巻号一覧
45 巻, 4 号
選択された号の論文の10件中1～10を表示しています
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松本 尚浩, 重松 昭生1999 年 45 巻 4 号 p. 425-429
発行日: 1999/08/01
公開日: 2010/03/12
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霜山 龍志, 関口 定美1999 年 45 巻 4 号 p. 430-435
発行日: 1999/08/01
公開日: 2010/03/12
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佐藤 典宏, 茂木 祐子, 上田 恵里奈, 金井 ひろみ, 小島 聡, 中瀬 俊枝, 池淵 研二, 関口 定美1999 年 45 巻 4 号 p. 436-441
発行日: 1999/08/01
公開日: 2010/03/12
ジャーナル フリーWe evaluated the efficacy of measurement of CD 34+ cells in peripheral blood (PB) before leukapheresis (LA). Forty-five patients with malignant diseases underwent 65 LAs for collection of peripheral blood progenitor cells (PBPC). Median values for white blood cells (WBC), mononuclear cells (MNC) and CD 34+ cells in PB before LA were 18, 900/μl, 3, 110/vl and 39.6/μl, respectively. Median values for CD 34+ cells, colony forming unit-granulocyte/macrophage (CFU-GM) and total colony forming cells (CFC) in LA products were 3.19×106/kg, 5.7×105/kg and 12.90×105/kg, respectively. The strong correlation between CD 34+ cells and CFU-GM or CFC (r=0.88 and 0.87) indicates that the number of CD 34+ cells represents clonogenic activity. Regression analysis revealed a very strong correlation between CD 34+ cells in LA products (Y) and those in PB before LA (X) (r=0.97, Y=5.43×105X-37.2×105), while only a weak correlation was seen between CD 34+ cells in LA products and the number of WBC and MNC in PB before LA (r=0.60 and 0.56). These results indicated that the number of CD 34+ cells in PB before LA can accurately predict that in LA products. We therefore conclude that the measurement of CD 34+ cells in PB before LA is useful in the collection of PBPC with LA.抄録全体を表示PDF形式でダウンロード (1986K) -
高橋 陽子, 新井 盛夫, 腰原 公人, 香川 和彦, 山元 泰之, 田中 朝志, 福江 英尚, 福武 勝幸1999 年 45 巻 4 号 p. 442-448
発行日: 1999/08/01
公開日: 2010/03/12
ジャーナル フリーAccidental exposure to blood-borne pathogens by contaminated needlestick puncture is a continuing problem for health care workers. We established an infection control center where infection control and follow-up programs are carried out for employees who suffer from accidental needlestick puncture. We analyzed 1062 needlestick accidents that occurred during an 8-year period from May 1990 to April 1998. Of these, 461 (43.4%) occurred in nurses and 392 (36.9%) in doctors; further, 668 (62.9%) occurred during normal needle use while 170 (16%) occurred during recapping. Needles contaminated with blood containing hepatitis C virus (HCV) accounted for 259 (24.4%) accidents. From these 259 incidents, two employees were infected with HCV and suffered acute hepatitis. Accidental exposure to contaminated blood was more likely between May and October and less likely between November and February.抄録全体を表示PDF形式でダウンロード (2704K) -
佐々木 大, 小砂子 智, 小宮山 祥光, 鈴木 光, 中野 月子, 清水 哲夫, 神谷 忠, 平沼 隆明, 高良 真一, 西岡 克郎, 伊 ...1999 年 45 巻 4 号 p. 449-455
発行日: 1999/08/01
公開日: 2010/03/12
ジャーナル フリーIn Japan, most platelet concentrates (PC) are presently collected by plateletpheresis machines and suspended in autologous plasma. Transfusion of PC occasionally induces non-hemolytic side reactions in thrombocytopenic patients by unknown factors in plasma. To prevent these side effects, removal of autologous plasma from PC has been used with a synthetic medium used for resuspension of platelets. In this study, we compared two methods for washing platelet concentrates (WPC), one by centrifugation to a platelet pellet (P-WPC) and the other using a plateletpheresis machine (CS3000 plus) to non-pelleted platelets (CS-WPC). Both these methods allowed removal of nearly all plasma in PC. Platelet recovery with CS-WPC (98.56%) was greater than that with P-WPC (91.07%). LDH release into the supernatant was lower with CS-WPC than with P-WPC. Platelet discoid ratio and ADP/collagen aggregation in CS-WPC were also greater than those with P-WPC. However, other indicators such as pH, pCO2, PO2, MPV, %HSR, P-selectin release and lactate concentration in the supernatant were not significantly different between the two methods. These results suggest that this new washing method with the CS3000 plus plateletpheresis machine is useful for the preparation of WPC with an acceptable quality of platelets.抄録全体を表示PDF形式でダウンロード (789K) -
岸本 昌浩, 大戸 斉, 色摩 弥生, 相楽 浩哉, 君島 伊造, 阿部 力哉1999 年 45 巻 4 号 p. 456-461
発行日: 1999/08/01
公開日: 2010/03/12
ジャーナル フリーAs the volume of blood processed in harvesting peripheral blood stem cells (PBSCH) for autologous stem cell transplantation increases, clinical symptoms associated with hypocalcemia can occur. In this study, we evaluated several calcium supplementation methods for the prevention of hypocalcemia during PBSCH apheresis.
