The sensitivity of mice to Histamine following injection of hemophylus pertussis phase I cells markedly increases as has already been reported by Parventjev and Goodline.
By heating 100°C 30 minutes the histamine-sensitizing property of the pertussis vaccine was remarkably reduced, although there remained a little.
It was found that H. parapertussis, H. bronchosepticus, and phase variants of H. pertussis do not show the histamine sensitizing effect.
Anaphylactic sensitivity of mice to foreigne protein (as goat serum) was evidently increased by the pertussis vaccine injection as well as the histamine sensitivity.
It seems that the diphtheria toxoid can diminish the histamine sensitivity of pertussis vaccinated mice.
It was found that the differnce of sex and body weight had not influence upon the sensitivity in case of the same strain of mouse.
The histamine sensitivity was remarkably increased when H. pertussis was infected to the mice through the nasal route.
The zyramine sensitivity on mice was not changed by the pertussis vaccination.

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The author has formerly discussed in this journal on some fundamental problems on the clinical use of antibiotics. This time, he states on the practical principles of chemotherapies, obtained from his clinical data of several major internal diseases, i. e. sepsis, pneumonia, lung suppuration, and cholangitis.
Cases of these diseases were examined for the effects of therapy, and statistically observed to enumerate the most effective drugs for each disease. The in vitro sensitivity tests on the causual bacilli were found to be of some significance in the sepsis cases. For patients with lung suppurations, intratracheal injections of penicillin were more effective than ordinary administration, especially when streptomycin was combined with penicillin. In the cholangitis cases, inc coincidence of clinical and experimental conclutions on the marked efficacy of chloramphenicol was confirmed.
These findings of the author may be useful for the proper selection of chemotherapeutics in the practice of internal medicine.

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The influence of the injection of Cortisone and ACTH on the function of rabbit's reticuloendothelial system was studied by Adler-Reimann's Congo red method.
The injection of Cortisone on rabbit causes the temporal decrease of the new Congo red index, but in 30 or 60 minutes the index shows rapid increase and maintains its highest value for 6 to 48 hours.
In allmost all cases the injection of ACTH on rabbit causes the temporal decrease of the new Congo red index and it soon increases and shows its highest value in 3 to 6 hours, which continues for 48 hours.
The stimulation on the reticuloendothelial system is stronger and continues longer by ACTH than by Cortisone.

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Phagocytic action showed in vitro to india ink solution by histiocytes that exist in the subcutaneous tissue was temporarily stimulated by Multin and goat's serum. The influence of the solution of soluble starch on the phagocytic action of this cell was not so evident.
It seems that the direct action of such materials as Multin or serum protein on the phagocytic action of histiocytes that exist in the subcutaneous tissues which exscinted from the living body is not so specific and remarkable. After the function of these agents, the phagocytic action to india ink granule is generaly stimulated in 5 to 10 minutes and then weakened. And the more violent the stimution is, the more the phagocytic action lowers afterwards.
Decrease of the phagocytic action seems to be due more to the decrease of living power of the hitiocytes in the exscited subcutaneous tissue than to the direct action of the agents or any foreigne protein.

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[in Japanese]

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[in Japanese]

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[in Japanese]

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4% sodium iodate was daily injected into the ear vein of the rabbits in the daily dose of 1 cc/kg for 7 days.
Histological and histochemical examinations were done about the retina.
The main results were as follows:
Ophthalmoscopic findings:
In the retina of white rabbits, chorioid vessels under the meduallary line were observed twist, tear and anastomosis from the first day after the application. The arteria was contracted, vein was dilated and retina vessels were contracted day by day. Brown pigments were appeared in the anastomosis portions from 5-6 days after the application.
About black rabbits, matation of vessels were considerable than white one. Histological and histochemical findings:
About the pigment epithelium of white and black rabbsts, there were a few degenerations of nucleus, deposit of granular pigments considerrably in black and slighly in white one. About bacillary layer there were degeneration and collaps in black, but there were pycnosis and diminution of cell on white one. In the inner nuclear layer and ganglion cells, middle on black and slight degenerations on white were observed.
PAS positive substances in the inner segment were increased, granula of iron on the outer segment were extinguished, bacillary disposition of copper in the outer segment were diminution and confusion after the administration. RNA in the inner segment were diminution, but in the outer segment were increased. Hamazaki's KEG substances in the pigment epitheliums and outer segment were inereased or extinguished after the application. Phosphatase in the retina were increase after the application.

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The author tried to investigate the intoxicating influences of naphthol AS-BO and the protecting influences of DL-methionine, glucuronic 'acid and NK 143 (Photosensiting dye) upon the kidney of rabbits. The results obtained were as follows:
There were the increase of body weight after the application of naphthol AS-BO. The. combined application with glucuronic acid developed a eminent influences.
After the application of naphthol AS-BO, there were observed many nephrotic changes in kidney such as the atrophia and congestion of the glomerulus, the cloudy swelling, the vacuolar degeneration, the pyknosis, the epithel desquamation, the cylinder formation in the tubulus renalis and Henle's loop. Such changes were observed in the case of the combined application with DL-methionine, glucuronic acid and NK 143 too.
The deposit of iron by Perls's method were observed in the proximal convolution after the application in the all cases.
RNA in the tubulus ranalis and Henle's loop were decreased after the application.
Phosphatase in the tubulus renalis and Henle's loop were observed a few increase.
At the histochmical researches the influences of DL-methionine, glucuronic acid and NK 143 were not observed.
Then, the pathological action of naphthol AS-BO for the kidney of rabbits was a regressive degeneration, such as nephrose, was not a progressive degeneration.

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