The Author, based on a clinical exprience where a delayed shock ensuing from the massive transfusion of banked blood had been recovered through the transfusion of fresh blood, made an experiment wherein he examined the effect of the transfusion of both banked and fresh blood with respect to the change of circulatory hemodynamics, blood gas composition and acid-base balance to obtain the following conclusion.
1) As regards the circulatory hemodynamics, in consideration of the rate of the recovery of femoral arterial pressure, the fresh blood transfusion shows a better effect. In either case the total peripheral vascular resistance shows a rapid decrease immediately after transfusion, whereas its increase is higher and more rapid in the case of fresh blood transfusion than in the case of banked blood transfusion.
2) The pulmonary arterial pressure has already been begun to rise during the shock, making a more marked rise after both transfusions and falling again later. It is noted however that the comparative rate of increase of the pulmonary arterial pressure vs. the femoral arterial pressure is higher in the case of the banked blood transfusion. The pulmonary vascular resistance shows no perceptible regularity of change after transfusion of banked blood, whereas in the case of fresh blood transfusion it increases rather regularly and then decreases in the like manner.
3) In both cases, the pulmonary blood volume shows more marked increase immediately after transfusion than before bleeding and circulatory blood volume also shows an increase. The relative ratio of increase of the pulmonary blood volume vs. the circulatory blood volume is approximately 1: 3.
4) As regards blood gas composition, in consideration of arterial O₂ content, ₂saturation and A-V ₂ difference, hypoxemia and tissue anoxia is found lasting comparatively longer in the case of banked blood transfusion than in the case of fresh blood transfusion.
5) As regards acid-base balance, the banked blood transfusion maintains metabolic acidosis longer than the fresh blood transfusion and this in higher degrees.
6) In summing up the results in the foregoing, the author concludes that fresh blood transfusion is more effective than banked blood transfusion for the shock recovery, meanwhile, pointing out that rapid transfusion of banked blood in a hemorrhagic shock is one of the factors which cause pulmonary edema. (Author's abstract)

抄録全体を表示

Histological studies are made of the crawfish (Cambarus clarkii) as to the reaction of the epithelial membranous tissue of the shell by antigen injection through the heart or directly through the shell punctured.
An active proliferative reaction in response to antigenic substance (rabbit or goat serum 0.1-0.3cc) administered is showed in the epithelial membranous tissue which probably constitutes a main hematopoietic organ of this animal.
Following intracardial injection of an antigen, some rapid changes occur in the epithelial membrane. The first, occured 6-8 hours of the antigen injection, consists of a diffuse infiltration with basophilic young cells. The reactions show more than one cell type of the tissue including the characteristic globulous cells as it seen lymphnodes of higher animals. The second change following injection consists of proliferation and migration of the basophilic cells of the globules and disappearance of its normal feature. These changes lead to the almost complete loss of the basic appearance of the epithelial membrane.
Arthus' phenomenon is also recognised with the sensitized animals. The reactions of the sensitized animal to the antigen injection appear to be of a fundamentally simillar type to those produced by sensitizing injection of antigen. But the responses are more severe that of described here.
Since the crawfish belongs to the Forssman's guinea pig type, simillar changes also can be see when Forssman's antibody (anti-goat hemolysine) is injected.

抄録全体を表示

Electromyographic studies were made of effects of various drugs injected intravenously on fibrillation voltage appeared in chronically denervated tibialis anterior muscle of rabbit. The drugs used were succinylcholine, nicotine, vagostigmin, acetylcholine, veratrine, hexamethonium, tofranil, adrenaline, dimethylaminoethanol, GABA and quinidine.
1) Succinylcholine, nicotine and veratrine produced remarkable facilitation for several minutes followed by depression of fibrillation voltage continued for fifteen minutes or over.
Vagostigmin and acetylcholine also had the action like succinylcholine, but its potency was much lower than that of the latter drug.
2) Quinidine, adrenaline, tofranil and also GABA produced depression of fibrillation voltage. Before the depression by these drugs was induced, the facilitation of fibrillation voltage was produced for several minutes by quinidine and also by GABA. Dimethylaminoethanol caused the mild, but long continued facilitation after the temporary depression of fibrillation voltage.
3) Hexamethonium had no significant effect on fibrillation voltage.

