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28 巻, 1 号
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神田 靖男, 川平 宏, 阿部 まを, 石野 たい子, 武尾 宏, 雨宮 洋一1982 年 28 巻 1 号 p. 1-6
発行日: 1982年
公開日: 2010/03/12
ジャーナル フリーAnti-erythrocyte antibodies were detected in 56 (0.99%) of 5619 patients with various diseases and most of them contained anti-Lewis, Rh and P1 antibodies.
The antibodies were detected in 14 (5.3%) of 264 pregnant women and most of them contained anti-RhD and E antibodies. Moreover, the antibodies were detected in 33 (0.22%) of 14, 900 healthy blood donors, and most of them contained anti-Lewis and P1 antibodies.
The other antibodies seemed to be natural antibodies of type IgM in all healthy blood donors expect three cases, of whom one had a history of blood transfusion and the other two had a history of pregnancy. Most of patients with unidentified antibodies were positive for direct Coombs test but in patients with negative direct Coombs test, the antigen-antibody reaction occurred at low temperature zone by using saline and 22% albumin methods.
These results suggested that such methods as detecting anti-RhD, E Lewis and P1 antibodies should be used in the identification of anti-erythrocyte antibodies.
Moreover, autoimmune hemolytic anemia (AIHA) characterised by positive direct Coombs test developed in a patient with severe epilepsy who had been administered a large amount of anti-epilepsy agents for long term. It was appeared that the cause of AIHA was due to phenitoin (Aleviatin) following clinical course. In case like this patient, all chemicals should be immediately discontinied and other drugs being different structures should be used property, also, hematological and immunological examination should be done.抄録全体を表示PDF形式でダウンロード (784K) -
吉岡 章, 阪井 利幸, 嶋 緑倫, 三上 定昭, 福井 弘, 河崎 則之, 増原 健二1982 年 28 巻 1 号 p. 7-16
発行日: 1982年
公開日: 2010/03/12
ジャーナル フリーA surgical case was described of 40-year-old hemophilia A with chronic blood cyst on the right thigh and with a potent factor VIII inhibitor (40 Bethesda units). Surgery was performed under extensive plasmapheresis and a large amount of infusion of factor VIII concentrate (42, 500 U on the first operation day). During 5 days following operation, factor VIII level was maintained at over 25%, which enabled us to control hemorrhage. However, two serious problems, i. e., hemolytic anemia and anamnestic rise in factor VIII inhibitor titre, appeared on the 6th day after operation. The former healed by administration of prednisolone. For the latter problem, prothrombin complex concentrate was given every 8hrs for 12 days until the sutures of operation wound were removed. There was no bleeding although inhibitor titre rose to 460 Bethesda units.抄録全体を表示PDF形式でダウンロード (4806K) -
服部 絢一1982 年 28 巻 1 号 p. 19-23
発行日: 1982年
公開日: 2010/03/12
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Robert Peter Gale1982 年 28 巻 1 号 p. 24-30
発行日: 1982年
公開日: 2010/03/12
ジャーナル フリーBone marrow transplantation is increasingly used to treat patients with bone marrow failure whether due to abnormalities of hematopoietic stem cells or to cancer. In this manuscript we will review the current status of bone marrow transplantation in two diseases, aplastic anemia and leukemia. Specific problem areas will be discussed in detail.抄録全体を表示PDF形式でダウンロード (898K) -
Scott Murphy1982 年 28 巻 1 号 p. 31-33
発行日: 1982年
公開日: 2010/03/12
ジャーナル フリーPDF形式でダウンロード (457K) -
1982 年 28 巻 1 号 p. 34-120
発行日: 1982年
公開日: 2010/03/12
ジャーナル フリーPDF形式でダウンロード (16377K)
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