関西医科大学雑誌
Online ISSN : 2185-3851
Print ISSN : 0022-8400
ISSN-L : 0022-8400
11 巻, 3 号
選択された号の論文の17件中1~17を表示しています
  • Tooru Matsumoto
    1959 年 11 巻 3 号 p. 392-418
    発行日: 1959/08/20
    公開日: 2013/02/19
    ジャーナル フリー
    Die Entwicklung, insbesondere die Genese Sinnesorgans der Seitenlinie ist bei 5Arten von Anuren (Rana temporaria ornativentris, R. japonica, R. nigromaculata, Bufo vulgaris japonicus und Rhacophorus schlegelii arborea) und einer von Urodelen (Hynobius nebulosus) untersucht worden. Das Hauptergebnis lasst sich folgendermassen zusammenfassen.
    1. Das Seitenorgan entsteht an Anuren kurz v or dem Auftreten des Augenbechers und der Anlage der Linse, wahrend an Urodelen nach der Differenzierung des Augenbechers und zwar kurz vor dem Erscheinen der Anlage der Linse.
    2. Das seitenorgan entsteht als primare Sinne s knospe aus der Hautgrundschicht (Sinnes-schicht). Diese nach mir genannte primare Sinnesknospe mag der Verdickung der Hautgrundschicht, “Anlage der Seitenlinie” nach HARRISON, R. G. (1904), oder von STONE, L. S. (1921-'36) und anderen Autoren beschriebenen “Plakode als Anlage des Sinnesorgans” entsprechen. Meine Ansicht uber die Entwicklungsvorgange der primaren Sinnesknospe ist jedoch vollstandig verschieden von den Meinungen der anderen Forschern.
  • 池田 リヱ子
    1959 年 11 巻 3 号 p. 419-425
    発行日: 1959/08/20
    公開日: 2013/02/19
    ジャーナル フリー
    Cardiazol (C), megimide (MG), methylpropamine (MP) and l-1,2-diphenyl-1-dimethylaminoethan (Spa) were used to study their effects on pentobarbital anesthesia in mice. C and MG were in moderate to large doses, antagonist against pentobarbital for the toxicity and also in the duration of anesthesia. A small dose of pentobarbital protected mice against C or MG convulsion. Small doses of C and MG, however, were found to be synergism to pentobarbital since light anesthesia was prolonged in contrast to the above results. Both MP and Spa were antagonistic against pentobarbital anesthesia while at large doses of MP or Spa synergism occurred and the toxicity was more serious than that of each drug. From these findings it was supposed that some nerve structures of cerebral limbic system might be affected by these central stimulants, resulting in certain condition the decrease in activity of cerebral cortex or brainstem reticular formation.
  • 池田 リヱ子
    1959 年 11 巻 3 号 p. 426-430
    発行日: 1959/08/20
    公開日: 2013/02/19
    ジャーナル フリー
    Antagonism of tridione against cardiazol or megimide was investigated in mice. In pentobarbital-treated mice the two phasic actions of cardiazol or megimide were reported in previous paper and in this paper the influences of tridione on these cardiazol or megimide action were investigated using the same method.
    1) Cardiozol-as well as megimide-induced seizures were antagonized by small dose (1-5mg/10g) below those causing obvious neurological depression in mice.
    2) Pentobarbital anesthesia was shortened by 1mg of tridione in its duration. This arousal effect of tridione was manifested under light anesthesia after pentobarbital.
    3) Arousal effect of tridione in pentobarbital anesthesia was diminished or antagonized by convulsant dosage of cardiazol or megimide.
    4) It was discussed that tridione may act cerebral limbic system to cause its depression.
  • 大城 和子
    1959 年 11 巻 3 号 p. 431-445
    発行日: 1959/08/20
    公開日: 2013/02/19
    ジャーナル フリー
    1) It is demonstrated on a new “glycerine spot method” (1952, Kotsuka) that efferent vasodilator fibers and efferent vasoconstrictor fibers exist in the oculomotor nerve in bullfrog's and frog's external eye muscles.2) It is interpreted that the blood vessels of bullfrog's and frog's external eye muscles are subjected to “double oculomotor innervation”.3) It is revealed on a temporarily designated “carmin nicotine microinjection method” that oculomotor vasodilator fibers and oculomotor vasoconstictor fibers have their own origin in the mesencephalon.