抄録全体を表示

Ich transplantierte die dorsale (obere) Irishalfte und das linsenglaskorperlose Auge in den Bauch desselben und des anderen Individuums und beobachtete die Befunde bei 79RHACOPHOLUS und 15 TRITURUS PYRRHOGASTER-LARVEN. Die Entwicklungsstadien des RHACOPHOLUS sind No.23-29 nach Y. OKADA, und die des TRITURUS sind No.37-50nach K. OKADA und M. Ichikawa. Ich erreichte die folgenden Ergebnisse aus den Beobachtungen der Befunde.
1. Die dorsale Irishalfte der No.27 Stadiumslarve von RHACOPRHOLUS hat die Linsenpotenz.
2. Nach der Weckung der Linsenpotenz bedurfen die Gebilde das “Etwas” um in die bestimmten Differenzierugsrichtungen zur typischen Linse zu entwickeln. Das “Etwas” muss in der Retina vorhanden sein.
3. Die Regenerationsagens der Weckung von der Linsenpotenz sind die allgemeinen chemischen Stoffe wie das Induktoragens, und diese Stoffe befinden sich in der Dottermasse des Bauches wie in der Retina des Augapfels.
4. Ich glaube, dass der Glaskorper die Regenerationsagens und das “Etwas”, welches die Gebilde, die nach der Weckung von der Linsenpotenz entstehen, in die bestimmten Differenzinrugsrichtung zur typischen Linse entwickelt, beibringt.
5. Die Linse oder Lentoide wird durch die schnelle Entwicklung der Eingeweide in dem Bauch als Fremdkorper gebrochen.
6. Die Implantate werden auch in derselben Weise gebrochen und ins Bindegewebe umwandelt und verlangern die Kiemensack kaudalwarts. Aber nach langen Stunden werden diese allmahlich zum Normalzustand.

抄録全体を表示

In the present experiment, I studied about the changes of serum Na & K concentration during and after administration of Dexamethasone.
No significant changes wsre found between aged pulmonary tuberculous patients and healthy aged or healthy adults. But in the second group, advanced cases were apt to show slight tendency of decreasing in serum Na concentraion.
After administration of Dexamethasone, serum Na concentration slightly increased and serum K concentration showed tendency of decreasing, but their changes were not statistically significant.
Na & K excretion in urine showed close relation to their serum concentration. No side effects were found during and after the administration of Dexamethasone.

抄録全体を表示

The auther investigated premature and still birth in the period 1953-1955. in Ikuno-ku of Osaka City. The results obtaind are as follows:
(1) The rate of premature brith is 2.4% of total live births, and that of premature infants under 2.5 kg birth weight is 85.7%.
(2) As to the rate of premature birth to total births by birth order, that in the cases of the first birth is 4.9%. Especially in the case of mothers 25-34 years of age,6.1%.
(3) The rate of spontaneous still birth is 78 and that of artificial still birth is 38 per 1000 total births.
(4) Spontaneous still birth after 7 months of gestation accounts for half of the total of it. The rate of still birth is 7.8% to live births. In the case of prolific women, however, it is 10%, and 10.6% in the case of mothers 25-34 years of age. In the case of first births for mothers over 35 years of age, it is 12.5%.
(5) Spontaneous still births are 2.6 times more frequent than premature births and 7times in cases involving 5 th births or over.
(6) The rate of premature births, abortions, and still births of mothers having a prematurely born child in past deliveries is higher than that of mothers having full term births.
(7) The morbidity rate of non-obstetric diseased mothers having a premature child is 29% and that of those with obstetric diseases is 27%. The morbidity rate of obstetric diseased mothers having spontaneous still births is 28% and the rate of anomalies of foetus is 21%.

抄録全体を表示

It is already well-known that the main causative agent of allergylike food poisoning is histamine. Proteus morganii and Psudomonas histamineum are notorious for their ability to form histamine from histidine. The author isolated a strain of gram-negative rod from fresh fish meat which utilized lactose and formed histamine from histidine. Studies on allergy-like food poisoning using this strain were carried out and the results are described herein.
1. The histamine producer isolated from cavalias belonged to coli-form group organism. Studies on cultural and physiological characteristics of the strain revealed that the organism resembled to Escherichia intermedia (Bergey's Manual,1957).
2. The strain formed 3.2 to 6.2 mg of histamine per ml in tuna extract. When the strain was inoculated in the fresh meat of cavalias, more than 3.2 mg per gr. of histamine was formed.
3. Histidine decarboxilase activity of the strain was rather stable. After 400 successive subcultures on nutrient agar, the ability of histamine formation of the strain did not decrease.
4. Tuna extract inoculated with this strain caused similar symptoms to human subjects as in the case of so-called allergy-like food poisoning. The results indicated the possibility of food-poisoning caused by this kind of organisms.
5. The distribution of histamine forming strains among naturally occuring Escherichia group organisms was investigated. Eighty nine strains (39.6%) out of 273 isolates formed histamine in cavalias extract. Among these histamine producers, twentyone proved to be an intermediate form by IMVIC system.13 strains (3.5%) also formed histamine in tuna extract, and 4 strains (9.3%) were found to belong to intermediate group. Histidine activity of these strains was weak and unstable, that is, the ability was readily lost on successive subcultures.
Above results show that the histamine producer isolated by the author might be able to cause allergy-like food poisoning in natural condition. High activity of histidine decarboxylase of the strain seems to warrant this strain as a new species among Escherichia coli group organisms, and the strain was tentatively named as E. intermedia n. sp. Yanagisawa et Hirose.

