The Japanese Journal of Veterinary Dermatology
Online ISSN : 1881-2236
Print ISSN : 1347-6416
ISSN-L : 1347-6416
Volume 21, Issue 2
Displaying 1-7 of 7 articles from this issue
Original
  • Maturawan Tunhikorn, Danny W. Scott, Hollis N. Erb
    2015 Volume 21 Issue 2 Pages 63-69
    Published: 2015
    Released on J-STAGE: July 29, 2015
    JOURNAL FREE ACCESS
    It has often been stated that large numbers of mast cells in skin-biopsy specimens from cats are consistent with allergic dermatitis. We performed a retrospective study of hematoxylin and eosin (H&E)-stained skin-biopsy specimens from cats with allergic (n=143) and nonallergic (n=228) inflammatory skin diseases. All specimens had been submitted to the Section of Anatomic Pathology of the Cornell University College of Veterinary Medicine between 1978 and 2010. We found that dermal mast cell numbers are not significantly different between allergic and nonallergic cats. We also found that mast cell numbers are higher in the superficial than the deep dermis in cats with allergic and nonallergic skin diseases. In normal cat skin (n=31), mast cell numbers in the superficial dermis were higher in toluidine blue-stained specimens than in H&E-stained specimens.
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Case Report
  • Takeo Nishiyama, Keita Iyori, Toshiroh Iwasaki, Koji Nishifuji
    2015 Volume 21 Issue 2 Pages 71-75
    Published: 2015
    Released on J-STAGE: July 29, 2015
    JOURNAL FREE ACCESS
    It has been reported that apoptotic keratinocytes were not observed in dogs with toxic epidermal necrolysis (TEN). Here, we describe a dog with TEN in which apoptotic cells were found in the epidermis. A 13-year-old female mongrel dog was presented with acute and extensive erythema, vesicles and ulcerations, especially on the ventral skin and visible mucous membranes. The dog also exhibited anorexia and lethargy. The dog was administrated oral amoxicillin 5 days before development of the skin lesions. Histopathological examination of the skin lesions revealed a full-thickness epidermal coagulative necrosis with lymphocytic exocytosis compatible with TEN. Immunohistochemical analyses indicated that infiltrative lymphocytes were positive for CD3. In addition, TdT-mediated dUTP-end labeling (TUNEL) positive cells indicated there were apoptotic cells in the epidermis including keratinocytes. Based on these findings, T cell-mediated apoptosis of the epidermal keratinocytes was considered as a possible pathomechanism of epidermal necrolysis in the present case.
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Brief Note
  • Mie Nishiyama, Keita Iyori, Maiko Sekiguchi, Toshiroh Iwasaki, Koji Ni ...
    2015 Volume 21 Issue 2 Pages 77-80
    Published: 2015
    Released on J-STAGE: July 29, 2015
    JOURNAL FREE ACCESS
    Here, we report two canine and one feline cases whose history and/or histopathological findings were compatible with thermal burn. Case 1 was a dog in which solitary ulcerated and necrotizing skin was recognized on the dorsal median line. Case 2 was a dog in which extensive ulcerated and necrotizing skin was recognized on the left scapular region. Case 3 was a cat in which alopecia, erythema, excoriation and scales were recognized on the lower and lateral abdominal skin. Histpathological findings were compatible to third-degree burn in cases 1 and 2 as well as deep second-degree burn in case 3. All of these cases were diagnosed as thermal burn as they had histories of contact with sources of heat before the disease development.
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