Five hundred thrombocytaphereses by discontinuous centrifugation were retrospectively analyzed to elucidate platelet mobilization during thrombocytapheresis.
Platelet mobilization per apheresis was 1.937±1.521×10
11 (mean and SD) and was positive in 85% and almost zero in 10%. Five per cent showed negative mobilization due to redistribution from body circulation into the pool.
The time of apheresis was positively correlated to the size of mobilization (p≈0.002), which was considered to be the main cause of better platelet yield in the slower apheresis. Statistical analyses demonstrated increase in blood voulme or decrease in hematocrit to be an important factor to promote positive mobilization (p<0.001).
In five of thirty six donors received apheresis twice, the platelet mobilization was negative in one apheresis and then positive in the other, suggesting the presence of certain conditions which cause negative mobilization.
In comparison with the group of positive mobilization, the negative group was significantly higher in preapheresis platelet counts and smaller in increase in blood volume or in decrease in hematocrit during the apheresis (p<0.001).
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