関西医科大学雑誌

人胎児肝の電子顕微鏡的研究

1 .肝細胞ならびに内皮細胞

笹内忠

1971 年 23 巻 1 号 p. 1-31
発行日: 1971/03/20
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.23.1_1

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The livers of human embryos 8-32 weeks of age were studied electron microscopically. The liver cells showed marked differences in ultrastructure in various phases of development. The free polysomes decresed in number and the endoplasmic reticulum appear to undergo structural reorganization from vesicotubular to lamellar type around the third month. 'Simultaneously the smooth endoplasmic reticulum and hemosiderin granules appeared, and the glycogen granules increased markedly. These sturctural changes probably correspond to the start of the embryonic hematopoiesis and the biosynthesis of serum proteins in the liver.

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第23巻第3号正誤表

1971 年 23 巻 1 号 p. e1-
発行日: 1971年
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.23.1_e1

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Vol. 23 (1971) No. 3 p. 355-459

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人胎児肝の電子顕微鏡的研究

II.造血細胞

笹内忠

1971 年 23 巻 1 号 p. 32-50
発行日: 1971/03/20
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.23.1_32

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The ultrastructural changes of the erythropoietic cells in the fetal liver were studied electron microscopically, and these changas were tried to correlate with the cytochemicrl studies on erythrocytic development.
Incorporation into the eythropoietic cells of ferritin particles by rhopheocytosis (micropinocytosis)was observed in detail. The ultrastructure of the thrombopoietic cells was also clescribed. Inturelationships of the parenchymal -cells with mesenchymal hematopoietic cells were studied and discussed.

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家蚕血球細胞に関する研究I

光学顕微鏡的研究

横田隆寿

1971 年 23 巻 1 号 p. 51-66
発行日: 1971/03/20
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.23.1_51

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Blood cells of the silkworm, Bombyx mori, were samplied sucessively from the beginning of the third instar to the pupal stadium, and were oberved by a light microscope. The blood cells were classified to five kinds; proleucocytes, plasmatocytes, granular cells, spherule cells and oenocytoides, and their structural properties were described. Further, it was suggested that the granular cells are derived from the proleucocytes. The cell count ( or the number of cells in 1 mma ) of the silkworm showed a cyclic change; minimum or decreasing in the beginning of each instar, then increase rapidly, arriving at a maximum number during molting period (or, in the fifth instar, two days after the ripening). The granular cells and proleucocytes were the main components of the blood cells. In the early stage of each instar, the plasma cells were numerous, which, however, decreased gradually and in the molting stadium compensatory increase of the granular cells was observed.

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家蚕血球細胞に関する研究II

電子顕微鏡的研究

横田隆寿

1971 年 23 巻 1 号 p. 67-92
発行日: 1971/03/20
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.23.1_67

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Ultrastructure of five kinds of blood cells of the silkworm, Bombyx mori, has been studied. Proleucocytes are primitive cells, rich in free polyrihosomes and containing a few rough endoplasmic reticulum. It is suggested that granular cells and spherule cells are differentiated from the proleucocytes. Ultrastructure of the plasmatocytes is quite similar to that of the proleucocytes. Granular cells contain well developed rough endoplasmic reticulum with dilated cisternal cavity, as well as a number of specific granules that are probably formed by the Golgi apparatus. The granular cells are active in phagocytosis and in secretion. Spherule cells usually contain several large spherical granules which are probably to be secreted out of the cells. Oenocytoides have a number of cytoplasmic free polyribosomes and inclusion bodies. There are two kinds of inclusion bodies; one is fibrous material composed of fine filaments and the other is round or oval bodies with homogeneous content. It is suggested that these inclusion bodies are proteineous materials synthesized by the free polyribosomes.

