巻号一覧
14 巻, 3 号
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とくに血球荷電・溶血の面よりの考察後藤 幸生, 安中 寛, 竹下 鎮雄, 宮田 健1967 年 14 巻 3 号 p. 83-91
発行日: 1967/07/05
公開日: 2010/03/12
ジャーナル フリーOn the purpose to study the direct effects on red blood cells (R. B. C.) by several kinds of plasma expanders, experimental works about hemolysis and shift of electrical change of R. B. C. were performed, and the result was summarised as the followings:
1) As the results of prolongation of intravascular remain which is a common character of plasma expanders, the influences towards vascular and blood cells must be considered.
2) PH of plasma expanders have acidic tendency in general. (pH of Dextran is 4.5-Haemaccel is 6.8)
3) As to Dextran (mainly high molecular weight Dextran) and 5% glucose, the higher percentage of hemolysis are shown, but Haemaccel, amino acid solution show lower percentages, such as blood plasma, that have the protective effect on R. B. C.
4) Haemaccel etc. don't make any increase of the electrophoretic velocity of R. B. C. to the anode, as well as blood plasma, but LMW-Dextran makes some differences, namely increase of electronegativity. and electrical change of R. B. C. shows the reversible shift by the kind of solvent.
5) LMW-Dextran shows the highest relative suspension value. Mechanism of intravascular antisludging effect of LMW-Dextran depends on the electric repulsion caused by increase of electronegativity of R. B. C. as well as high suspension stability of blood.
6) Correlation among electrical charge, hemolysis and suspension stability of blood were showed, and these are the keys for the important problems on peripheral microcirculation.抄録全体を表示PDF形式でダウンロード (1243K) -
第1報 分画精製と物理化学的性状三浦 泰裕, 藤田 穣治, 山路 佳代子1967 年 14 巻 3 号 p. 92-99
発行日: 1967/07/05
公開日: 2010/03/12
ジャーナル フリーThe ceruloplasmin products from human plasma protein fraction IV-I have been compared with physicochemically and immunoserologically properties.
After the remove of water soluble proteins from fraction 1V-1 using by Cohn method, the DEAE-Cellulose or DEAE-Sephadex chromatography method was employed in purification studies.
The fractionation of the aceton extracted ceruloplasmin followed by an adsorption chromatography method using DEAE-Sephadex showed that purity of thus prepared products was quite high.
Also, the use of batch-type adsorpyion and elution with DEAE-Sephadex was more suitable procedure than colum chromatography and high speed centrifugation separation.
However, the crystalline human ceruloplasmin yielded by this method was still the complex under the investigation of ultracentrifuge analysis.
The immunoserological reactions of the crystalline ceruloplasmin with rabbit antibody to ceruloplasmin indicated that at least two antigens were present.抄録全体を表示PDF形式でダウンロード (7383K) -
とくに代用血漿使用後の変化について田中 右一1967 年 14 巻 3 号 p. 100-108
発行日: 1967/07/05
公開日: 2010/03/12
ジャーナル フリーThe variation of blood pressure after injecting 2ml/kg of body weight of blood rapidly into the aorta was recorded by electromanometer experimentally using mongrel dogs.
The curves were biphasic, and the ratios of the height of initial rise and the depth of late drop to the pulse pressure were calculated, and normal ranges were set separately.
Those ranges are valid over three hours' experiment in anesthetic condition.
After replacement of 20ml/kg of body weight of the blood by the same dose of several plasma-expanders, the injection of slowly aspirated own blood were repeated in every fifteen minutes, and the ratios were checked up to three hours.
Each expander was evaluated by the length of the time to keep those ratios in normal range. The saline and five per cent dextrose in water could keep those normal for only 30-60 minutes, but by using low molecular weight dextran, Haemacel, or Pan-amin D., the ratios remained within normal ranges up to 150 minutes.抄録全体を表示PDF形式でダウンロード (3547K) -
1967 年 14 巻 3 号 p. 109-120
発行日: 1967/07/05
公開日: 2010/03/12
ジャーナル フリーPDF形式でダウンロード (1685K)
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