日本輸血学会雑誌
Online ISSN : 1883-8383
Print ISSN : 0546-1448
ISSN-L : 0546-1448
21 巻, 4-6 号
選択された号の論文の4件中1~4を表示しています
  • 安田 純一, 七川 歓次, 新井 加余子
    1975 年 21 巻 4-6 号 p. 81-88
    発行日: 1975年
    公開日: 2010/03/12
    ジャーナル フリー
    Fifteen sera showing antiglobulin activity non-neutralizible by human γ-globulin, were found by screening with anti-D coated red cells, and characterized as follows:
    1) Only two out of fifteen sera exhibited no selectivity to various anti-D coated cells and can be included into “anti-antibody” defined by Milgrom. Remaining sera showed more or less selective reactivity either related or unrelated to allotypes of anti-D sera used.
    2) Red cells sensitized with human anti-bodies other than anti-D or merely coated with human γ-globulin were not agglutinated, or very weakly agglutinated by these sera.
    3) The antiglobulin activity of some of the sera was found to be neutralized, at least partially, by heat-treated human γ-globulin or by native rabbit γ-globulin.
    4) Antiglobulin activity to anti-D coated cells was considerably removed even by absorption with anti-D coated cells or with other sensitized cells which did not show strong agglutination by these sera.
    5) Agglutination titers of anti-D coated red cells and of sensitized sheep red cells were affected by absorption by homologous as well as by heterologous sensitized red cells.
    From the above results, it can be seen that the antiglobulin factor in these sera is non-neutralizible by syngeneic γ-globulin, yet cross-reacting to xenogeneic antibody.
    Antiglobulin activity to anti-D coated red cells in rheumatoid arthritis (R. A.) sera, on the contrary, can be analyzed into factors with single allotype specificity py absorption or neutralization procedures, and seems different from the non-neutralizible factor in this respect.
  • 榊原 欣作
    1975 年 21 巻 4-6 号 p. 89-98
    発行日: 1975年
    公開日: 2010/03/12
    ジャーナル フリー
  • 徳田 晴厚, 奥田 忠美, 村島 徳昭, 福井 弘, 中嶋 日出雄
    1975 年 21 巻 4-6 号 p. 99-102
    発行日: 1975年
    公開日: 2010/03/12
    ジャーナル フリー
    A case of acute gangrenous appendicitis in a adult patient with congenital factor XIII deficiency is reported.
    T. K., 40 years old male, had had repeated episodes of excessive bleeding from wound and muscular hematoma since his childhood. The diagnosis of congenital factor XIII deficiency was established at the Department of Pediatrics, Nara Medical University in 1966 (Jap. J. Clin. Hemat. 15: 191, 1974).
    On Octover 22, 1973, the patient was admitted to Nara Medical University Hospital, because of nausea, abdominal pain and fever for one day.
    Physical examination revealed a moderate muscle defense, press pain of McBurney's point and positive Rosenstein's sign. No ecchymosis on the trunk and extremities. An appendectomy was performed under a cover of infusion with 6gm human fibrinogen preparations. The factor XIII activity rose to 10U/ml (20% of normal value) one hour after the infusion. The operation was done uneventfully. The appendix was purulent and gangrenous. On 7th postoperative day, the factor XIII activity demonstrated to be 2.5U/ml, and 4gm of human fibrinogen preparation was infused again. Shortly after the infusion threads were removed partially. No bleeding was observed. A complete removal of the suture was done on the 13th postoperative day, without an abnormal bleeding. On the 16th postoperative day, 4gm of human fibrinogen was given as the plasma level of factor XIII decreased to 2.5U/ml (5% of normal value). The wound healed normally. The patient was discharged after six week-hospitalization.
  • 1975 年 21 巻 4-6 号 p. 103-167
    発行日: 1975年
    公開日: 2010/03/12
    ジャーナル フリー
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