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フタロジニトリルの神経毒作用に関する実験的研究

第1篇フタロジニトリルによるけいれん発作とその向神経作用に関する電気生理学的検討

伊藤純一

1971 年 23 巻 1 号 p. 93-101
発行日: 1971/03/20
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.23.1_93

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フタロジニトリルの神経毒作用に関する実験的研究

第2篇植え込み電極法によるフタロジニトリルくりかえし投与の影響に関する検討

伊藤純一

1971 年 23 巻 1 号 p. 102-106
発行日: 1971/03/20
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.23.1_102

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フタロジニトリルの神経毒作用に関する実験的研究

第3篇フタロジニトリルによるけいれん発作におよぼす各種抗てんかん剤の影響

伊藤純一

1971 年 23 巻 1 号 p. 106-111
発行日: 1971/03/20
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.23.1_106

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フタロジニトリルの神経毒作用に関する実験的研究

第4篇フタロジニトルの毒性に関する病理組織学的検討

伊藤純一

1971 年 23 巻 1 号 p. 112-114
発行日: 1971/03/20
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.23.1_112

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フタロジニトリル神経毒作用に関する実験的研究

第5篇総括並に考按

伊藤純一

1971 年 23 巻 1 号 p. 115-126
発行日: 1971/03/20
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.23.1_115

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The toxic action of phthalodinitrile (abbr, P D N) on the nervous system was investigated by the electrophysiological method in rabbits.
1. The neuro-physiological investigation of the cramp attack caused by P D N and its neurotoxic action.
2. The effect of the repeated administration of P D N by the inplanted electrode method.
3. The effect of anti-convulsants on the cramp attack caused by P D N.
4. The patho-histological investigation of the toxic action of P D N.
5. The summary and consideration of the experimental investigations.
The results obtained are as follows:
1) Clonic cramp attacks of the whole body were always observed when over 25mg/kg of P D N was administered intraperitoneally and also sometimes when 10-20 mg/kg of P D N was administered.
The repeated administration of, a small dose caused cramp attack, and a single administration of the dose did not cause it.
2) An administration of P D N acted inhibitorily on the arousal reaction in the E E G caused by the electro-stimulus in the thalamus and midbrain reticulum formation an d acted acceleratively on the simultaneously evoked muscle discharges.
3) The seizures were evoked in the E E G of neo-and archi-cortex after the administration of P D N to the rabbits of cerveau isole, however the cramp attacks of the whole body were not observed.
Anti-convulsants, that is, Acetazolamide, Dichlorphenamide, etc, depressed the seizure waves in the E E G caused by P D N.
It may be said that the hyper-kinetic effec t of P D N acts on the higher part of the brain.
4) In the cases of the acute experiments, the slow waves in the neo-cortex E E G preceded to the seizure waves; the ropeated administration of P D N 10mg/kg caused the slow-wave in the neo-cortex E E G.
It may be said that the slow waves caused by the administration of P D N are the premonitor of cramp attack.5) Pseudocerebral phagocytes, slight infiltration and atrophy of the cerebral cells were observed in the cases of the repeated administration of P D N for 60 days, but t here is no evidence of edema and inflammation.

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家蚕後部絹糸腺リボゾーム、およびポリゾームの沈降解析

山口登, 大槻英一, 田代裕

1971 年 23 巻 1 号 p. 127-131
発行日: 1971/03/20
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.23.1_127

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家蚕Bombyx Mori(平安x郡白)の5令の後部絹糸腺を材料として,ショ糖密度勾配法と沈降速度法によるボリゾームの分祈を行なった.摘出した後部絹糸腺に氷冷中のRat liver supematantを加えてホモゲナイズし,遠心分離後その上清をDOC処理してボリゾーム分析の試料とした.
この試料を,0.5-1.0M,ショ糖密度勾配の上に重層し,日立40P型分離用超遠心機にて分析した結果,5令の24時間目から48時闇目にポリゾームのピークをもつとも明確に検出出来た.
ショ糖密度勾配法にて後部絹糸腺のリボゾームのモノゾームを採取し,これをSPINCO E型分祈用超遠心機にて沈降速度法分析を行なった.その結果からモノゾームの沈降係数は,79.6Sであると算出出来た.

