It is generally accepted that the anesthetizing time of rabbits with Barbiturate is prolonged following administration of a certain amount of Cardiazol. In the present experimentation a study was made of the effects of these drugs on the action potential in the central nervous system. The arousal reaction both on the cerebral cortex and hyppocampus which develops following the stimulation of the brain stem reticular formation was no effect by administration of Cardiazol (10mg/kg, i. v. ) after Barbiturate (10mg/kg, i. v. ). Following the above experiment, a pursuance was made of the effects of drugs on recruiting response which appeared following the stimulation of the nucl. centrum medianum and the nucl. ventralis anterior. It was revealed that recruiting response to these nuclei showed a different susceptibility depending upon the agent administered. A series of the experiment of nucl. centrum medianum has demonstrated a trend of increase in recruiting response following administration of Cardiazol. However recruiting response in a case of the nucl. ventralis anterior was depressed following administration of Cardiazol. From above results, it was asserted that what directly concerned the loss of senses was nucl. centrum medianum, not nucl. ventralis anteior, and that nucl. ventralis anterior might play an important role in the development of recruiting response wave, i. e., a consideration of function apart from wave form.
Previously, we have found that chinese ink injected into rabbit pleural cavity or duck skin is detected in the lymphatic capillaries at an early stage and then gathers around and absorbs into the veins of small caliber with time. In order to ascertain whether the same observation is made with human skin, we have investigated the tattoo skin histologically. It was found that the chinese ink gathers preferentially around the veins of small caliber and sweat glands which are especially rich in reticular fibers. Thus it was found that the chinese ink injected into human skin shows the same behavior as the ink injected into duck skin or rabbit pleural cavity.
Though there is little doubt that the first step of the formation of pulmonary hyaline membrane observed in premature infant is primary atelectasis, it is important to get a experimental evidence of this mechanism. Concerning to this respect two experiments were carried, using experimental atelectasis which was caused by artificial pneumothorax in young guinea pigs. The results were followed: 1 Artificial pneumothorax was given unilaterally to young guinea pigs resulting in the development of atelectasis in the treated side which showed a marked formation of the hyaline membrane. 2. When young guinea pigs were given artificial pneumothorax and then put under high oxygen and low humidity environment, they revealed a more marked formation of the hyaline membrane on the treated side.
This is to report two cases of late empyema developed from the residual pleural cavity with calcification after staphylococcal pneumonia. Sixty-two year old male who suffered from exudative pleuritis 35 years ago and 38 year old male with a previuos episode of tuberculous empyema 14 years ago have had the residual pleural cavity with calcification for a long time, and are treated operatively. We feel that the adequate treatment should be done perfectly in the early stage for these cases.