  • 幸塚 嘉一, 内藤 博江, 浅井 茂次, 堀川 惺子, 三戸 裕
    1959 年 11 巻 3 号 p. 446-449
    発行日: 1959/08/20
    公開日: 2013/02/19
    ジャーナル フリー
    1) It is demonstrated that there exist efferent sympathetic pupilloconstricting fibers in the cervical sympathetic trunk of cats and rabbits besides so far accepted efferent sympathetic pupillodilator fibers.
    2) The efferent pupilloconstricting fibers in the cervical sympathetic trunk have no cell stations in the superior cervical ganglia.
    3) The results of 1) and 2) are correspondent with already verified results referring to the pupilloconstricting action of “efferent posterior sympathetic nerves” of cold blooded animals. In analogous to cold blooded animals, the present experimental results lead to conclude that “the efferent sympathetic nerves” of warm blooded animals such as cats and rabbits are possessed with pupilloconstricting actions.
    4) It is assumed that the dilator muscle of the iris of cats and rabbits are subject to “efferent double sympathetic innervation”.
  • 浅井 茂次
    1959 年 11 巻 3 号 p. 450-466
    発行日: 1959/08/20
    公開日: 2013/02/19
    ジャーナル フリー
    1) It is demonstrated on a new “glycerine spot method” (1952, Kotsuka) that there exist vagal vasoconstrictor fibers in the mesenterium of frogs and bullfrogs besides alrady verified vagal vasodilator fibers.
    2) The above findings demonstrate that the blood vessels of frog's and bullfrog's mesenterium are subject to a double vagal innervation.
    3) It is evidenced that there exist vagal vasoconstrictor fibers, vagal vasodilator fibers, anterior sympathetic vasoconstrictor fibers and posterior sympathetic vasodilator fibers in the vagosympathicus of frogs and bullfrogs. The blood vessels of mesenterium are subject to vasomotor innervation of these fibers.
  • Nobuko Matsui
    1959 年 11 巻 3 号 p. 467-474
    発行日: 1959/08/20
    公開日: 2013/02/19
    ジャーナル フリー
    Four mutants derived from a strain of Pseudomonas aeruginosa is studied on precipitation and complent fixation reactions with the following results:
    1) Precipitin reaction with the isolated endotoxin reveals no common features between No.117 and No.134 strains. No.134 strain and No.145 strain are very similar, but No.58 strain shows a similarity only to No.134.
    Homma's A and C strains are similar to No.134 strain, but bear no kinship to Homma's B and D strains.
    2) The findings of complement fixation reaction reveals the endotoxig roft, N4a.117 is positive with No.134 (OH) and No.145 (OH) antisera and that No.117 endotoxin and that of No.58 strain show a similar response. The endotoxins of No.134, No.145, A, and -C strains show a similar reaction to one another. No.58 strain is analogous to B strain.
    3) The specificity of O-antigen observed in agglutinin reaction (Report I) is also observed. in endotoxin. But this specificity is the most intensive in the precipitin reactin of endotoxin.
    A similar specific reaction appears together with a comparatively wide ranged additional reaction. The range of this additional reaction generally corresponds to the result of precipitin and O-agglutinin reactions. But it is not always correspondent.
    4) The results of agglutinin, precipitin, and complement, fixation reactions reveal that those which are positive in these reactions show high titers. Those which are positive in one or two of these reactions generally show low titers.
  • Nobuko Matsui
    1959 年 11 巻 3 号 p. 475-481
    発行日: 1959/08/20
    公開日: 2013/02/19
    ジャーナル フリー
    1) Two mutant strains obtained from a strain of Pseudomonas aeruginosa isolated from the blood of a septic patient; another strain of Ps. aeruginosa is isolated from an ulcerated lesion of the same patient.
    Of these strains, endotoxins are obtained on a trichloracetic acid method.
    2) Purified endotoxins are electrophoretically homogenous.
    The solutions of 0.1 per cent of these endotoxins are Molisch reaction, Bial's orcin-HC1 reaction, Ninhydrin test and Sakaguchis' test positive.
    3) Polysaccharide fractions of No.134 and No.002 endotoxin consist of glucose, xylose, rhamnose and unknown monosaccharide. Polysaccharide fraction of No.117 endotoxin consists of glucose, galactose, xylose, rhamnose and glucosamine.
    4) The endotoxin of No.117 strain shows no typical pyrogenic effect on rabbits and its toxicity to mouse is much lower than that of ordinary Ps. aeruginosa strain.
    I wish to express my great indebtedness to Prof. S. Osawa for his assistance in the reading of proof and offering many useful suggetions. The kindness of Associate Prof. E. Inoue is also gratefully acknowledged. Thanks, deeply felt, are due to Associate Prof. S. Higashi, Kyoto University who has contributed to the experiment.