抄録全体を表示

Statistical investigation was made on patients in urological department for 28 years since the establishment of Kansai Medical School.
Total of outpatients 5203(male 4096, female 1107), and in-patients 534 (male 371, female 163).
Lately, the count of patients sharply increase. As the patients with venereal disease, they had increased before with the II Great World War (namely, till 1945), however, of late, they are shown big drop.
Urogenital tuberculosis increased for a few years after War, but decreased remarkably recently.
Urolithiasis showes the increase after War and now the tendency of increase.
Especially, urolithiasis in the upper part is increasing.
Tumor and trauma of urogenital organ show the inclination of increase.

抄録全体を表示

1. A few experiential reports have recently made on each cases of pelvic, primary ureteral and secondary ureterovesical tumors, briefly with some literatures avaible on this subject considerated.
2. Pelvic tumor; Inpatient, who entered hospital complaining of hematuria and lower abdominal pain, result of X-ray finding tried several times was of great value in determining nephroureterectomy with partial cystectomy because X-ray showed nothing on kidney but the filling defect in lower part of the left ureter. It was histologically concluded that milliary nodes were observed in the renal pelvis and microscopic aspect meant capillary carcinoma and the stricture of ureter due to inflammation.
3. Primary ureteral tumor; Inpatient, who complained of symptomless hematuria, left ureteral nephroureterectomy with partial cystectomy was performed under the diagnosis of left tumor in recognition of the peculiar filling defect at the left ureteropelvic junction from an intravenous and retrograde pyelographies. It was determined the primary papillary carcinma of left ureter under the histological examination.
4. Secondary ureterovesical tumor; Inpatient, who had ever undergone right nephrectomy 8 months before under the diagnosis of right renal papillary tumor, thereafter had gradually increase of hematuria, similarly the rest ureterectomy with partial cystectomy was made under the diagnosis of the secondary papillary tumor. It was ureteral papillary carcinoma under the histological examination.
5. From these remarkable characteristics of tumor via upper urinary tract it should be, if possible, taken away with total nephroureterectomy and partial cystectomy.

抄録全体を表示

10 caseses of foreign body in urinary bladder were observed on patients in urological department of Kansai Medical School.
We have made the comparative study on foreign body in the urinary bladder in our clinic and in Japan.

抄録全体を表示

In this manifestation at the result of being operated on the suspicion of appendix testis, in another words, Hydatid of Morgani, the inflammative appendix testis (one is torsion and another is not torsion) was recognized, then the manifestation was cured by resection of both appendix testis.
This is the nineth manifestation in Japan.
Moreover, to the general torsion of appendix testis, the literal consideration was studied.

抄録全体を表示

It is naturally conceivable that the DOPA-oxidase contained in the melanin producing strain may be more active than that of the pyocyanin producing or of the non pigment producing strain of Ps. aeruginosa. The previous experiment hawever showed that the DOPA oxidation by the melanin strain was a little and the culture of th non pigment producing strain seemed to inhibit oxidation as a whole.
In this report, studies are made of the DOPA-oxidase contained in the strains of Ps. aeruginosa.
The 20 strains used are classified 5 types with the activity of these enzymes. The degree of enzymatic action varied in each strain, and even in the supernate of fluid culture or washing bacteria.
Non pigment producing strain of Ps. aeruginosa and Ps. fluorescens are slightly active in DOPA-oxidase.
Cytochrome oxidase and indophenol oxidase are also studied.

抄録全体を表示

Using the larvae of Rhacophohorus schlegelii arborea, Hynobius nebulosus and Triturus pyrrhogaster, the lenses and the vitreus bodies were extracted. This operation was conducted to evaluate the function of the vitreous bodies concerning the lens-regeneration.
1. The radiant fibers of the retinal sustaining cells extended into the ocular chamber toward the margin of the iris, although the sensory cells began to degenerate.
2. When the radiant fibers reached the margin of the iris, they were connected with the epithelial cells of themargin and caused differentiation of the “lentoid” or its piedictive figures.
3. These findings pointed the fact that the radiant fibers determined the differential line of the tegenrated lens, and was agreeable to the theory that the inductive factorcausing the lens-regeneration was common chemicl substances.
4. Degeneration of the retina paralleled degeneration of its sensory cells, but the sustaining cells continued to survive.
5. Regeneration of thelens was independent of degeneration of the operated eye and was depended on the physical condition of the sustaning cells of the retina.

抄録全体を表示