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Volume 48, Issue 1
Displaying 1-5 of 5 articles from this issue
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Makoto Yoshiba, Kazuaki Inoue2002 Volume 48 Issue 1 Pages 9-26
Published: March 01, 2002
Released on J-STAGE: March 12, 2010
JOURNAL FREE ACCESSDownload PDF (2769K) -
Yoshio Takeda, Ikuma Abe, Motonaka Aoki, Koji Sotoyama, Nariaki Kimura ...2002 Volume 48 Issue 1 Pages 27-31
Published: March 01, 2002
Released on J-STAGE: March 12, 2010
JOURNAL FREE ACCESSSince September 1997 the Japanese Red Cross has conducted a nationwide complete screening of human parvovirus B19 (B19) for all donated blood units by the receptor-mediated hemagglutination (RHA) method. RHA-positive units were excluded from source plasma for fractionation. The amounts of B19 DNA in pooled plasma and in factor VIII concentrates (Cross Eight M, plasma derived and monoclonal purified) were measured using a PCR method. All 112 batches of pooled plasma tested in 1996, before implementation of RHA screening, were B19 DNA-positive, with 83% of these contaminated with more than 3.8×105IU/ml of B19 DNA. In contrast, after implementing RHA screening, no detectable levels of B19 DNA were observed in 5% (1998), 16% (1999), 21% (2000) and 21% (2001) of batches, and batches contaminated with more than 3.8×105IU/ml of B19 DNA decreased to 18% (2001). B19 DNA content in the final products of factor VIII concentrate were reduced significantly when RHA-screened source plasma were used. Since September 1998, B19 DNA has not been detected in any of 78 lots of final products. Furthermore, no B19 DNA could be detected in any of 63 lots even in 1:10 concentrated solution. RHA screening for B19 has markedly reduced the viral load in source plasma for fractionation in Japan.View full abstractDownload PDF (1622K) -
Mayumi Asada, Chiemi Sugano, Kayo Kawamoto, Shiho Ito, Yoshiko Mine, M ...2002 Volume 48 Issue 1 Pages 32-36
Published: March 01, 2002
Released on J-STAGE: March 12, 2010
JOURNAL FREE ACCESSMost non-hemolytic transfusion reactions (NHTR) following transfusion of authentic platelet concentrates (PC) into patients were allergic symptoms such as rash, itching and urticaria. To prevent these adverse effects, plasma of PC was removed by centrifugation, and then peletted platelets were resuspended in either saline solution including ACD-A solution or in modified Seto solution (MSS), which includes the acetate Ringer solution with glucose, sodium hydrogen carbonate, ACD-A, and water for injection. PH of MSS was 6.62. We compared aggregation responses to ADP plus collagen of washed platelets, which had been resuspended with continuous agitation immediately or 30min after the addition of the MSS additive solution. The aggregation responses of 72-hr-old platelets were maintained when plasma-depleted platelets were resuspended with MSS after the 30-min rest period. The average CCI of transfused platelets in MSS was 7576 at one day after.
Mean incidence rates of adverse reactions by transfusion of washed PC were dramatically decreased from 50.4% to 2.2% in 71 patients compared to rates with the authentic PC. The present data indicate that platelets washed with MSS are a useful alternative in decreasing allergic NHTR in patients.View full abstractDownload PDF (581K) -
Shin Chiyoda, Tamaka Aguin, Toshinobu Ezaki, Yoshirou Mitutomi2002 Volume 48 Issue 1 Pages 37-38
Published: March 01, 2002
Released on J-STAGE: March 12, 2010
JOURNAL FREE ACCESSDownload PDF (189K) -
2002 Volume 48 Issue 1 Pages 54-55
Published: March 01, 2002
Released on J-STAGE: March 12, 2010
JOURNAL FREE ACCESSDownload PDF (193K)
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