  • 大沢 忍, 井上 恵美子, 松井 信子, 奈良野 芳江, 簡 雪桜
    1959 年 11 巻 3 号 p. 482-487
    発行日: 1959年
    公開日: 2013/02/19
    ジャーナル フリー
    A study is made of the DOPA oxidase of 4 strains of P. aeruginosa with an electrophotometer. Regarding a glycerol broth of detected 3 or 5 days culture, DOPA oxidase is highest in the cultured fluid of the strains producing pyocyanin; rather in a slight degree in a supernate whose cells has been centrifuged.
    The melanin producing strain shows little oxidation in the cultured fluid or in the supernate. Cultured of the white strain (no pigment producing strain) seems to inhibit oxidation as a whole but it demonstrates oxidation in the supernate. If strains grown on an agar medium are washed and added with DOPA solution, either the pyocyanin strains or the melanin strain function little; the cell suspension of the white strain reveals a considerable inhibition of oxidation at the initial stage.
  • 簡 雪桜
    1959 年 11 巻 3 号 p. 488-512
    発行日: 1959/08/20
    公開日: 2013/02/19
    ジャーナル フリー
  • 人見 正博
    1959 年 11 巻 3 号 p. 513-528
    発行日: 1959/08/20
    公開日: 2013/02/19
    ジャーナル フリー
    The authors have reported that the platelet and leucocyte number in the peripheral blood of normal rabbits increased obviously by the administration of adenine, and it has been discussed that adenine acted on bone marrow chiefly and drove out neutrophils to the blood. In this paper it was observed the influence of adenine, theophylline and xanthine on the decrease of the leucocyte number after acute bleeding with the following results.
    1) In normal rabbits the leucocyte number decreased by the acute bleeding ( 10 cc. per Kg. ) from the heart, and it minimized after 1 to 2 hours and returned gradually to the initial level after 3 to 5 hours.
    2) By the administration of adenine or theophylline, the decrease of the leucocyte number of rabbit after bleeding did not occurred, or did transiently followed by the obvious increase.
    3) Xanthine did not influence on the decrease of the leucocyte number after the acute bleeding. Thease results showed that adenine or theophylline increased the leucocyte number in the peripheral blood of the rabbits after the acute bleeding as markdly as in normal rabbits.
  • 大沢 忍, 人見 正博
    1959 年 11 巻 3 号 p. 529-535
    発行日: 1959年
    公開日: 2013/02/19
    ジャーナル フリー
    A report is made of a newly contrived blood coagulometer with a descriptive apparatus as to its construction, manipulation, and practical experiences. The extent of practicability and exactness of the contrivance as well as the resultant findings will be reported some other time.
    The contrivance consists of a time marker, attached to an elastic descriptive apparatus and connected with a thin metal soaked in a small basin, in which collected venous blood. The metal ring is made to move up and down for certain seconds, so that the change in resistance due to a progressive increase of viscosity as coagulation develops are recorded in a carbon paper of kimographion.
    This contrivance enables one to record the time for development and completion of coagulation as well as the changes in resistance during coagulation by the gram. The begining of coagulation is indicated by a 5 mg marking on the metal ring inversed in a blood basin. The completion of coagulation is indicated by a 130 mg marking.
    When the metal ring works every 30", the range between high and low value on the same blood specimen measurement is 130", the range on the same individual blood is 190". The results of mesurement by the metal ring for different movement time will be reported later.
  • 田中 美知子
    1959 年 11 巻 3 号 p. 536-569
    発行日: 1959/08/20
    公開日: 2013/02/19
    ジャーナル フリー
    A review was made of changes in cohort tuberculosis death rates in Japan since 1900 in reference to periodical epidemiological considerations in order to study the recent tuberculosis deach rates on age classification.
    1. Yearly changes in tuberculosis death rates on age classification resulted in the following four classifications.
    The first period: The latter Meiji era (the Meiji era covered 1868-1912) when tuberculosis death rates increased for all age groupsthe initial time of epidemic.
    The secound period: The period between the beginning of Taisho era (the Taisho era covered 1912-1916) and the Shanghai incident (1933) when tuberculosis death rates yearly increased for the young generation showing a gradual decrese for the other age groupsthe time of prolonged high tuberculosis death rate.