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Strophanthin-Gの心房毒性発現の要因とTrimetazidineの拮抗効果に関する実験的研究

小谷雅子

1971 年 23 巻 1 号 p. 132-139
発行日: 1971/03/20
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.23.1_132

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On the strophanthin-G toxicity and influences of trimetazidine on it, changes of inorganic ions content in isolated guinea-pig atria were examined.
1) The strophanthin-G toxicity was marke dly reduced in a low sodium medium and it was increased in a low potassium medium.
2) A potassium-free medium or a toxic dose of strophanthin-G caused a decrease in potassium content and an increase in sodium content in atria.
3) Trimetazidine prevented a decrease in potassium c ontent but could scarcely prevent an increase in sodium content in atria kept in a normal Locke's solution containing strophanthin-G in a toxic dose.
4) Trimetazidine may reduce strophanthin-G toxicity perhaps through inhibiting the efflux of atrial potassium.

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QuinidineおよびThiamine tetrahydrofurfuryl disulfideの家兎心電図におよぼす影響

小谷雅子

1971 年 23 巻 1 号 p. 140-147
発行日: 1971/03/20
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.23.1_140

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Quinidine and thiamine tetrahydrofurfuryldisulfide (TTFD) were investigated for their effects on ECG of rabbit in relation to interaction of these drugs. The QRS complex, P-Q interval and Q-T interval were prolonged after the intravenous injection of 17.5mg/kg of quinidine. TTFD injected intravenously in doses of 10 to 20 mg/kg prolonged R-R interval for 2 to 3 hours and depressed sinus node activity for 1 to 5 minutes. Premedication of TTFD in above doses reduced changes of QRS complex and P-Q interval caused by quinidine.

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大脳辺縁系の視覚誘発電位におよぼす影響

窪田惺

1971 年 23 巻 1 号 p. 148-164
発行日: 1971/03/20
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.23.1_148

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It has been well known that the limbic system plays an important role in behavioral and emotional disorders. In relation to this concept, the effects of limbic stimulation upon photic evoked potentials were investigated.
Sixty-five rabbits were imm obilized by succinylcholine chloride, and respiration was artificially maintained. Electrodes were stereotaxically implanted in septum, hippocampus, amygdala, lateral geniculate body, superior colliculus and visual cortex. Twenty repeated evoked responses were averaged by average transient computer (ATAC).
Photic potentials evoked in bilateral visual cortex and later al geniculate body were accentuated or suppressed by preceding stimulation of septum. Preceding stimulation of hippocampus also facilitated or inhibited photic evoked potentials in bilateral visual cortex and lateral geniculate body. Amygdala had facilitatory effects on photic evoked potentials in bilateral visual cortex and lateral geniculate body. However, these interactions disappeared in association with intravenous barbiturate injection and in cerveau isole rabbits. These results clarify behavioral disorders concomitant with limbic irritation and also certify that the mesencephalic reticular formation takes an important part of these interactions.

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メチルチオウラシルによる重症穎粒球減少症で回復期に類白血病反応を伴なった一例

粉川皓年, 岡本緩子

1971 年 23 巻 1 号 p. 165-171
発行日: 1971/03/20
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.23.1_165

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A case of severe agranulocytosis with leukemoid reaction induced by methylthiouracil was reported. The patient was a 26 years old nurse suffering from hyperthyroidism. She was admitted to our clinic with complaints of high fever and sore throat. From her history and laboratory findings, this: case was diagnosed as agranulocytosis induced by Methyl-thiouracil. The patient was successfully treated with ACTH, steroid hormone and fresh-blood-transfusion from a chronic myeloic leukemia patient. Leukemoid reaction was recognized in her convalescent stage.

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胃粘膜下膵嚢胞の一例

山口登, 綱川和夫, 岩間卓治, 青崎義親, 中井勇, 宍戸晃一

1971 年 23 巻 1 号 p. 172-176
発行日: 1971/03/20
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.23.1_172

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A submucosal pancreatic cyst in the stomach wall, grown in the posterior wall of the central part of the antrum, was observed in a 22 years old male.
X-ray examination of the stomach demonstrated a semicircula r shadow defect in the antrum. Corresponding to that, a tumor was found endoscopically, which was considered to a submucosal one, although neither typical bridging folds nor central depression were shown. Beside, two ulcers were found at the gastric angle.
Resected stomach disclosed that the tumor, mea suring 40 X 37 X 15mm, was a submucosal cyst, which was later diagnosed histologically as an aberrant pancreatic tissue dilated like a cyst.

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