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Volume 20 (1968)
- Issue 4 Pages 273-
- Issue 3 Pages 183-
- Issue 2 Pages 85-
- Issue 1 Pages 1-
Volume 20, Issue 2
Displaying 1-7 of 7 articles from this issue
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Masao Morita, Nobuo Toshioka, Kozo Uda, Masayuki Nomura, Tadashi Iso, ...1968 Volume 20 Issue 2 Pages 85-98
Published: June 20, 1968
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSIncluded are studies of acute toxicity, subacute and chronic toxicity and photosensitizing activities. The results are summarized as follows.
1) A daily dose of trioxsalen of less than 10 mg per kg body weight could be orally given in rats for periods up to six months without apparent toxic effects.
2) In the presence of ultraviolet radiation, trioxsalen and 8-methoxypsoralen evoked changes on the skin of guinea-pig manifested by erythema, and two drugs possessed almost same photosensitizing activities in the case of a local administration in a concentration of 10-3 to 10-2g per ml or in the case of an oral administration in a dose 5 to 10 mg per kg of body weight.View full abstractDownload PDF (2481K) -
III. Anesthetic Effect on Mutual Adhesiveness and Stickiness of Tumor CellsMasatake Sato1968 Volume 20 Issue 2 Pages 99-110
Published: June 20, 1968
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSThe experiment reported here aimed at clarifying the mechanism responsible for the augmenting effect of chloroform or ether.
In the first type of experiment, the effect of these anesthetics on the mutual adhesiveness of Yoshida ascites hepatoma AH 601,7974 was measured by Yamada's method. Results revealed that anesthetics such as chloroform or ether caused the mutual adhesiveness of tumor cells to dissociate, resulting in a liberation of tumor cells from the primary site.
In the second type of experiment, the effect of each anesthetic on the stickiness of tumor cells (AH 13) was measured by Coman's centrifuge method. Analysis of the stickiness of tumor cells during and after each anesthetic revealed no further fluctuation.
To clarify the mechanism responsible for the dissociating effect of ether or chloroform, the negative charge of the surface of Yoshida ascites hepatoma AH601,7974following ether anesthesia was measured by the method of colloid titration.
Experimental results showed that with the time of ether anesthesia prolonged, the negative charge of the cell surface of AH 601 and 7974 tended to increase, resulting in a liberation of tumor cells from the primary site.View full abstractDownload PDF (2657K) -
Michiko Shono1968 Volume 20 Issue 2 Pages 111-135
Published: June 20, 1968
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSA neuropharmacological study was performed concerning the wave type of evoked muscular discharge observed on the fore and hind limbs by an electrical stimulation given to the thalamus, cerebral cortex and hippocampus of rabbits.
As a result of it, it was confirmed that the muscular discharge evoked in this way contains three types, i. e., tonic type, phasic type and tonic phasic type, that tonic type discharges are found oftener on the fore limb than on the hind limb, and that they are noticed oftener in the case of the stimulation of the cerebral cortex than in the case of the stimulation of the thalamus, while not so often in the case of the stimulation of the hippocampus.
From an examination of the regions of stimulation and of the action of drugs, it was assumed that the tonic type discharge in the fore limb is related to the action of the pyramidal system, while the phasic type discharge seen both in the fore and hind limbs is related to the action of the extrapyramidal system.
On the other hand, from the action of various drugs on such evoked muscular discharge and arousal reaction, a study was made about the mechanism of the action of these drugs on the central nervous system, too, and at the same time, an examination was done about the problems of the flexor and extensor and the muscular discharge of abnormal excitation caused by drugs.View full abstractDownload PDF (5654K) -
Haruko Oae1968 Volume 20 Issue 2 Pages 136-154
Published: June 20, 1968
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSFor the purpose of elucidating the central nervous mechanism related with neural and muscular symptoms of uremia, the electroencephalography (the arousal reaction and recruiting response) and electromyography were studied for rabbits injected by urea and for rabbits of which ureters were ligated. In the latter cases, the implantation of electrodes was employed.
The following conclusions were obtained:
1) The structure related to the extrapyramidal system exerted inhibitory effects on the diffuse projection system.
2) The administration of a small dose of urea inhibited the sensory system with no effect on the motor system and a gradual increase in the dose began to give a facillitatory effect on the motor system. Both systems, however, were inhibited by an administration of a large amount of urea. This supports the suggestion that the midbrain reticular formation has not only a function of sensory system but also a function of the motor system.
3) The excitation of the motor system in the thalamus exerted a facillitatory effect on the motor system of the reticular formation.
4) The moderating system in the reticular formation was excited by the administration of a small dose of urea and consequently exerted a facillitatory effects on the diffuse projection system.
5) Histologically, degeneration of nervous cells was observed both in the cerebral cortex and the midbrain reticular formation.
6) It is expected that in the early stage of uremia, the neural and muscular symptoms appear by the action of urea.View full abstractDownload PDF (4119K) -
Michiko OGAWA, Masumi GOTO, Hiroshi OKUBO, Hirofumi OKAMURA, Reiko TAK ...1968 Volume 20 Issue 2 Pages 155-172
Published: June 20, 1968
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSClinical cases of Japanese encephalitis were observed, especially as to the relationship between the clinical features and the autopsy findings in four cases.
1) The clinical features coincided well with the autopsy findings
.2) Arteriosclerosis in aged patients seemed to aggravate the circulatory disturbances caused by the encephalitis in its acute and subacute stages, resulting in irreversible brain damages. In such cases, secondary intracerebral hemorrhage or wide-spread encephalomalacia is often fatal.
3) As for the proper changes concerning blood vessels in the eacute encephalitic stage, congestion and petechiae were histologically observed; in severe cases, subarachnoideal hemorrhage and hematuria were not rare in their acme stage. These findings suggest that as much attention should be paid to the blood vessel disorders as to the secondary infections.
4) On the basis of the above findings, the authors could successfully treat one aged patient with hemostatics, especially large dosages of carbazochrome, combined with ACTH, adrenal corticoids, γ-globulin, a brain pressure depressant, and a brain metabolism stimulant.
5) As a supplement, the authors here report on a case of acute encephalitis, the symptoms of which are quite similar to those of Japanese encephalitis, but, as revealed by serological examinations, is caused by the ECHO-4 virus.View full abstractDownload PDF (4894K) -
1968 Volume 20 Issue 2 Pages 173-176
Published: June 20, 1968
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSDownload PDF (757K) -
1968 Volume 20 Issue 2 Pages 177-181
Published: June 20, 1968
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSDownload PDF (1060K)
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