) The severity of the reactions following in-compatible transfusion appears to be influenced by the serum agglutinin titer of the recipient as well as by the extent to which the transfused erythrocytes are agglutinated, in addition to the amount of blood transfused.
5) Of the 34 cases of incompatible transfusion found in Japanese literatures, 19 were group O patients to whom 12 instances receiving group A bloods. This suggests that a special precaution must be taken when transfusing group A blood.
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