    The third period: The period between 1933 and the end of World War 11 (1945) when tuberculosis death rates for all age groups especially for the younger generation rapidly increasedthe secand time of epidemic. The fourth period: The period since 1945 to date when tuberculosis death rates for all ages have shown a yearly decreasethe time of decreasing tuberculosis death rates.
    2. The changes in cohort death rates were represented as follows:
    1) Those, especially females, who had been born in 1866-1880 and who had passed their tuberculous susceptible days in the initial time of epidemic showed yearly increasing tuberculosis death rates during their adolescence.2) Those who had been born in 1881-1905 and who had passed the initial time of epidemic in their adolescence and the latter half of their active days in the second time of epidemic showed their tuberculosis death rates slightly high in their infancy, considerably high in their adolescence being followed by another elevation in their adult days.
    3) Those who had been born in 1906-1925 who had passed their adolescence during World War 11 showed very high tuberculosis death rates in their adolescence and rapidly decreased tuberculosis death rates in the time of decreasing tuberculosis death rates.
    4) Those who had been born in 1926-1935 and who had passed their young and adolescent days in the post-war period showed slightly high tuberculosis death rates in their infancy and adolescence.
    5) Those who had been born after 1936 showed slightly high tuberculosis death rates in their infancy. The rates, however, showed a gradual decrease with advanced age.
    3. Tuberculosis death rates on male age classification in 1955 showed a gradually increasing curve for thirties showing an increase with age reaching the highest for sixties followed by a gradual decrease. Since females showed less tuberculosis death rates in the old than males, they showed bi-peaked curve which pertained to a 25-34 year group and sixties. The young age group had been born in 1906-1920 and their adolescence and adult, i. e. tuberculosis susceptible days, were spent during World War II. The old age group composed of those who had been born in 1885-1894 and who had spent their adolescence in the latter part of the Meiji era and their fifties during World War II. It is understood that the present tuberculous death rate curves on age classification indicate the wake of tuberculosis attack suffered by the respective age groups.
  • 大西 磐, 寺西 敦子, 橋本 良子, 田中 美知子, 平 忠臣, 新田 左内
    1959 年 11 巻 3 号 p. 570-574
    発行日: 1959/08/20
    公開日: 2013/02/19
    ジャーナル フリー
  • 牛島 哲, 大北 美子, 池上 達也, 井上 乾三, 篠田 富美子, 半田 博邦
    1959 年 11 巻 3 号 p. 575-579
    発行日: 1959/08/20
    公開日: 2013/02/19
    ジャーナル フリー
  • 友田 平, 笹田 茂三, 福永 ひろ子, 渡辺 としゑ, 中村 倭文子, 松田 冨美
    1959 年 11 巻 3 号 p. 580-581
    発行日: 1959/08/20
    公開日: 2013/02/19
    ジャーナル フリー
  • 橋本 仙一郎, 完岡 市光, 小林 はる枝, 高野 久子
    1959 年 11 巻 3 号 p. 582-587
    発行日: 1959/08/20
    公開日: 2013/02/19
    ジャーナル フリー
    Recently, sulfonamides plus INH has been recommended for pulmonary tuberculosis therapy.
    This study comprised 10 cases of severe pulmonary tuberculosis. Patients were treated daily with 0.3 gm. of INH. and 2 gm. of sulfisomidin for 6 months. The results were as follows:
    1) Body temperature, bo d y weight, blood-sedimentation rate, cough, sputum and appetite were improved at one month, and in no case was there any aggravation of symptoms during the period of chemotherapy.
    2) Tubercle bacilli in the sputum b ecame negative in one patient and was reduced in one patient.
    3) The chest roentgenogram showed improvement in 2 patients with infiltration and in one patient with cavity.
    4) Blood picture:
    a) Anemia improved and hemoglobin reached normal levels at 4 months, the reticulocyte count (below 6 ‰) which had been increased to above 10 ‰ in many patients, and color index (between 0.8 and 1.1.) had not been changed.
    b) In the cases with leucocyte count below 5,000 and neutrophil count below 3,500, the former rose to above 5,000 and the latter to above 3,500 at 3-4 months. In no case did the leucocyte count or the neutrophil count fall. There was a marked shift to the left at the start of treatment, but this had returned to normal at 4 months. The ratio of neutrophils to lymphocytes decreased from 3.0 to 1.0 at about 5 months, and showed relative lymphocytosis.
    c) There was tendency for the th r o m bocyte count to increase.
    5) The abnormalities in the Cobalt R, Cadmium R, and B. S. P. tests showed a tendency to return to normal after 4-5 months.
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