We report a case of delayed hemolytic transfusion reaction (DHTR) in which the presence of anti-Jk
b antibodies (abs) in a pretransfusion specimen was confirmed by retrospective investigation.
The patient, a 55-year-old woman, received 3, 000ml of concentrated red blood cells (CRC) during repeat mitral valve replacement surgery. Anti-Jk
b+E abs were detected by an indirect antiglobulin test using polyethylene glycol (PEG-IAT) 7 days after transfusion. The patient received two transfusions of insert 400ml of CRC with Jk
b-, E-antigen negative blood which was transfused for treatment of anemia. However, laboratory findings consistent with hemolysis were observed 17 days after the operation, and anti-Jk
b+E abs were identified from an elute of the patient's red cells with a direct antiglobulin positive test result. No special treatment was administered, however, and after 6 days, these findings disappeared entirely. The patient received compatible blood during a repeat operation, and there was no evidence of clinical hemolysis.
Anti-Jk
b abs were detected in this patient's preoperation sample by retrospective investigation using the Capture R Ready Screen (CRRS). Our case highlights the limitations of PEG-IAT. Therefore, it is considered that pretransfusion testing should be performed in combination with plural methods, especially for patients with a history of transfusion and pregnancy.
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