We performed clinical experience investigation on safety and efficacy of MIMIENA^®, a pimaricin otic suspension for canine otitis externa. The investigation on safety was to survey mainly a trend of adverse drug reactions (ADRs). The efficacy of MIMIENA^® evaluated in this study including the anti-fungal activity of that against M. pachydermatis as a causative agent of otitis externa was compared with the result in clinical trial before approval. Among 644 dog cases collected for the safety evaluation, 555 cases and 82 cases were used for the efficacy evaluation and for comparison of efficacy between the result in this investigation and that in the clinical trial before approval, respectively. ADRs were observed 2 of 644 cases (0.31%) and were redness or pruritis at the local application sites. The frequency of ADRs in this investigation was not significantly different from that in the clinical trial before approval in which no ADRs were observed in 145 cases. The efficacy rate in 555 cases in this investigation was 74.1% and that in 82 cases was 73.2%, which was comparable with the efficacy rate in 65 cases in the clinical trial (73.9%). These results indicated that the efficacy of the medicine did not significantly change after marketing. We suspected the reason of the unchanged efficacy that the anti-fungal activity against causative agents of otitis externa might have been well maintained because MIC₉₀ against M. pachydermatis was 6.25 μg/ml and 4.0 μg/ml in approval result and in this study, respectively.

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We compared results of intradermal skin test with those of three commercially available IgE tests in dogs with atopic dermatitis. The results of intradermal skin tests and allergen-specific IgE tests were obtained in a total of 45 dogs with atopic dermatitis, of which 15 cases were tested in one company. Six common allergens (house dust mites, aspergillus, Bermuda grass, flea, ragweed short, plantein english) were examined for evaluation in allergen-specific IgE and intradermal skin tests. There were significant relationships between the results of skin and IgE tests (H company p<0.0001, G company p=0.0254, and S company p=0.0151).

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Multiple food hypersensitivity was observed in a parent (five-year-old male) and child (two-year-old male) of West Highland white terrier. The clinical signs were characteristic pruritus with facial and digital erythema and eruption, dermatitis of dorsal skin and chelilites. An allergic reaction developed against all hypoallergenic diets and homemade diets following one-year clinical improvement for with the protein hydrolysates diets.

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The diseases observed in 543 canine cases presented at an animal hospital in Tokyo from April 2002 to September 2004 were investigated. Skin diseases were seen in 41.1% of the cases (223 cases) including 109 cases of allergic dermatitis (20.1%). Among 109 cases with allergic skin disease, 59 cases (54.1%) were of atopic dermatitis and/or food allergy. These results were consistent with those reported in Europe and USA including breed predisposition.

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