Ionized calcium (ICa) level in peripheral blood was measured in 35 procedures in 19 patients. ICa in patients with hypocalcemic symptoms was lower than that in those without symptoms, but the difference was significant only at 120 minutes of apheresis. Continuous injection of calcium during the procedure kept ICa almost within the normal range in three patients. In six patients who took an isotonic drink per os at the time symptoms appeared, ICa value increased within 3 minutes after intake.
As hypocalcemia-associated symptoms mostly appeared at 120 minutes after the start of the procedure, prophylactic treatment is not difficult. Further, continuous injection of pharmaceutical calcium into a venous port with measurement of ICa is an excellent method for infants and patients unable to take isotonic drinks orally. Oral administration of an isotonic drink is the most effective way to control ICa level, even though these drinks have a low Ca content.抄録全体を表示PDF形式でダウンロード (3745K) -
山口 富子, 安田 広康, 佐藤 久美子, 岩渕 伸枝, 赤間 敏子, 大戸 斉1999 年 45 巻 4 号 p. 462-465
発行日: 1999/08/01
公開日: 2010/03/12
ジャーナル フリーWe prospectively evaluated the polyethylene glycol-indirect antiglobulin test (PEG-IAT) for its usefulness as a routine technique for screening unexpected antibodies against red cells. Sera of 999 consecutive parients obtained between December 1996 and March 1997 were tested by PEG-IAT in comparison with the saline, bromelin and alubumin-indirect antiglobulin (Alb-IAT) methods.
Of 999 sera, 15 contained red cell antibodies. 9 of these were reactive with both the PEG-IAT and Alb-IAT methods. 4 of the remaining 6 sera were detected only by PEG-IAT, namely 3 anti-E and 1 warm-type autoantibody. 2 cold-type anti-Leb antibodies were detected by saline and Alb-IAT, but not by PGEG-IAT.
PEG-IAT could clinically detect significant IgG-type antibodies such as anti-Rh or anti-Kidd, indicating its suitability as a routine test.抄録全体を表示PDF形式でダウンロード (432K) -
廣瀬 優子, 竹下 昌一, 正木 康史, 大島 恵子1999 年 45 巻 4 号 p. 466-470
発行日: 1999/08/01
公開日: 2010/03/12
ジャーナル フリーA 70-year-old female was admitted with anemia and thrombocytopenia. Her blood type was B Rho (+). Her RBC was 250×104/μl, Hb7.8g/dl, Ht 23.2%, Retic. 55‰, WBC 2900/μl, T. bil 0.3mg/dl, LDH 917U/L, and Haptoglobin <10mg/dl. Cold agglutinin titer was×1024, direct Coombs test (-), indirect Coombs test (4+). Antibody screening test in saline revealed serum agglutinated adult O cells (4+) (×512), adult i cells (+) (×64), cord cells (-) and B cells (-), leading to an antibody diagnosis of anti-HI antibody. She subsequently developed thrombocytopenia (16×103/μl) and PAIgG was 54.8ng/107 platelets, giving a diagnosis of idiopathic thrombocytopenic purpura together with cold agglutin disease. The presence of cold agglutinin disease due to anti-HI antibody and development of ITP indicated this to be a case of Evans syndrome. Hemolytic anemia due to anti HI antibody is very rare, as is the association of ITP with cold agglutination disease.抄録全体を表示PDF形式でダウンロード (530K) -
1999 年 45 巻 4 号 p. 596
発行日: 1999/08/01
公開日: 2010/03/12
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日本医学会1999 年 45 巻 4 号 p. 597-598
発行日: 1999/08/01
公開日: 2010/03/12
ジャーナル フリーPDF形式でダウンロード (284K)
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